DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and Arntl2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_038963872.1	Gene:	Arntl2 / 362464	RGDID:	620230	Length:	625	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	183/553 - (33%)
Similarity:	270/553 - (48%)	Gaps:	74/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTYK 79
            ||.|.:.|:|||:||...|.:||.|:|.....|.|.|||:|||.||.::::.||..........|
  Rat    88 REAHSQTEKRRRDKMNHLIWKLSSMIPPHIPTAHKLDKLSILRRAVQYLRSQRGMTEFYLGENAK 152

  Fly    80 PSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREK 144
            |||:.|:||.||||:||:|||.||.|:.||:::||.||:..|:|.|:...|.:|::.:.|.|..|
  Rat   153 PSFIQDKELSHLILKAAEGFLLVVGCEGGRILFVSKSVSKTLHYDQASLMGQNLFDFLQPKDVAK 217

  Fly   145 IREQLSTQES--------QNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESM 201
            ::||||...|        ::...:..|.|..|....|....|:..|:||.|..||:.....|.
  Rat   218 VKEQLSCDVSLREKPIGTKSEFFLQSLASPQVHSHSHIGRSRVHSGSRRSFFFRMKSSCTVPV-- 280

  Fly   202 VSGHLNRLKQR-NSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGR 265
                  :.:|| :|....:|...:..:|||||:::|||..:.....|... .|.....||||:||
  Rat   281 ------KEEQRCSSCSKKKDQRKFHTIHCTGYLRSWPPNVVGTEKEMGSG-KDSGPLTCLVAMGR 338

  Fly   266 LQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHM 330
            ||..:....:...:...:|||||.||:|||.:||||...||||.|.||||..||::||.:|.|::
  Rat   339 LQPYTVPPKNGKINVRPAEFITRFAMNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNL 403

  Fly   331 KESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLD 395
            .:....||:.|.::.:..|:.|.|:..:|.|:::.::|.||:|.::||||..|:         |.
  Rat   404 SDKHKAVLQSKEKILTDSYKFRVKDGSFVTLKSKWFSFTNPWTKKLEYIVSVNT---------LV 459

  Fly   396 AAAAHTPEQVQQ--QQQQEQHVYVQ---AAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQ 455
            ...:.|...|.|  ..|..:..:.|   :.||:  :...|...||...|  ....:|::
  Rat   460 LGRSETAVSVPQCRSSQSSEDSFRQPCVSVPGI--STGTLLGAGSIGTD--IANEVLSL------ 514

  Fly   456 QQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQ 520
             |:.....|..|  .|.|...| .||             ...|::|.||:.....||.|:
  Rat   515 -QRSHSSSPEDA--NPSGVVRD-KHS-------------VNFGSAPVPVSTGELFALSPE----- 557

  Fly   521 QQPVTEGY----QYQQTSPA--RSPSGPTYTQL 547
                |||.    |:|...||  ..|.....|||
  Rat   558 ----TEGLEAARQHQSAEPAHCHKPLLSDSTQL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	24/51 (47%)
		PAS	87..192	CDD:279347	43/112 (38%)
		PAS	90..154	CDD:214512	30/63 (48%)
		PAS_11	283..384	CDD:291273	45/100 (45%)
		PAS	283..380	CDD:238075	43/96 (45%)
Arntl2	XP_038963872.1	bHLH_SF	87..146	CDD:412148	26/57 (46%)
		PAS	171..268	CDD:238075	33/96 (34%)
		PAS_11	357..464	CDD:405306	47/115 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850