DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and rnf115a

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_001073542.1	Gene:	rnf115a / 790928	ZFINID:	ZDB-GENE-061215-82	Length:	310	Species:	Danio rerio

Alignment Length:	384	Identity:	112/384 - (29%)
Similarity:	159/384 - (41%)	Gaps:	122/384 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAMVVEDRPAEAKRFFCHMCNVEINIPNSDFTCPLCANGFVEELPANAPEMDSSTAG------ 59
            ||||..|...     |||||.|..|::....::.||.|.:||:||:..::..:|:|:.|
Zfish     1 MAEAAAVPPH-----RFFCHCCKGEVSPKLPEYICPRCDSGFIEEVTEDSSLLDNSSNGLDDTSS 60

  Fly    60 --------------------ASGSARSGSSGSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLL 104
                                :..|.|....||||.|.      |:...|.
Zfish    61 QFAELWQLLFVERPFGLDLDSLDSERLPGGGSGSGGF------GAGPFGG--------------- 104

  Fly   105 NMRNVPNLEITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAG----------------GRVRPAN 153
               :||                  ||.|||.|...:.|...|                |..||..
Zfish   105 ---SVP------------------GGLGGPLGGPLSGGEHWGPGRPPRLHTQRRYRSRGSSRPDR 148

  Fly   154 LDRLDNVLFDFLQSLPLAGATAEIVTG-PGGGGVGGGGNSHMFFMGNPGDYAWGREGLDTIVTQM 217
            ...::.::..|     |||..|.  :| ||...|......|    .||||||||:.|||.::||:
Zfish   149 SPAVEGIVQQF-----LAGLFAN--SGVPGSPPVSWTSMLH----SNPGDYAWGQGGLDAVITQL 202

  Fly   218 LNQMETSGPPPLSAQRINEIPNVQINAEEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVP 282
            |.|.|.:||||...::|:.:|.|.|..|..:..::|.:|.:|:.:.|.||:|||:|.:|.:||||
Zfish   203 LGQFENTGPPPAEKEKISSLPTVIITQEHTDCNMECPVCKEDYTVGEPVRQLPCNHFFHSDCIVP 267

  Fly   283 WLNLHSTCPICRKSLADDGNDADDEFVMLDAFGPEMAADGSNSERRSASTATGTDNPSP 341
            ||.||.|||:|||||                     ..|.|.::..|..::..||..:|
Zfish   268 WLELHDTCPVCRKSL---------------------NGDESGTQSSSEPSSLNTDPRTP 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030	13/29 (45%)
		RING-H2_RNF126_like	252..294	CDD:319581	22/41 (54%)
		HRD1	<253..372	CDD:227568	33/89 (37%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	22/39 (56%)
rnf115a	NP_001073542.1	zinc_ribbon_9	11..41	CDD:291067	13/29 (45%)
rnf115a	NP_001073542.1	zf-RING_2	237..279	CDD:290367	22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9275
eggNOG	1	0.900	-	-		E33208_3BCP6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	1	1.000	-	-		FOG0000184
OrthoInspector	1	1.000	-	-		otm24792
orthoMCL	1	0.900	-	-		OOG6_102823
Panther	1	1.100	-	-	LDO	PTHR15710
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1936
SonicParanoid	1	1.000	-	-		X390
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.950