DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and Arnt

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001032826.1	Gene:	Arnt / 11863	MGIID:	88071	Length:	791	Species:	Mus musculus

Alignment Length:	755	Identity:	332/755 - (43%)
Similarity:	423/755 - (56%)	Gaps:	159/755 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL 66
            ||.:..||||.| ||||.|||||||||||||||||||||||||||||||||||||||||:|||:|
Mouse    79 DEQSSADKERLA-RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL 142

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            |||||||:||:||||||||||||||||||||||||:|||::|||:|||||||||||..||:|:|:
Mouse   143 RGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGS 207

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVG-- 194
            :||:.:||||.:|:||||||.|:...||:||||:|||||||.|||||:.||:||.||||||.|
Mouse   208 TLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGTS 272

  Fly   195 NVNPESMVSGHLNRL-----KQRNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVD 252
            :|:|.||     |||     :.||.||..::| .::.|||||||||.|||..: .|:       |
Mouse   273 SVDPVSM-----NRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPD-------D 325

  Fly   253 D----MSSHCCLVAIGRLQVTSTA-ANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTE 312
            |    ..|..||||||||||||:. ..|||.....:|||:||.::|.|||||.|.:..:||.|.|
Mouse   326 DPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQE 390

  Fly   313 LLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVE 377
            ||||...:|.|||||..:::||.||:|.|||:.|:::|.|:|..|::|:||.::.|.|||:||:|
Mouse   391 LLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIE 455

  Fly   378 YIVCTNSSGKTMHGAPLDAAAAHTPE----------------QVQQQQQQEQHVYVQAAPGVD-- 424
            ||:|||::.|.....|....:...|.                |:..:|||:||..:...||.|
Mouse   456 YIICTNTNVKNSSQEPRPTLSNTIPRSQLGPTANLSLEMGTGQLPSRQQQQQHTELDMVPGRDGL 520

  Fly   425 ----YARRELTPVGSA---------TNDGMY-------------------QTHMLAMQAPTPQQQ 457
                :::..:.||.||         .::|::                   ...:.:...|..||.
Mouse   521 ASYNHSQVSVQPVASAGSEHSKPLEKSEGLFAQDRDPRFPEIYPSITADQSKGISSSTVPATQQL 585

  Fly   458 QQQ------QQRP-----GSAQTTPVGYTYDTTHSPYSAGGPSPLAKI-----PKSGTSPTPVAP 506
            ..|      ..||     .|..|.||     |...|.|:.| ..||:|     |..|::||
Mouse   586 FSQGSSFPPNPRPAENFRNSGLTPPV-----TIVQPSSSAG-QILAQISRHSNPAQGSAPT---- 640

  Fly   507 NSW-AALRP----QQQQQQQQPVTEGYQYQ----QTSPARS----PSGPTYTQLSAGNGNRQQAQ 558
              | ::.||    ||...|....|...|:.    |||.:.|    |..||     |.:|.
Mouse   641 --WTSSSRPGFAAQQVPTQATAKTRSSQFGVNNFQTSSSFSAMSLPGAPT-----ASSGT----- 693

  Fly   559 PGAYQAGPPPPPNAP------------------GMW-DWQQAGGHPHPPHPTAHPHHPHAHPGGP 604
             .||.|.|....|.|                  |:| .||  |..||....::..|........|
Mouse   694 -AAYPALPNRGSNFPPETGQTTGQFQARTAEGVGVWPQWQ--GQQPHHRSSSSEQHVQQTQAQAP 755

  Fly   605 AGAGQPQGQEFSDMLQMLDHTPTTF---EDLNINMFSTPF 641
            :     |.:.|.:||.||.....|:   |..::.|| .||
Mouse   756 S-----QPEVFQEMLSMLGDQSNTYNNEEFPDLTMF-PPF 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	48/51 (94%)
		PAS	87..192	CDD:279347	76/104 (73%)
		PAS	90..154	CDD:214512	46/63 (73%)
		PAS_11	283..384	CDD:291273	53/100 (53%)
		PAS	283..380	CDD:238075	50/96 (52%)
Arnt	NP_001032826.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..97		11/18 (61%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:26245371, ECO:0000269\|PubMed:28602820	88..128		37/40 (93%)
		HLH	91..143	CDD:278439	48/51 (94%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000269\|PubMed:26245371	112..264		119/151 (79%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000269\|PubMed:26245371	112..168		51/55 (93%)
		PAS	163..269	CDD:279347	77/105 (73%)
		PAS	166..230	CDD:214512	46/63 (73%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000269\|PubMed:24001774	167..171		3/3 (100%)
		PAS_11	362..462	CDD:291273	53/99 (54%)
		PAS	362..458	CDD:238075	50/95 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..508		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..554		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..667		11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..715		11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..791		19/68 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834636
Domainoid	1	1.000	165	1.000	Domainoid score	I3902
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1330
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm42502
orthoMCL	1	0.900	-	-		OOG6_105223
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2390
SonicParanoid	1	1.000	-	-		X1928
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780