DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tgo and arnt

DIOPT Version :9

Sequence 1:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	XP_012825275.1	Gene:	arnt / 100144695	XenbaseID:	XB-GENE-855450	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	332/735 - (45%)
Similarity:	421/735 - (57%)	Gaps:	128/735 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKAL 66
            ||.:..||||.| ||||.|||||||||||||||||||||||||||||||||||||||||:|||:|
Frog    72 DEQSSADKERLA-RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSL 135

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            ||||||.:|||||||||||||||||||||||||||||||::||::|||||||||||..||:|:|:
Frog   136 RGTGNTPTDGTYKPSFLTDQELKHLILEAADGFLFVVSCETGRIVYVSDSVTPVLNQPQSEWFGS 200

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGN- 195
            :||:.:||||.:|:||||||.|:...|||||||:|||||||.|||||:.||:||.||||||.||
Frog   201 TLYDQVHPDDLDKLREQLSTAENAMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNA 265

  Fly   196 -VNPESMVSGHLNRLKQRNSLGPSRDG-TNYAVVHCTGYIKNWPPTDM-FPNMHMERDVD-DMSS 256
             :.|.||......|.:.||.||||:|| ..:.|||||||||.|||..: .|    |.|.| ..||
Frog   266 VIEPSSMNRLSFMRNRCRNGLGPSKDGEPQFVVVHCTGYIKAWPPAGVTLP----EDDPDAGQSS 326

  Fly   257 HCCLVAIGRLQVTST-AANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYD 320
            ..||||||||||||: ...|::......|||:||.:||.|||||.|....:||.|.|||||...:
Frog   327 KFCLVAIGRLQVTSSPTCTDINTVCQPIEFISRHGVDGLFTFVDHRCTATVGYQPQELLGKDIVE 391

  Fly   321 FFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSS 385
            |.|||||..:::||.||:|.|||:.|:::|.|:|..|::.:||.::.|.|||:||:|||:|||::
Frog   392 FAHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLLMRTSSFTFQNPYSDEIEYIICTNTN 456

  Fly   386 GKTMH--------------------GAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGV---DYAR 427
            .|..:                    ..|:|......|.:.||.|...|...|.:..|:   ::.:
Frog   457 VKNSNQEPRPALASTIQRPPLGPSINHPMDMGQTQLPGRQQQPQAPPQTDVVPSREGLGSYNHTQ 521

  Fly   428 RELTPVGSATND---------GMY------------------QTHMLAMQAPTPQQQQQQQQRPG 465
            ..:.||.:|.:|         |||                  |:..|.....:..||..||....
Frog   522 VPVQPVSAAVSDHSKPLEKTEGMYGQERDPRFAEIYSNINSDQSKSLNPSGVSGNQQLFQQSSTF 586

  Fly   466 SAQTTPVGYTYDTTHSPYSAGG--PSP------------LAKIPKSGTSPTPVAPNSWAA-LRPQ 515
            ::...||        ..:.:||  |.|            ||:|.:. ||||.|...:|:: .||.
Frog   587 TSAPRPV--------ESFRSGGMVPQPSIIQQPVSAGQILAQISRH-TSPTQVTGTNWSSGTRPS 642

  Fly   516 ---QQQQQQQPVTEGYQY----------------QQTSPARSPSGPTYTQLSAGNGN--RQQAQP 559
               ||...|.|.|:..|:                .|:|.| ||:|..|..::....|  .:.|||
Frog   643 FTAQQVPTQTPKTQASQFGMGNFQATPSSFSPLSSQSSTA-SPAGAPYPSMTGRTSNFATEVAQP 706

  Fly   560 -GAYQAGPPPPPNAPGMW-DWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQML 622
             |.:||   ...:|.|:| .||.    .|....||..|         ......|.:.|.|||.||
Frog   707 RGQFQA---RAADAVGVWPQWQS----QHHGQSTAESH---------VSQQSNQTEVFPDMLSML 755

  Fly   623 DHTPTTF---EDLNINMFST 639
            ....:::   |...:|||.:
Frog   756 GDQTSSYSNEEFSELNMFQS 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_001262397.1	HLH	15..67	CDD:278439	48/51 (94%)
		PAS	87..192	CDD:279347	77/104 (74%)
		PAS	90..154	CDD:214512	46/63 (73%)
		PAS_11	283..384	CDD:291273	53/100 (53%)
		PAS	283..380	CDD:238075	50/96 (52%)
arnt	XP_012825275.1	bHLH-PAS_ARNT	79..143	CDD:381517	59/64 (92%)
		PAS	156..262	CDD:366402	78/105 (74%)
		PAS_11	355..455	CDD:373151	53/99 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm47601
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2390
SonicParanoid	1	1.000	-	-		X1928
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100