DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and NCOA2

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_016868450.1	Gene:	NCOA2 / 10499	HGNCID:	7669	Length:	1533	Species:	Homo sapiens

Alignment Length:	742	Identity:	171/742 - (23%)
Similarity:	262/742 - (35%)	Gaps:	213/742 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NIQDKERFASRE-NHC----------EIERRRRNKMTAYITELSDMVPTCSALAR---------K 49
            |..|..|..:|: ..|          ..|:|.|.:...||.||::::     .|.         |
Human     7 NTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELI-----FANFNDIDNFNFK 66

  Fly    50 PDKLTILRMAVAHMKALR-------------GTGNTSSDGTYKPSFLTDQELKHLILEAADGFLF 101
            |||..||:..|..::.::             ...:.||.|   ...:....|..::|||.|||.|
Human    67 PDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTG---QGVIDKDALGPMMLEALDGFFF 128

  Fly   102 VVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSG 166
            ||:.: |.|::||::||..|.|.|.:....|:|..:|..|..:..:.|..:...|.|.    .||
Human   129 VVNLE-GNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGS----WSG 188

  Fly   167 TVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTG 231
            ...:....:           |.|||.|..: |:|...||.|:...:          .|..:.|
Human   189 EPPRRNSHT-----------FNCRMLVKPL-PDSEEEGHDNQEAHQ----------KYETMQC-- 229

  Fly   232 YIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFT 296
            :..:.|.:       ::.:.:|:.|  ||:.:.| :|.......:..|.:   |.||..:.||.|
Human   230 FAVSQPKS-------IKEEGEDLQS--CLICVAR-RVPMKERPVLPSSES---FTTRQDLQGKIT 281

  Fly   297 FVDQRVLNILGYTPTELLGKICYDFFHP----EDQSHMKESFDQVLKQKGQMFSLLYRARAKNSE 357
            .:|...:........|.|.:.|...||.    |..|:.|....:||:| |..||.:||....:..
Human   282 SLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQ-GLAFSQIYRFSLSDGT 345

  Fly   358 YVWLRTQAYAFLNPYTDEVEYI-----------VCT---NSSGKTMHGAPLDAAAAHTPEQVQQQ 408
            .|..:|::....:..|:|.:.:           ||.   :.:|:|| |.||:..::::|
Human   346 LVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTM-GKPLNPISSNSP------ 403

  Fly   409 QQQEQHVYVQAAPGVDYA------------RREL-TPVGSATNDGMYQTHMLAMQAPTPQ----- 455
               .........||.|..            :.:: .|:|.....| ...|:..|||.|||
Human   404 ---AHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSG-GMNHVSGMQATTPQGSNYA 464

  Fly   456 --QQQQQQQRPGSAQTTPVGYTYDTTH--SPYSAGGPSPLAKIPKSGTSP-----TPV------- 504
              .....|..||.....|.. .....|  ||..||.|    :||.|..||     :||
Human   465 LKMNSPSQSSPGMNPGQPTS-MLSPRHRMSPGVAGSP----RIPPSQFSPAGSLHSPVGVCSSTG 524

  Fly   505 -----APNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQA 564
                 ..:|..||         |.::||:.....|...||      .|..||          .|.
Human   525 NSHSYTNSSLNAL---------QALSEGHGVSLGSSLASP------DLKMGN----------LQN 564

  Fly   565 GP----PPPPNAPGMWDWQQAGG-HPHPPHPTAHPHHPHAHPGGPAGAGQP-------------- 610
            .|    |||.:..|..|.:...| :..|...|........|||.......|
Human   565 SPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQ 629

  Fly   611 ------QGQEFSDMLQMLDHTPTTFED 631
                  :||  :.:||:|    ||..|
Human   630 SRLHDSKGQ--TKLLQLL----TTKSD 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	17/71 (24%)
		PAS	87..192	CDD:279347	31/104 (30%)
		PAS	90..154	CDD:214512	23/63 (37%)
		PAS_11	283..384	CDD:291273	29/118 (25%)
		PAS	283..380	CDD:238075	27/111 (24%)
NCOA2	XP_016868450.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810