Protein Alignment tgo and sim1a

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_835740.2
• Gene: sim1a / 260351
• ZFINID: ZDB-GENE-020829-1
• Length: 745
• Species: Danio rerio
• Alignment Length: 677
• Identity: 160/677 - (23%)
• Similarity: 257/677 - (37%)
• Gaps: 171/677 - (25%)

  Fly    15 RENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL----RGTG----- 70
            :|......|.||.|..:...||:.::|..||:..:.||.:|:|:..:::|..    .|.|
Zfish     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESWGH 66

  Fly    71 ---NTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTS 132
               .||.:.       ..:||...:|:..|||:|||:.| |:::|:|::.:..|..:|.:..|.|
Zfish    67 VSRTTSLEN-------VGRELGSHLLQTLDGFIFVVAPD-GKILYISETASVHLGLSQVELTGNS 123

  Fly   133 LYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVN 197
            :||:|||.|.:::...|:..:..::..:            |:..|      .|.|..||:.
Zfish   124 IYEYIHPADHDEMTAVLTAHQPYHSHFV------------HEYEM------ERSFFLRMKC---- 166

  Fly   198 PESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIK-NWPPTDMFPNMHMERDVDDMSSHCCLV 261
                      .|.:||: |.:..|  |.|:||:||:| .....||.|       .|....:..||
Zfish   167 ----------VLAKRNA-GLTCGG--YKVIHCSGYLKIRQYSLDMSP-------FDGCYQNVGLV 211

  Fly   262 AIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPED 326
            |:|. .:..:|..::...:|.  |:.|.::|.|..|:|.||..:.||.|.:|:.|..|...|..|
Zfish   212 AVGH-SLPPSAVTEIKLHSNM--FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCD 273

  Fly   327 QSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTD------EVEYIVCTNSS 385
            ..|:: ....:|..|||:.:..||..||...:||:::.|....|..:.      .|.|:: |::.
Zfish   274 TFHLR-CAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVL-TDTE 336

  Fly   386 GKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQ 450
            .|.:. ..||.||:..|          ...|...:..|...||    ||.:.          ..:
Zfish   337 YKGLQ-LSLDQAASTKP----------SFTYNSPSNPVTENRR----VGKSR----------VSR 376

  Fly   451 APTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQ 515
            ..|..:.....|.||    .|...:.....||:   |.|||.    ...||
Zfish   377 TKTKTRLSPYSQYPG----FPTDRSESDQDSPW---GGSPLT----DSASP-------------- 416

  Fly   516 QQQQQQQPVTEGYQYQQTSPARS------------PSGPTYTQLSAGNGNRQQAQPGAYQAGPPP 568
            |..:|.:.:.....|:|.|..||            .|...|:...:.:..|...:.|.|..|.|
Zfish   417 QLLEQCEGIESSCVYRQFSDPRSLCYGLPLTEDHHTSNELYSHPHSESCERGCCKAGRYFLGTP- 480

  Fly   569 PPNAPGMWDWQQAGGHPHPPHPTAHPHH--------PH-------------------AHPGGPAG 606
               .||...|..| .....|.|.:.|.:        ||                   :.|.|  |
Zfish   481 ---QPGREAWWGA-ARSVLPLPKSSPENGDSFEGVMPHIASIHSLQVRGHWDEDSAVSSPDG--G 539

  Fly   607 AGQPQGQEF-SDMLQMLDHTPTTFEDL 632
            :....|..| :|..:.....|:..|.|
Zfish   540 SASDSGDRFRADQCRSSPQEPSKIETL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	18/70 (26%)
		PAS	90..154	CDD:214512	22/63 (35%)
		PAS_11	282..384	CDD:464214	32/107 (30%)
sim1a	NP_835740.2	bHLH-PAS_SIM1	1..71	CDD:381581	17/68 (25%)
		PAS	88..>158	CDD:238075	23/88 (26%)
		PAS_3	243..329	CDD:430001	25/86 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..413		18/97 (19%)
		SIM_C	358..647	CDD:461963	50/255 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		4/32 (13%)