DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31100 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_001262395.1	Gene:	CG31100 / 41075	FlyBaseID:	FBgn0051100	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_849265.2	Gene:	Slc2a12 / 353169	MGIID:	3052471	Length:	622	Species:	Mus musculus

Alignment Length:	670	Identity:	141/670 - (21%)
Similarity:	232/670 - (34%)	Gaps:	198/670 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FPTIVIPAIQG---GEGRSETSGDIL-------LNKDEISWFSSINLICVPLGCLFSGLLTQPLG 124
            |.|.|..||.|   |......||.:|       |...|.....|..||...|..|..|:|....|
Mouse    45 FLTSVTAAISGLLVGYELGLISGALLQIRTLLALTCHEQEMVVSSLLIGAFLASLTGGVLIDRYG 109

  Fly   125 KRRAMQFVNLPILAAWLMFHFATRTEHLYAALCLAGLGG-----------------------GLM 166
            :|.|:      ||::                 ||.|||.                       .|.
Mouse   110 RRLAI------ILSS-----------------CLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLS 151

  Fly   167 EAPVLTYVAEITEPKYRGILSALGTTCVITGVFIQFILGSLM-----DWRSVAAVSSAFPVITII 226
            ......|:|||.....||:|.:|....::||:...:|.....     .|:.:..:.....|:..|
Mouse   152 SIATCVYIAEIAPQHRRGLLVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAI 216

  Fly   227 MLCFVPESPVWLIREQRFREAVKSLQWLR--GWVPEHM------IEAEFNQLYDELITQKAIELS 283
            .:.|:|.||.:|:.:.:...|.|.|:.||  ....|.:      ::.|:...:.:|...|.
Mouse   217 AMYFLPPSPRFLVMKGQEESAGKVLRKLRVISDTTEELTLIKSSLKDEYQYSFWDLFRSKD---- 277

  Fly   284 ADGIPPPGQRRTLGQRLRMWRKRSFLVPFLLVSFSFFTGH----FSGKTPLQTYAVQIFHTLKAP 344
                         ..|.|:      |:...||.|...||.    |...|.|::...|.......
Mouse   278 -------------NMRTRI------LIGLTLVFFVQTTGQPNILFYASTVLKSVGFQSNEAASL- 322

  Fly   345 MNKYHATILLGVAEMLATILGVVLIHFTGKRPLVLVSTVGTGLCFFGTATYAHFLSEVPGFTVNN 409
                 |:..:||.::::||...:|:...|.:         |.||...:...|..|:  .|....|
Mouse   323 -----ASTGVGVVKVVSTIPATLLVDHIGSK---------TFLCIGSSVMSASLLT--MGIVNLN 371

  Fly   410 VVVNASSIMPKEGILSQQNISKIF------ETEQQAIRQETERFTTQLPDIETTTLFDQEIYNRS 468
            :.:|.::|.....:|:|.....:|      .....::|:..:|.|.               |::.
Mouse   372 INMNFTNICRSHSLLNQSLEEFVFYATGNLSISNSSLREHFKRITP---------------YSKG 421

  Fly   469 RRDVVEMMTTDAPMDTTMWPEPSSSPEPIASSSLAPPSTSVKPPLVEELLLVVPKQEHNYLV--- 530
                     :..||...|.|:    .|...:|||  |:..:.            :.||..:.
Mouse   422 ---------SFMPMGNGMEPK----GEMTFTSSL--PNAGLS------------RTEHQGVTDTA 459

  Fly   531 -------WVPLILLLLSAFFSHLGIRMLPWILIGEVFPAEIRNSASGFAGGVGYIFGFLANKLFL 588
                   |:.|..||:......:|:..:||:::.|:||..||..|......:.:....|.:..||
Mouse   460 VVPAAYKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGVNLLISLTFL 524

  Fly   589 LMLSALTLPGTFAFY-----ASVAFFGTVVLYFTLPETEGRTLGEIEAHFSKKSDV--------- 639
            .:...:.|......|     ||:||   |||:  :|||:|.:|.:|....:|.:.|
Mouse   525 TVTDLIGLSWVCFIYTIMSLASLAF---VVLF--IPETKGCSLEQISVELAKANYVKNNICFMSH 584

  Fly   640 --------NLLRKQPSNKLP 651
                    .|.:::|..:||
Mouse   585 HQEELVPTQLQKRKPQEQLP 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31100	NP_001262395.1	MFS	59..>232	CDD:119392	45/199 (23%)
		Sugar_tr	98..633	CDD:278511	123/595 (21%)
		MFS	<531..616	CDD:119392	25/89 (28%)
Slc2a12	NP_849265.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sugar_tr	48..569	CDD:278511	133/630 (21%)
		MFS	49..>367	CDD:119392	80/380 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9576
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910