Protein Alignment Iru and RNF115

DIOPT Version :9

• Sequence 1: NP_649859.1
• Gene: Iru / 41080
• FlyBaseID: FBgn0037653
• Length: 380
• Species: Drosophila melanogaster
• Sequence 2: NP_055270.1
• Gene: RNF115 / 27246
• HGNCID: 18154
• Length: 304
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 113/362 - (31%)
• Similarity: 156/362 - (43%)
• Gaps: 80/362 - (22%)

  Fly     1 MAEAMVV---EDRPAEAKRFFCHMCNVEINIPNSDFTCPLCANGFVEELPANAPEMDSSTAGASG 62
            ||||...   ......|.|||||.|..|::....::.||.|.:||:||:..     |||..|..|
Human     1 MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTD-----DSSFLGGGG 60

  Fly    63 SARSGSSGSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMRNVPNLEITIEPNRRHSNVLH 127
            |....::.:..:.....|.........:..:.|      |.|:..|..|       .|.|.....
Human    61 SRIDNTTTTHFAELWGHLDHTMFFQDFRPFLSS------SPLDQDNRAN-------ERGHQTHTD 112

  Fly   128 LGGFGGPSGSDSARGLTAGGRVRPANLDRLDNVLFDFLQSLPLAGATAEIVTG-------PGGGG 185
            ..|...|.       |..|.|.|.....|.|       :|..:.|....|..|       |
Human   113 FWGARPPR-------LPLGRRYRSRGSSRPD-------RSPAIEGILQHIFAGFFANSAIP---- 159

  Fly   186 VGGGGNSHMF-----FMGNPGDYAWGREGLDTIVTQMLNQMETSGPPPLSAQRINEIPNVQINAE 245
                |:.|.|     ...||||||||:.|||.||||:|.|:|.:||||...::|..:|.|.:..|
Human   160 ----GSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQE 220

  Fly   246 EVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDADDEFVM 310
            :|:..::|.:|.:|:.::|.||:|||:|.:|.:||||||.||.|||:|||||
Human   221 QVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSL------------- 272

  Fly   311 LDAFGPEMAADGSNSERRSASTATGTDNPSPANNPSQ 347
                      :|.:|.|:|.||.....|  ..:|.||
Human   273 ----------NGEDSTRQSQSTEASASN--RFSNDSQ 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030	13/29 (45%)
		RING-H2_RNF126_like	252..294	CDD:319581	22/41 (54%)
		HRD1	<253..372	CDD:227568	37/95 (39%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	22/39 (56%)
RNF115	NP_055270.1	zinc_ribbon_9	19..49	CDD:316857	13/29 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..138		13/63 (21%)
		RING-H2_RNF115	226..272	CDD:319714	25/45 (56%)
		RING-H2 finger (C3H2C3-type)	228..268	CDD:319714	22/39 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..304		11/51 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9271
eggNOG	1	0.900	-	-		E33208_3BCP6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4251
Isobase	1	0.950	-	0	Normalized mean entropy	S4957
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	1	1.000	-	-		FOG0000184
OrthoInspector	1	1.000	-	-		otm41324
orthoMCL	1	0.900	-	-		OOG6_102823
Panther	1	1.100	-	-	LDO	PTHR15710
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1936
SonicParanoid	1	1.000	-	-		X390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.850