DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tgo and Arnt

DIOPT Version :10

Sequence 1:NP_731308.1 Gene:tgo / 41084 FlyBaseID:FBgn0264075 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_036912.3 Gene:Arnt / 25242 RGDID:2153 Length:809 Species:Rattus norvegicus


Alignment Length:754 Identity:334/754 - (44%)
Similarity:426/754 - (56%) Gaps:139/754 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL 66
            ||.:..||||.| ||||.|||||||||||||||||||||||||||||||||||||||||:|||:|
  Rat    79 DEQSSADKERLA-RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL 142

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            |||||||:||:||||||||||||||||||||||||:|||::|||:|||||||||||..||:|:|:
  Rat   143 RGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGS 207

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVG-- 194
            :||:.:||||.:|:||||||.|:...|||||||:|||||||.|||||:.||:||.||||||.|  
  Rat   208 TLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGTS 272

  Fly   195 NVNPESMVSGHLNRL-----KQRNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVD 252
            :|:|.||     |||     :.||.||..::| .::.|||||||||.|||..: .|:       |
  Rat   273 SVDPVSM-----NRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPD-------D 325

  Fly   253 D----MSSHCCLVAIGRLQVTSTA-ANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTE 312
            |    ..|..||||||||||||:. ..|||.....:|||:||.::|.|||||.|.:..:||.|.|
  Rat   326 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQE 390

  Fly   313 LLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVE 377
            ||||...:|.|||||..:::||.||:|.|||:.|:::|.||||.|::|:||.::.|.|||:||:|
  Rat   391 LLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRAKNREWLWMRTSSFTFQNPYSDEIE 455

  Fly   378 YIVCTNSSGKTMHGAPLDAAA-----------------------------------AHTPEQVQQ 407
            ||:|||::.|.....|....:                                   ....:|.||
  Rat   456 YIICTNTNVKNSSQEPRPTLSNTIQRSQLGPTTNLSLEMGTGQLASRQQQQQQQQQQQQQQQQQQ 520

  Fly   408 QQQQEQHVYVQAAPGVD----YARRELT--PV---GSATNDGMYQTHMLAMQAPTPQQQQ----- 458
            ||||:|...:...||.|    |:..:::  ||   ||..:..:.::..|.:|...|:..:     
  Rat   521 QQQQQQQTELDMVPGRDGLASYSHSQVSVQPVATAGSEHSKPLEKSEGLFVQDRDPRFSEIYPNI 585

  Fly   459 -QQQQRPGSAQTTPVGYTYDTTHSPYSAG-----GPSPLAKIPKSGTSP--TPVAPNSWAALRPQ 515
             ..|.:..|:.|.|      .|...:|.|     .|.|......||.:|  |.|.|:| :|.:..
  Rat   586 SADQSKGLSSSTVP------ATQQLFSQGSSFPPNPRPAENFRNSGLTPPVTIVQPSS-SAGQIL 643

  Fly   516 QQQQQQQPVTEGYQYQQTSPARSP-SGPTYTQLSA-------GNGNRQQAQ-------PGAYQAG 565
            .|..:...:|:|.....||..|.. |....||.:|       |..|.|.:.       |||..|.
  Rat   644 AQISRHSNLTQGSAPTWTSSTRPGFSAQLPTQATAKTRSSQFGVNNFQTSSSFSAMSLPGAPTAS 708

  Fly   566 P-----PPPPN--------------------APGMWDWQQAGGHPHPPHPTAHPHHPHAHPGGPA 605
            |     |..||                    |.|:..|.|..|  ..||..:..:..|..|....
  Rat   709 PSTAAYPTLPNRGSNFPPETGQTTGQFQTRTAEGVGVWPQWQG--QQPHHRSSSNEQHVQPTSAQ 771

  Fly   606 GAGQPQGQEFSDMLQMLDHTPTTF---EDLNINMFSTPF 641
            .:.||  :.|.:||.||.....|:   |..::.|| .||
  Rat   772 PSSQP--EVFQEMLSMLGDQSNTYNNEEFPDLTMF-PPF 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tgoNP_731308.1 bHLH-PAS_ARNT 9..74 CDD:381517 59/64 (92%)
PAS 90..154 CDD:214512 46/63 (73%)
PAS_11 282..384 CDD:464214 55/101 (54%)
ArntNP_036912.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..95 10/16 (63%)
bHLH-PAS_ARNT 86..150 CDD:381517 59/64 (92%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762 88..128 37/40 (93%)
Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762 112..264 120/151 (79%)
Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762 112..168 51/55 (93%)
PAS 163..269 CDD:395786 78/105 (74%)
Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762 167..171 3/3 (100%)
PAS_11 362..462 CDD:464214 55/99 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..487 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..575 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..685 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..735 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..809 19/65 (29%)
Blue background indicates that the domain is not in the aligned region.

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