DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta3 and PSMB3

DIOPT Version :9

Sequence 1:	NP_649858.1	Gene:	Prosbeta3 / 41079	FlyBaseID:	FBgn0026380	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_002786.2	Gene:	PSMB3 / 5691	HGNCID:	9540	Length:	205	Species:	Homo sapiens

Alignment Length:	205	Identity:	131/205 - (63%)
Similarity:	170/205 - (82%)	Gaps:	0/205 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSILAYNGGCVVAMRGKDCVAIATDHRFGIQAQTISTDFKKVFHIGPRMFLGLTGLQTDILTVRD 65
            |||::||||.|:||:||:|||||.|.|||||||.::|||:|:|.:|.|:::||.||.||:.||..
Human     1 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQ 65

  Fly    66 RLMFRKNLYETRENREMCPKPFSAMMSSFLYEHRFGPYFIEPVVAGLDPKTMEPFICNMDLIGCP 130
            ||.||.||||.:|.|::.|....:|:::.|||.|||||:.|||:|||||||.:||||::||||||
Human    66 RLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCP 130

  Fly   131 NAPDDFVVAGTCAEQLYGMCETLWKPDLEPDQLFEVIAQSIVNAFDRDAMSGWGATVYIIEKDKI 195
            ...|||||:||||||:|||||:||:|:::||.|||.|:|:::||.||||:||.|..|:|||||||
Human   131 MVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKI 195

  Fly   196 TERTLKTRMD 205
            |.||||.|||
Human   196 TTRTLKARMD 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta3	NP_649858.1	proteasome_beta_type_3	6..201	CDD:239728	123/194 (63%)
PSMB3	NP_002786.2	proteasome_beta_type_3	6..201	CDD:239728	123/194 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140718
Domainoid	1	1.000	256	1.000	Domainoid score	I2039
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2089
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2823
Isobase	1	0.950	-	0	Normalized mean entropy	S357
OMA	1	1.010	-	-		QHG53924
OrthoDB	1	1.010	-	-		D1170036at2759
OrthoFinder	1	1.000	-	-		FOG0003566
OrthoInspector	1	1.000	-	-		oto88410
orthoMCL	1	0.900	-	-		OOG6_101970
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1011
SonicParanoid	1	1.000	-	-		X2440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790