DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and Pja2

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_620251.1	Gene:	Pja2 / 192256	RGDID:	620273	Length:	707	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	81/399 - (20%)
Similarity:	132/399 - (33%)	Gaps:	134/399 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PAEAKRF--------------------FCHMCNVEINIPNSDFTCPLCANGFVEELPANAP---- 51
            |.||:|.                    |.:.|.....:.:.|.....|::|   |..|:.|
  Rat   382 PREAERHRATAENGATASGRQEARENAFWNACGEYYQLFDKDEDSSECSDG---EWSASLPHRFS 443

  Fly    52 --EMDSSTAGASGSARSGSS------GSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMRN 108
              |.|.|::..|.....|..      .|.|||..:.....|...|.|.::|.           ..
  Rat   444 GTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEE-----------GE 497

  Fly   109 VPNLEITIEPNRRHSNVLHLGGFGGPSGSDSARGLTAGGRVRPAN---------LDRLDNV---- 160
            :|.|:.. |.|.              |.||...        .|||         ||..:|:
  Rat   498 IPWLQYN-EVNE--------------SSSDEGN--------EPANEFAQPEAFMLDGNNNLEDDS 539

  Fly   161 -----------LFD-FLQSLPLAGATAEIVTGPGGGGVGGGGNSHMFFMGNPGDYAWGREGLDTI 213
                       ||| |...|.:|.|.:.:            ....:.:|......|...|.....
  Rat   540 SVSEDLDVDWSLFDGFADGLGVAEAISYV------------DPQFLTYMALEERLAQAMETALAH 592

  Fly   214 VTQMLNQMETSGPPPLSAQRINEIPNVQINAEE--VNRKIQCSICWDDFKIDETVRKLPCSHLYH 276
            :..:...:|.:. ||.|.:.|:.:|...:..:.  :.::..|.||..::..|:...:|||.|.:|
  Rat   593 LESLAVDVEVAN-PPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFH 656

  Fly   277 ENCIVPWLNLHSTCPICRKSLADDGNDADDEFVMLDAFGPEMAADGSNSERRSASTATGTD-NPS 340
            :.|:..||....|||:||:....         .::||               ||:.::..| :.|
  Rat   657 KPCVSIWLQKSGTCPVCRRHFPP---------AVIDA---------------SAAASSEPDLDAS 697

  Fly   341 PANNPSQAA 349
            |||:.::.|
  Rat   698 PANDNAEEA 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030	6/49 (12%)
		RING-H2_RNF126_like	252..294	CDD:319581	15/41 (37%)
		HRD1	<253..372	CDD:227568	27/98 (28%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	15/39 (38%)
Pja2	NP_620251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..120
		PRK11151	210..>241	CDD:182999
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..290
		MDN1	<269..628	CDD:227596	54/295 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..403		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..493		17/71 (24%)
		Interaction with PRKAR1A, PRKAR2A and PRKAR2B. /evidence=ECO:0000250	530..707		45/214 (21%)
		RING-H2_PJA1_2	632..677	CDD:319379	17/44 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..707		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1249953at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920