DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and Rnf215

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_082135.2	Gene:	Rnf215 / 71673	MGIID:	1918923	Length:	379	Species:	Mus musculus

Alignment Length:	205	Identity:	48/205 - (23%)
Similarity:	76/205 - (37%)	Gaps:	61/205 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ANLDRLDNVLFDFLQSLPLAGATAEIVTGP----------------GGGGVGGGGNSHMFFMG-- 198
            :|:.:|...|....|      |||||.:|.                |....|.||...:..:|
Mouse   187 SNVTKLLEALLQRTQ------ATAEISSGESLSANIEWKLTLWTTCGLSKDGYGGWQDLVCLGGA 245

  Fly   199 -----NPGDYAWGREGLDTIVTQML----------------NQMETSGPPPLSAQR-INEIPNVQ 241
                 .|....|..    .::..||                ||.|..|...|..:| :..:.:::
Mouse   246 QAQEQKPLQQLWNA----ILLVAMLLCTGLVVQAQRQASRQNQQEPGGQEDLFKRRVVRRLASLK 306

  Fly   242 INAEEVNRKIQ---------CSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSL 297
            .....::|...         |::|.|.|...:.:|.|||.|.:|.:|:.|||.|..|||:|:.::
Mouse   307 TRRCRLSRAAHSLPEPGTETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNV 371

  Fly   298 ADDGNDADDE 307
            .  ||...|:
Mouse   372 L--GNHYSDD 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030
		RING-H2_RNF126_like	252..294	CDD:319581	18/50 (36%)
		HRD1	<253..372	CDD:227568	22/55 (40%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	18/39 (46%)
Rnf215	NP_082135.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..63
		zf-RING_2	325..368	CDD:290367	18/42 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910