DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iru and RNF215

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_001017981.1	Gene:	RNF215 / 200312	HGNCID:	33434	Length:	377	Species:	Homo sapiens

Alignment Length:	344	Identity:	75/344 - (21%)
Similarity:	120/344 - (34%)	Gaps:	101/344 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AGASGSARSGSSGSGSSGS---------HDTLSRGSSSSGSQVNVESLRNDIVSLLNMRNVPNLE 113
            |.|.||..:..:|.|.:.:         .|.|.......||:.:...|....:.|:::.:... |
Human    41 AAADGSEPAAGAGRGGARAVRVDVRLPRQDALVLEGVRIGSEADPAPLLGGRLLLMDIVDAEQ-E 104

  Fly   114 ITIE-------PNRRHSNVLHLGGFG-GPSGSDSA------RGLTAGGR-----------VRPAN 153
            ..:|       ..:..:...|....| ||.....|      |.|..|..           ||..:
Human   105 APVEGWIAVAYVGKEQAAQFHQENKGSGPQAYPKALVQQMRRALFLGASALLLLILNHNVVRELD 169

  Fly   154 LDRL-----------DNV--LFDFLQSLPLAGATAEIVTGP----------------GGGGVGGG 189
            :.:|           .||  |.|.|  |....|||||.:|.                |....|.|
Human   170 ISQLLLRPVIVLHYSSNVTKLLDAL--LQRTQATAEITSGESLSANIEWKLTLWTTCGLSKDGYG 232

  Fly   190 GNSHMFFMGNPGDYAWGREGLDTIVTQML---------------------NQMETSGPPPLSAQR 233
            |...:..:|  |..|..::.|..:...:|                     :|.|..|...|..:|
Human   233 GWQDLVCLG--GSRAQEQKPLQQLWNAILLVAMLLCTGLVVQAQRQASRQSQRELGGQVDLFKRR 295

  Fly   234 -INEIPNVQINAEEVNRKIQ---------CSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHS 288
             :..:.:::.....::|..|         |::|.|.|...:.:|.|||.|.:|.:|:.|||.|..
Human   296 VVRRLASLKTRRCRLSRAAQGLPDPGAETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQ 360

  Fly   289 TCPICRKSLADDGNDADDE 307
            |||:|:.::.  ||...|:
Human   361 TCPLCKFNVL--GNRYSDD 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030
		RING-H2_RNF126_like	252..294	CDD:319581	19/50 (38%)
		HRD1	<253..372	CDD:227568	22/55 (40%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	18/39 (46%)
RNF215	NP_001017981.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
RNF215	NP_001017981.1	zf-RING_2	323..366	CDD:290367	18/42 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910