DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Iru and rnf6

DIOPT Version :9

Sequence 1:	NP_649859.1	Gene:	Iru / 41080	FlyBaseID:	FBgn0037653	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	XP_017209360.1	Gene:	rnf6 / 100359398	ZFINID:	ZDB-GENE-100209-1	Length:	799	Species:	Danio rerio

Alignment Length:	290	Identity:	75/290 - (25%)
Similarity:	113/290 - (38%)	Gaps:	66/290 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PANAPEMDSSTAGASGSARSGSS----GSGSSGSHDTLSRGSSSSGSQVNVESLRNDIVSLLNMR 107
            |....:.||..:.....||:..:    .|.|.|...|:|| |..:|.:..|.::|
Zfish   531 PGENRDRDSIASRTRSRARAAENTVTFESDSGGFRRTISR-SERAGIRTYVSTIR---------- 584

  Fly   108 NVPNLEITIEPNRRHSNVLHLGGFGGPSGSDSARG-----LTAGGRVRPANLDRLDNVLFDFLQ- 166
                     .|.||.|..    |.|.|| |.:.|.     :|..|.:........|:......|
Zfish   585 ---------IPLRRISET----GLGEPS-SMALRSILRQIMTGFGELSSLMETEADSETATPSQD 635

  Fly   167 SLPLAGATAEIVTGPGGGGVGGGGNSHMFFMG---NPGDYAWGREG---------LDTIVTQ--- 216
            |.|.|||......|..||...||..|....:|   ..|.....|.|         .:.:|..
Zfish   636 SAPAAGAQTYRAAGAEGGATHGGVESARETLGEGEEEGQVRVSRTGPEGRPSSRDTNNLVENGTL 700

  Fly   217 ---------MLNQME-TSGPPPLSAQRINEIPN---VQINAE-EVNRKIQCSICWDDFKIDETVR 267
                     :||:.| ...|..|:.::|:.:..   .|:|.| |..|  .||:|.:::.....:|
Zfish   701 PILRLAHFFLLNEDEDEEHPRGLTKEQIDNLVTRTYGQVNLEGEQGR--ACSVCINEYAQGNKLR 763

  Fly   268 KLPCSHLYHENCIVPWLNLHSTCPICRKSL 297
            :|||:|.:|.:||..||:.::||||||:.:
Zfish   764 RLPCAHEFHIHCIDRWLSENNTCPICRQPI 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iru	NP_649859.1	zinc_ribbon_9	16..46	CDD:373030
		RING-H2_RNF126_like	252..294	CDD:319581	17/41 (41%)
		HRD1	<253..372	CDD:227568	19/45 (42%)
		RING-H2 finger (C3H2C3-type)	253..293	CDD:319581	16/39 (41%)
rnf6	XP_017209360.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910