DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31100 and SLC2A12

DIOPT Version :9

Sequence 1:	NP_001262395.1	Gene:	CG31100 / 41075	FlyBaseID:	FBgn0051100	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_660159.1	Gene:	SLC2A12 / 154091	HGNCID:	18067	Length:	617	Species:	Homo sapiens

Alignment Length:	666	Identity:	137/666 - (20%)
Similarity:	232/666 - (34%)	Gaps:	183/666 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GYGMTLGFPTIVIPAIQG---GEGRSETSGDIL-------LNKDEISWFSSINLICVPLGCLFSG 117
            |.|| ..|.:.|..|:.|   |......||.:|       |:..|.....|..:|...|..|..|
Human    35 GCGM-FTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGG 98

  Fly   118 LLTQPLGKRRAMQFVNLPILAAWLMFHFATRTEHLYAALCLAGLGG------------------- 163
            :|....|:|.|:      ||::                 ||.|||.
Human    99 VLIDRYGRRTAI------ILSS-----------------CLLGLGSLVLILSLSYTVLIVGRIAI 140

  Fly   164 ----GLMEAPVLTYVAEITEPKYRGILSALGTTCVITGVFIQFI-----LGSLMDWRSVAAVSSA 219
                .|.......|:|||.....||:|.:|....::.|:...:|     ......|:.:..:...
Human   141 GVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIP 205

  Fly   220 FPVITIIMLCFVPESPVWLIREQRFREAVKSLQWLRG--------WVPEHMIEAEFNQLYDELIT 276
            ..|:..|.:.|:|.||.:|:.:.:...|.|.|..||.        .|.:..::.|:...:.:|..
Human   206 LGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFR 270

  Fly   277 QKAIELSADGIPPPGQRRTLGQRLRMWRKRSFLVPFLLVSFSFFTGH----FSGKTPLQTYAVQI 337
            .|.                 ..|.|:      ::...||.|...||.    |...|.|::...|.
Human   271 SKD-----------------NMRTRI------MIGLTLVFFVQITGQPNILFYASTVLKSVGFQS 312

  Fly   338 FHTLKAPMNKYHATILLGVAEMLATILGVVLIHFTGKRPLVLVSTVGTGLCFFGTATYAHFLSEV 402
            ......      |:..:||.::::||...:|:...|.:         |.|| .|::..|..|..:
Human   313 NEAASL------ASTGVGVVKVISTIPATLLVDHVGSK---------TFLC-IGSSVMAASLVTM 361

  Fly   403 PGFTVNNVVVNASSIMPKEGILSQQ----------NISKIFETEQQAIRQETERFTTQLPDIETT 457
             |....|:.:|.:.|......::|.          |:|    |....:|...:..::
Human   362 -GIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLS----TNNNTLRDHFKGISS-------- 413

  Fly   458 TLFDQEIYNRS-----RRDVVEMMTTDAPMDTTMWPEPSSSPEPIASSSLAPPSTSVKPPLVEEL 517
                   ::||     |.||      |...:||             |:||.....|    ..|..
Human   414 -------HSRSSLMPLRNDV------DKRGETT-------------SASLLNAGLS----HTEYQ 448

  Fly   518 LLVVPKQEHNYLVWVPLILLLLSAFFSHLGIRMLPWILIGEVFPAEIRNSASGFAGGVGYIFGFL 582
            ::..|.....:|.|:.|..||:......:|:..:||:::.|:||..||..|......:.:....|
Human   449 IVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLL 513

  Fly   583 ANKLFLLMLSALTLPGTFAFYASVAFFGTVVLYFTLPETEGRTLGEIEAHFSK----KSDV---- 639
            .:..||.:...:.||.....|..::....:.:...:|||:|.:|.:|....:|    |:::
Human   514 ISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMS 578

  Fly   640 ----NLLRKQPSNKLP 651
                .|:.|||..:.|
Human   579 HHQEELVPKQPQKRKP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31100	NP_001262395.1	MFS	59..>232	CDD:119392	44/206 (21%)
		Sugar_tr	98..633	CDD:278511	117/589 (20%)
		MFS	<531..616	CDD:119392	19/84 (23%)
SLC2A12	NP_660159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
SLC2A12	NP_660159.1	Sugar_tr	44..561	CDD:306568	125/621 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9615
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820