DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and Ncoa2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_017174718.1	Gene:	Ncoa2 / 17978	MGIID:	1276533	Length:	1517	Species:	Mus musculus

Alignment Length:	755	Identity:	170/755 - (22%)
Similarity:	265/755 - (35%)	Gaps:	222/755 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NIQDKERFASRE-NHC----------EIERRRRNKMTAYITELSDMVPTCSALAR---------K 49
            |..|..|..:|: ..|          ..|:|.|.:...||.||::::     .|.         |
Mouse     7 NTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELI-----FANFNDIDNFNFK 66

  Fly    50 PDKLTILRMAVAHMKALR-------------GTGNTSSDGTYKPSFLTDQELKHLILEAADGFLF 101
            |||..||:..|..::.::             ...:.||.|   ...:....|..::|||.|||.|
Mouse    67 PDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTG---QGVIDKDALGPMMLEALDGFFF 128

  Fly   102 VVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSG 166
            ||:.: |.|::||::||..|.|.|.:....|:|..:|..|..:..:.|..:...|.|.    .||
Mouse   129 VVNLE-GSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGS----WSG 188

  Fly   167 TVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTG 231
            ...:....:           |.|||.|..: |:|...||.::...:          .|..:.|
Mouse   189 EPPRRSSHT-----------FNCRMLVKPL-PDSEEEGHDSQEAHQ----------KYEAMQC-- 229

  Fly   232 YIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFT 296
            :..:.|.:       ::.:.:|:.|  ||:.:.| :|.......:..|.:   |.||..:.||.|
Mouse   230 FAVSQPKS-------IKEEGEDLQS--CLICVAR-RVPMKERPTLPSSES---FTTRQDLQGKIT 281

  Fly   297 FVDQRVLNILGYTPTELLGKICYDFFHP----EDQSHMKESFDQVLKQKGQMFSLLYRARAKNSE 357
            .:|...:........|.|.:.|...||.    |..|:.|....:||:| |..||.:||....:..
Mouse   282 SLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQ-GLAFSQIYRFSLSDGT 345

  Fly   358 YVWLRTQAYAFLNPYTDEVEYI-----------VCT---NSSGKTMHGAPLDAAAAHTPEQVQQQ 408
            .|..:|::....:..|:|.:.:           ||.   :.:|:.| |.||:..::.:|
Mouse   346 LVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAM-GKPLNPISSSSP------ 403

  Fly   409 QQQEQHVYVQAAPGVDYA------------RREL-TPVGSATNDGMYQTHMLAMQAPTPQ----- 455
               .........||.|..            :.:: .|:|.....| ...|:..|||.|||
Mouse   404 ---AHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSG-GMNHVSGMQATTPQGSNYA 464

  Fly   456 ------QQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSP-----TPV----- 504
                  .|......||.|.:.   .:.....||..||.|    :||.|..||     :||
Mouse   465 LKMNSPSQSSPGMNPGQASSV---LSPRQRMSPGVAGSP----RIPPSQFSPAGSLHSPVGVCSS 522

  Fly   505 -------APNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAY 562
                   ..:|..||         |.::||:.....|...||      .|..||          .
Mouse   523 TGNSHSYTNSSLNAL---------QALSEGHGVSLGSSLASP------DLKMGN----------L 562

  Fly   563 QAGP----PPPPNAPGMWDWQQAGG-HPHPPHPTAHPHHPHAHP---GGPAGAGQPQ-------- 611
            |..|    |||.:..|..|.:...| :..|...|........||   .||..:..||
Mouse   563 QNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAE 627

  Fly   612 ---------GQEFSDMLQML---------DHTPTTFEDLN 633
                     ||  :.:||:|         ...|::..|.|
Mouse   628 GHSRLHDSKGQ--TKLLQLLTTKSDQMEPSPLPSSLSDTN 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	17/71 (24%)
		PAS	87..192	CDD:279347	31/104 (30%)
		PAS	90..154	CDD:214512	23/63 (37%)
		PAS_11	283..384	CDD:291273	29/118 (25%)
		PAS	283..380	CDD:238075	27/111 (24%)
Ncoa2	XP_017174718.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	15/67 (22%)
		PAS	118..175	CDD:214512	22/57 (39%)
		PAS_11	268..378	CDD:405306	27/113 (24%)
		NCOA_u2	463..587	CDD:406952	35/155 (23%)
		SRC-1	636..709	CDD:400955	8/32 (25%)
		DUF4927	731..816	CDD:406644
		Nuc_rec_co-act	1076..1120	CDD:400942
		Med15	<1130..>1408	CDD:312941
		DUF1518	1284..1341	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810