Protein Alignment tgo and sim1

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: XP_004914602.1
• Gene: sim1 / 100486719
• XenbaseID: XB-GENE-485816
• Length: 763
• Species: Xenopus tropicalis
• Alignment Length: 666
• Identity: 157/666 - (23%)
• Similarity: 266/666 - (39%)
• Gaps: 149/666 - (22%)

  Fly    15 RENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL----RGTGNTSSD 75
            :|......|.||.|..:...||:.::|..||:..:.||.:|:|:..:::|..    .|.|.....
 Frog     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGH 66

  Fly    76 GTYKPSFLTD--QELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIH 138
             |.:||.|.:  :||...:|:..|||:|||:.| |:::|:|::.:..|..:|.:..|.|:||:||
 Frog    67 -TSRPSTLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIYEYIH 129

  Fly   139 PDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVS 203
            |.|.:::...|:..:..::..:.:.:                  ..|.|..||:.
 Frog   130 PADHDEMTAVLTAHQPYHSHFVQEYE------------------IERSFFLRMKC---------- 166

  Fly   204 GHLNRLKQRNSLGPSRDGTNYAVVHCTGYIK-NWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQ 267
                .|.:||: |.:..|  |.|:||:||:| .....||.|       .|....:..|||:|. .
 Frog   167 ----VLAKRNA-GLTCGG--YKVIHCSGYLKIRQYSLDMSP-------FDGCYQNVGLVAVGH-S 216

  Fly   268 VTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKE 332
            :..:|..::...:|.  |:.|.::|.|..|:|.||..:.||.|.:|:.|..|...|..|..|::
 Frog   217 LPPSAVTEIKLHSNM--FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLR- 278

  Fly   333 SFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTD------EVEYIVCTNSSGKTMHG 391
            ....:|..|||:.:..||..||:..:||:::.|....|..:.      .|.|:: |::..|.:.
 Frog   279 CAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVL-TDTEYKGLQ- 341

  Fly   392 APLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQ 456
            ..||......|           ..|..:.|.::.:|:       ::...:..|...:..:|.||.
 Frog   342 LSLDQVTTKPP-----------FSYTSSNPTINDSRK-------SSKARLSNTKSKSRTSPYPQY 388

  Fly   457 QQQQQQRPGSAQTTPVGYTYDTTHSPY-SAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQ 520
            .               |:..:.:.|.: |..|.|||.    ...||..:.|..    ||...|..
 Frog   389 S---------------GFHTERSESDHESQWGGSPLT----DTASPQLLDPIE----RPSSHQHD 430

  Fly   521 QQPVTEGY-QYQQTSPARSPSGPTYTQLSAGNGNRQQA------QPGAYQAGPPP---------- 568
               |:..| ||...|.........:::||....:..|:      :.|.|..|.|.
 Frog   431 ---VSCAYRQYPDRSGLCFGFSIDHSRLSDDRHHHSQSCEGGRCEAGRYFLGSPQTGRETWWGSR 492

  Fly   569 -----PPNAPGMWDWQQAGGHPHPPH-PTAHPHHPHAH-----------PGGPAGAGQPQGQEFS 616
                 |..:|...|..:|    ..|| .:.|..|..:|           ||..:.:|.   :..:
 Frog   493 SVLPVPKTSPDGKDIYEA----TMPHIASGHRAHGRSHWEEDSVVSSPDPGSASESGD---RYRT 550

  Fly   617 DMLQMLDHTPTTFEDL 632
            |..|...|.|:..|.|
 Frog   551 DQYQNSHHEPSKIETL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	17/62 (27%)
		PAS	90..154	CDD:214512	22/63 (35%)
		PAS_11	282..384	CDD:464214	32/107 (30%)
sim1	XP_004914602.1	bHLH-PAS_SIM1	1..71	CDD:381581	18/69 (26%)
		PAS	88..>158	CDD:238075	21/88 (24%)
		PAS_3	243..329	CDD:430001	25/86 (29%)
		SIM_C	357..668	CDD:461963	49/250 (20%)