Protein Alignment CG31100 and SLC2A8

DIOPT Version :9

• Sequence 1: NP_001262395.1
• Gene: CG31100 / 41075
• FlyBaseID: FBgn0051100
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_055395.2
• Gene: SLC2A8 / 29988
• HGNCID: 13812
• Length: 477
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 127/593 - (21%)
• Similarity: 234/593 - (39%)
• Gaps: 155/593 - (26%)

  Fly    51 FLAVSIKNILLFGYGMTLGFPTIVIPAIQGGEGRSETSGDILLNKDEISWFSSINLICVPLGCLF 115
            |||.....:....:|..||:.:..||::|.....:..     |:....|||.::..:....|.:.
Human    27 FLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPR-----LDDAAASWFGAVVTLGAAAGGVL 86

  Fly   116 SGLLTQPLGKRRAMQFVNLPILAAWLMFHFATRTEHLYAALCLAGLGGGL--MEAPVLTYVAEIT 178
            .|.|....|::.::...::|.:|.:.:...|.....|.....|.||..|:  :.|||  |::||.
Human    87 GGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPV--YISEIA 149

  Fly   179 EPKYRGILSALGTTCVITGVFIQFILGSLMDWRSVAAVSSAFPVITIIMLCFVPESPVWLIREQR 243
            .|..||:|.:.....|:.|:.:.::.|.:::||.:|.:....|.:.::::||:||:|.:|:.:.|
Human   150 YPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHR 214

  Fly   244 FREAVKSLQWL----RGWVPEHMIEAEFNQLYDELITQKAIELSADGIPPPGQRRTLGQRLRMWR 304
            .:||:.:|::|    :||..                            ||.|..::.  .|.:.|
Human   215 RQEAMAALRFLWGSEQGWED----------------------------PPIGAEQSF--HLALLR 249

  Fly   305 KRSFLVPFLL-VSFSFFTGHFSGKTPLQTYAVQIFHTLKAPMNKYHATILLGVAEMLATILGVVL 368
            :.....||:: ||...|. ..||...:..||..||...|...:.. |::::||.::|.|.:..::
Human   250 QPGIYKPFIIGVSLMAFQ-QLSGVNAVMFYAETIFEEAKFKDSSL-ASVVVGVIQVLFTAVAALI 312

  Fly   369 IHFTGKRPLVLVSTVGTGLCFFGTATYAHFLSEVPGFTVNNVVVNASSIMPKEGILSQQNISKIF 433
            :...|:|.|:::|.|   :..|.|:.:..:.....|...|:..|..|
Human   313 MDRAGRRLLLVLSGV---VMVFSTSAFGAYFKLTQGGPGNSSHVAIS------------------ 356

  Fly   434 ETEQQAIRQETERFTTQLPDIETTTLFDQEIYNRSRRDVVEMMTTDAPMDTTMWPEPSSSPEPI- 497
                                                          ||:          |.:|:
Human   357 ----------------------------------------------APV----------SAQPVD 365

  Fly   498 ASSSLAPPSTSVKPPLVEELLLVVPKQEHNYLVWVPL--ILLLLSAFFSHLGIRMLPWILIGEVF 560
            ||..||                           |:.:  :.|.::.|  .:|...:||:|:.|:|
Human   366 ASVGLA---------------------------WLAVGSMCLFIAGF--AVGWGPIPWLLMSEIF 401

  Fly   561 PAEIRNSASGFAGGVGYIFGFLANKLFLLMLSALTLPGTFAFYASVAFFGTVVLYFTLPETEGRT 625
            |..::..|:|......::..||..|.|..::..|...|.|...::...|..:...|.:|||:|:|
Human   402 PLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKT 466

  Fly   626 LGEIEAHF 633
            |.:|.|||
Human   467 LEQITAHF 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31100	NP_001262395.1	MFS	59..>232	CDD:119392	41/174 (24%)
		Sugar_tr	98..633	CDD:278511	115/544 (21%)
		MFS	<531..616	CDD:119392	20/86 (23%)
SLC2A8	NP_055395.2	Dileucine internalization motif. /evidence=ECO:0000250|UniProtKB:Q9JJZ1	12..13
		xylE	36..472	CDD:182225	121/580 (21%)
		MFS	38..459	CDD:119392	114/565 (20%)
		Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166	267..273		2/6 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920