DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and rnf115b

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	XP_003200594.1	Gene:	rnf115b / 563879	ZFINID:	ZDB-GENE-060503-608	Length:	301	Species:	Danio rerio

Alignment Length:	320	Identity:	102/320 - (31%)
Similarity:	152/320 - (47%)	Gaps:	64/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAMVVEDRPAEAKRFFCHMCNVEINIPNSDFTCPLCANGFVEELPANAPEMDSSTAGASGSAR 65
            ||||..     |...|||||.|..||:....::.||.|.:||:||:..|...:.:         |
Zfish     1 MAEAAA-----APRHRFFCHCCKGEIDPKLPEYVCPRCESGFIEEVSENFSLLQN---------R 51

  Fly    66 SGSSGSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMRNVPNLEITIEPNRRHSNVLHLGG 130
            .|::|:||                    :.:.:....|..:..:.:..:..||:  .::.|...|
Zfish    52 DGAAGTGS--------------------DDMTSQFAELWQLLFMEHSALLSEPS--VTDALRSSG 94

  Fly   131 FGGPSGSDSARGLTAG--------------GRVRPANLDRLDNVLFDFLQSLPLAGATAEIVTGP 181
            . .|:.:|.|.| |||              .:..|....|.|       |...:.|...:.:.|.
Zfish    95 L-QPAVADPASG-TAGPVASVESLSDCTEPQQNSPQTNSRQD-------QGQAVEGIVQQFLAGL 150

  Fly   182 GGGGVGGGGNSHMF---FMGNPGDYAWGREGLDTIVTQMLNQMETSGPPPLSAQRINEIPNVQIN 243
            .......|..:..:   ...||||||||:.|||.:|||:|.|.|.|||||...:.|:.:|.|.|:
Zfish   151 FSNSDSAGPQTSSWSSALHSNPGDYAWGQGGLDAVVTQLLGQSENSGPPPAEKEMISSLPTVSIS 215

  Fly   244 AEEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGND 303
            :|:...:::|.:|.::|.:.|:||:|||.|.:|.:||||||.||.|||:|||||  ||.|
Zfish   216 SEQAACRLECPVCREEFSVGESVRQLPCLHYFHSSCIVPWLQLHDTCPVCRKSL--DGED 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030	14/29 (48%)
		RING-H2_RNF126_like	252..294	CDD:319581	22/41 (54%)
		HRD1	<253..372	CDD:227568	30/51 (59%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	22/39 (56%)
rnf115b	XP_003200594.1	zinc_ribbon_9	11..41	CDD:291067	14/29 (48%)
		zf-RING_2	224..266	CDD:290367	22/41 (54%)
		RING	<250..288	CDD:302633	19/26 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4087
OMA	1	1.010	-	-		QHG46695
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	1	1.000	-	-		FOG0000184
OrthoInspector	1	1.000	-	-		otm24792
orthoMCL	1	0.900	-	-		OOG6_102823
Panther	1	1.100	-	-	O	PTHR15710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X390
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.940