DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and npas2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_840084.1	Gene:	npas2 / 352934	ZFINID:	ZDB-GENE-030408-3	Length:	845	Species:	Danio rerio

Alignment Length:	700	Identity:	176/700 - (25%)
Similarity:	281/700 - (40%)	Gaps:	143/700 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSAL-----ARKPDKLTILRMAV 60
            |||   .:|:| |.|.:..:.|::||::....|.||      |:.|     .||.||.|||:..:
Zfish    34 MDE---DEKDR-AKRASRNKSEKKRRDQFNVLIKEL------CTMLQGQGHPRKMDKSTILQRTI 88

  Fly    61 AHM-KALRGTGNTSS---DGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVL 121
            ..: |....|..|.|   ...:|||||:::|...|:|||.||||..::.| |.:|||||||:.::
Zfish    89 DFLQKQKEITAQTESCEVRQDWKPSFLSNEEFTQLMLEALDGFLIALTTD-GNIIYVSDSVSSLI 152

  Fly   122 NYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRG 186
            .:..||....::...:...:...:.:.||:.........:||.:   ..|.|..
Zfish   153 GHLPSDMVDQNILNFLPEREHADVYKLLSSHMLLTESSTVDLLN---SNETHVE----------- 203

  Fly   187 FICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDV 251
            |.|.:..||::|:...:....:.     :|..:...|..:..|.||...:|.|       ::..:
Zfish   204 FCCHIARGNIDPKEPPTYEYVKF-----VGDFKFHNNVPLSSCNGYDLAFPRT-------LQSSI 256

  Fly   252 DDMSSHCCLVAIGRLQVTSTAANDMSGSNNQ-SEFITRHAMDGKFTFVDQRVLNILGYTPTELLG 315
            ::   ..||||..|| .|.....|:....:. .||.:||:::.||.|:|.|...|:||.|.|:||
Zfish   257 EE---QVCLVATVRL-ATPQFLKDLCNVEDVCDEFTSRHSLEWKFLFLDHRASPIIGYLPFEVLG 317

  Fly   316 KICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIV 380
            ...||::|.:|...:.:...| |.|.|:..|..||...|..:::||:|..|...:.:..:.|:||
Zfish   318 TSGYDYYHVDDLELIAQCHKQ-LMQCGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIV 381

  Fly   381 CTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQE-----------------QHVYVQAAPGVDYARR 428
            ||:|              ..:..:|:.::::|                 |.|::...|.::..|.
Zfish   382 CTHS--------------VVSYAEVRAERRREFGLEESSSDMATSSIKGQEVFLDMCPPLEATRD 432

  Fly   429 ELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAG-GPSPLA 492
            .:....|.::....::...|:.              .||..:.|.||...|.|..||. ||...:
Zfish   433 RINSARSVSSQSSRKSSHTALS--------------DSASNSSVRYTEACTSSRQSASIGPEKSS 483

  Fly   493 -KIPKSGT----------SPTPVAPN-SWAALRPQQQQQQQQP---VTEGYQYQQTSPARSPSGP 542
             ::..:||          .|..::|: |..:...|.....|||   |....:.|.....|.....
Zfish   484 NRMTHTGTKTLIQRQSSSEPPSLSPSCSQHSAMTQSLYSFQQPQLGVMHQLKEQLEERTRILQAD 548

  Fly   543 TYTQ----------LSAGNGNRQQAQP--GAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHPH 595
            ..||          |...|......||  |.: ||..|....||.  ..|...||.|.|..:|..
Zfish   549 IKTQQQELHDIKEKLQLANLQMLLQQPIQGEF-AGSGPQQQGPGR--PAQQNTHPKPQHCVSHSS 610

  Fly   596 HPHAHPGGPAGAGQPQ----GQEFSDMLQMLDHTPTTFEDLNINMFSTPF 641
            |. ..|...:..||.:    |...:..:.|..||..|          |||
Zfish   611 HT-LQPNSSSTQGQQRLVQAGHMQAVSVPMQTHTSLT----------TPF 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	17/57 (30%)
		PAS	87..192	CDD:279347	28/104 (27%)
		PAS	90..154	CDD:214512	21/63 (33%)
		PAS_11	283..384	CDD:291273	37/100 (37%)
		PAS	283..380	CDD:238075	33/96 (34%)
npas2	NP_840084.1	HLH	40..96	CDD:238036	19/62 (31%)
		PAS	119..>203	CDD:307226	26/87 (30%)
		PAS_3	285..388	CDD:330807	38/117 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577637
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740