DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and Npas2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_032745.2	Gene:	Npas2 / 18143	MGIID:	109232	Length:	816	Species:	Mus musculus

Alignment Length:	811	Identity:	185/811 - (22%)
Similarity:	281/811 - (34%)	Gaps:	249/811 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVA---- 61
            |||   .:|:| |.|.:..:.|::||::....|.|||.|:|   ...||.||.|:|...:.
Mouse     1 MDE---DEKDR-AKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQK 58

  Fly    62 HMKALRGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQS 126
            |.:....|........:|||||:::|...|:|||.|||:.||:.| |.:||||||:||:|.:..:
Mouse    59 HNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTD-GSIIYVSDSITPLLGHLPA 122

  Fly   127 DWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRM 191
            |....:|...:...:..::.:.||:..         |.:.:...|..:|...|.      |.|.:
Mouse   123 DVMDQNLLNFLPEQEHSEVYKILSSHM---------LVTDSPSPEFLKSDNDLE------FYCHL 172

  Fly   192 RVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSS 256
            ..|::||:...:....:.     :|..|...|.....|.|:..........|   :.:||
Mouse   173 LRGSLNPKEFPTYEYIKF-----VGNFRSYNNVPSPSCNGFDNTLSRPCHVP---LGKDV----- 224

  Fly   257 HCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDF 321
              |.:|..||.................||.:||:::.||.|:|.|...|:||.|.|:||...||:
Mouse   225 --CFIATVRLATPQFLKEMCVADEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDY 287

  Fly   322 FHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNS-- 384
            :|.:|...:... .|.|.|.|:..|..||...|..:::||:|..|...:.:..:.|:||||:|
Mouse   288 YHIDDLELLARC-HQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVV 351

  Fly   385 ----------SGKTMHGAPLDAAAAHTPEQVQQQQQ-----QEQHVYVQAAPGVDYARRELTPVG 434
                      ....:...|.:  |.| |..|:::..     |..:.....|.|:     ..:|..
Mouse   352 SYADVRVERRQELALEDPPTE--AMH-PSAVKEKDSSLEPPQPFNALDMGASGL-----PSSPSP 408

  Fly   435 SATNDGMYQTHMLAMQAPT---------------PQQQQQQQQRP----GSAQTTPVGYTYDTTH 480
            ||::...:::...||..||               |:.....|:.|    ..|.|.|.     ..|
Mouse   409 SASSRSSHKSSHTAMSEPTSTPTKLMAENSTTALPRPATLPQELPVQGLSQAATMPT-----ALH 468

  Fly   481 SPYSAGGPSP--LAKIPKSG--TSPTPVAPNS-------------------------W------- 509
            |..|......  |..:|::|  :.|.||...|                         |
Mouse   469 SSASCDLTKQLLLQSLPQTGLQSPPAPVTQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHK 533

  Fly   510 ---------------------------AALRPQQQQQ-QQQP---------VTEGYQYQQTS--- 534
                                       :..||..||| ||:|         |....|.|.||
Mouse   534 IQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPAAQQQLQQRPAAPSQPQLVVNTPLQGQITSTQV 598

  Fly   535 ------------PARSPSGPTYTQLSAGNGNRQQAQPGAY------------------------Q 563
                        .|:.|.....:||...:|....:.|..:                        |
Mouse   599 TNQHLLRESNVISAQGPKPMRSSQLLPASGRSLSSLPSQFSSTASVLPPGLSLTTIAPTPQDDSQ 663

  Fly   564 AGPPP----------------PPNAPGMWDWQQ-------------AGGHPHPPHPTAHPHHPHA 599
            ..|.|                .|..||..|.:|             |......|.|.:||.:..|
Mouse   664 CQPSPDFGHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQVMFPSPDSHPTNSSA 728

  Fly   600 ------------HPGGPAGAGQP----QGQE 614
                        ||..||....|    |.|:
Mouse   729 STPVLLMGQAVLHPSFPASRPSPLQPAQAQQ 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	17/55 (31%)
		PAS	87..192	CDD:279347	31/104 (30%)
		PAS	90..154	CDD:214512	24/63 (38%)
		PAS_11	283..384	CDD:291273	37/100 (37%)
		PAS	283..380	CDD:238075	33/96 (34%)
Npas2	NP_032745.2	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	24/82 (29%)
		Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269\|PubMed:23831463	1..61		23/66 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		8/23 (35%)
		PAS	84..195	CDD:366402	35/131 (27%)
		PAS_11	249..352	CDD:373151	38/103 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..431		15/74 (20%)
		omega_3_PfaA	<440..>740	CDD:274311	50/304 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..639		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..705		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..816		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740