DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tgo and Ncoa1

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_017449617.1	Gene:	Ncoa1 / 313929	RGDID:	1309046	Length:	1443	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	136/618 - (22%)
Similarity:	219/618 - (35%)	Gaps:	159/618 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANIQDKERFASRENHCE-----IERRRRNKMTAYITELSDM----VPTCSALARKPDKLTILR 57
            |.||....:|   :.:.|:     .|:|||.:...|:.||:::    :....:|:.||||..||:
  Rat    10 DPANPDSHKR---KGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILK 71

  Fly    58 MAVAH---MKALRGTGNTSSDGTYKPSF-------LTDQELKHLILEAADGFLFVVSCDSGRVIY 112
            ..|..   ||.:....:|:.|...|...       :..:.|..|:|||.|||.|||:|: ||:::
  Rat    72 KTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIVF 135

  Fly   113 VSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSM 177
            ||::||..|.|.|.:...||:|..:|..|..:..:.|..:...|.   :.......::..|.
  Rat   136 VSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG---VPWPQEATRRNSHT--- 194

  Fly   178 RLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGT-------NYAVVHCTGYIKN 235
                     |.|||.   ::|                  |...||       .|.|:.|  :..:
  Rat   195 ---------FNCRML---IHP------------------PDEPGTENQEACQRYEVMQC--FTVS 227

  Fly   236 WPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQ 300
            .|.:       ::.|.:|..|  ||:.|.|......|...:      ..|:|:....||...:|.
  Rat   228 QPKS-------IQEDGEDFQS--CLICIARRLPRPPAITGV------ESFMTKQDTTGKIISIDT 277

  Fly   301 RVLNILGYTPTE-LLGKICYDFFHPE--DQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLR 362
            ..|...|.|..| |:.|..|.||.|:  :.|:.::.|.:|:.          |..|.:..|.::
  Rat   278 SSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMT----------RGTASSPSYRFI- 331

  Fly   363 TQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYAR 427
                  ||..|                      ..:|||..::...|..:...::.....:|...
  Rat   332 ------LNDGT----------------------MLSAHTKCKLCYPQSPDMQPFIMGIHIIDREH 368

  Fly   428 RELTP------------VGSATNDGMYQTHMLAMQAPTPQQQQQQ-QQRPGSAQTTPVGYTYDTT 479
            ..|:|            :..:.|.|:...|.:...:..|...... ..|....|:|.:......:
  Rat   369 SGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHS 433

  Fly   480 HSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTY 544
            :|..|.|         ..|.||......|.|..:.|...|...|        ..:...||...|.
  Rat   434 NSSSSQG---------SFGCSPGNQIVASVALSQGQAGSQSSNP--------SLNLNNSPMEGTG 481

  Fly   545 TQLSAGNGNRQQAQPG----AYQAGPPPPPNAP 573
            ..|:.....|:||..|    |..:....|||.|
  Rat   482 ISLAQFMSPRRQANSGLATRARMSNNSFPPNIP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	18/63 (29%)
		PAS	87..192	CDD:279347	32/104 (31%)
		PAS	90..154	CDD:214512	26/63 (41%)
		PAS_11	283..384	CDD:291273	24/103 (23%)
		PAS	283..380	CDD:238075	24/99 (24%)
Ncoa1	XP_017449617.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	17/59 (29%)
		PAS	120..213	CDD:238075	32/129 (25%)
		PAS_11	260..370	CDD:405306	29/148 (20%)
		NCOA_u2	469..591	CDD:406952	13/46 (28%)
		SRC-1	633..709	CDD:400955
		DUF4927	744..821	CDD:406644
		Nuc_rec_co-act	927..972	CDD:400942
		Med15	995..>1362	CDD:312941
		DUF1518	1152..1208	CDD:400033
		DUF1518	1215..1270	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910