DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and arntl1b

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_005166673.1	Gene:	arntl1b / 352935	ZFINID:	ZDB-GENE-030408-1	Length:	676	Species:	Danio rerio

Alignment Length:	547	Identity:	205/547 - (37%)
Similarity:	307/547 - (56%)	Gaps:	68/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNT 72
            |::...:||.|.:||:|||:||.::|.||:.:||||:|::||.||||:|||||.|||.|||..|.
Zfish   123 DQQMKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGAANP 187

  Fly    73 SSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHI 137
            .::..|||:||:|.|||||||:|||||||||.||.|::::||:||..:|||:|:|..|.||::::
Zfish   188 YTEANYKPAFLSDDELKHLILKAADGFLFVVGCDRGKILFVSESVYKILNYSQNDLIGQSLFDYL 252

  Fly   138 HPDDREKIREQLSTQESQNAGRILDLKSG-TVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESM 201
            ||.|..|::||||:.::....|::|.|:| .|:.:...|..||..||||.|.|||:..    .||
Zfish   253 HPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVRTDIAPSPSRLCSGARRSFFCRMKCN----RSM 313

  Fly   202 VSGHLNRLKQRNSLGPS------RDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHC-- 258
            |       |..:...||      .|..::..:|.|||:|:||||    .|.::.|.:..:..|
Zfish   314 V-------KMEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPT----KMGLDEDNEPDNEGCNL 367

  Fly   259 -CLVAIGRLQ---VTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICY 319
             ||||||||.   |......|:  ....:|:::|||:||||.|||||...||.|.|.||||...|
Zfish   368 SCLVAIGRLHPHIVPQPVNGDI--RVKPTEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSFY 430

  Fly   320 DFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNS 384
            ::||.:|..|:.|...|||:.:.::.:..|:.:.|:..::.||::.::|:||:|.||||||.||:
Zfish   431 EYFHQDDIGHLAECHRQVLQMREKINTHCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNT 495

  Fly   385 SGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQA------APGVDYARRE-LTPVGSATNDGMY 442
               .:.|:.:|.|....| |:....|....|...|      .||:....|. ...:|....:.:.
Zfish   496 ---VVSGSSVDGAEPGFP-QLSASPQSMDSVLTAADGSGKTVPGLPGGTRAGAGKIGRMIAEEVM 556

  Fly   443 QTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPN 507
            :.|.:            :...|.|..::|:..: ::|..|.::   ||.|:  |.....||..|:
Zfish   557 EIHRI------------RGSSPSSCGSSPLNIS-NSTPPPDTS---SPAAR--KMSNGGTPDIPS 603

  Fly   508 SWAALRPQQQQQQQQPVTEGYQYQQTS 534
              |.|...|.       :.||.|..:|
Zfish   604 --AGLGSGQD-------SIGYPYSNSS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	32/51 (63%)
		PAS	87..192	CDD:279347	54/105 (51%)
		PAS	90..154	CDD:214512	36/63 (57%)
		PAS_11	283..384	CDD:291273	45/100 (45%)
		PAS	283..380	CDD:238075	42/96 (44%)
arntl1b	XP_005166673.1	HLH	130..182	CDD:278439	32/51 (63%)
		PAS	202..309	CDD:279347	55/106 (52%)
		PAS	205..264	CDD:214512	33/58 (57%)
		PAS_11	395..498	CDD:291273	46/105 (44%)
		PAS	397..492	CDD:238075	42/94 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850