DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and Rnf43

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	72/343 - (20%)
Similarity:	117/343 - (34%)	Gaps:	115/343 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LLNMRNVPNLE------ITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAGGRVRPANLDRLDNVL 161
            |.|..:..|||      :.:|..||...         |..|.:::...||.|...|       ||
  Rat    90 LCNASDDDNLEPGFISIVKLESPRRAPR---------PCLSLASKARMAGERGASA-------VL 138

  Fly   162 FDFLQSLPLA-------GATAEIVTGPGGGGVGGGGNSHM--FFMGNPGDY---------AWGRE 208
            ||..:....|       |.|..:|.      :.|.....:  |...|...|         ||...
  Rat   139 FDITEDRSAAEQLQQPLGLTKPVVL------IWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANY 197

  Fly   209 GLDTIVT--------------QMLNQMETSGPPPL---SAQRINEIPNVQINAEEVNRKIQ---- 252
            .:..::|              ::..:...|.|.||   :|:.|:::...:..|.....:.:
  Rat   198 DVWILLTVVGTVFVIILASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWPDS 262

  Fly   253 ---------CSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDADDEF 308
                     |:||.::|...:.:|.:.|.|.:|..|:.|||:.|.|||:|..::.:.
  Rat   263 GSSSSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEG-------- 319

  Fly   309 VMLDAFGPEMAADGSNSE--RR-----------------------SASTATGTDNPSPANNPSQA 348
               |:|...:.|..|..|  ||                       |.::...|..|.|. .|||.
  Rat   320 ---DSFSQALGASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRNSVAQTPRPRPF-LPSQE 380

  Fly   349 AAEGGRTR--PDANPAQA 364
            .:.|.|.:  |.|:..:|
  Rat   381 PSMGSRHQRLPRASHLRA 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030
		RING-H2_RNF126_like	252..294	CDD:319581	16/54 (30%)
		HRD1	<253..372	CDD:227568	36/139 (26%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	16/39 (41%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	26/118 (22%)
		RING-H2_RNF43	270..316	CDD:319712	17/45 (38%)
		dnaA	598..>743	CDD:237605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910