DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and Rnf43

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus

Alignment Length:	331	Identity:	72/331 - (21%)
Similarity:	109/331 - (32%)	Gaps:	113/331 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LLNMRNVPNLE------ITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAGGRVRPANLDRLDNVL 161
            |.|..:..|||      :.:|..||...         |..|.:::...||.|...|       ||
Mouse    90 LCNASDDDNLEPGFISIVKLESPRRAPR---------PCLSLASKARMAGERGANA-------VL 138

  Fly   162 FDFLQSLPLA-------GATAEIVTGPGGGGVGGGGNSHM--FFMGNPGDYAW-----GREGLDT 212
            ||..:....|       |.|..:|.      :.|...:.:  |...|...|.|     ...|.:.
Mouse   139 FDITEDRSAAEQLQQPLGLTKPVVL------IWGSDAAKLMEFVYKNRKAYVWIELKEPPAGANY 197

  Fly   213 IVTQMLNQMET------------------SGPPPL---SAQRINEIPNVQINA------------ 244
            .|..:|..:.|                  |.|.||   :|:.|:::...:..|
Mouse   198 DVWILLTVVGTVFVIILASVLRIRCRPHHSRPDPLQQRTARAISQLATRRYQAGCRRARAEWPDS 262

  Fly   245 -EEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDADDEF 308
             ...:....|:||.::|...:.:|.:.|.|.:|..|:.|||..|.|||:|..::.:.
Mouse   263 GSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEG-------- 319

  Fly   309 VMLDAFGPEMAADGSNSE--RR-----------------------SASTATGTDNPSPANNPSQA 348
               |:|....||..|..|  ||                       |.::...|..|.|. .|||.
Mouse   320 ---DSFSQAPAASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPF-LPSQE 380

  Fly   349 AAEGGR 354
            .:.|.|
Mouse   381 PSMGSR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030
		RING-H2_RNF126_like	252..294	CDD:319581	16/41 (39%)
		HRD1	<253..372	CDD:227568	34/127 (27%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	16/39 (41%)
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	16/41 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910