DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and ATG18D

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_191203.2	Gene:	ATG18D / 824811	AraportID:	AT3G56440	Length:	391	Species:	Arabidopsis thaliana

Alignment Length:	351	Identity:	147/351 - (41%)
Similarity:	198/351 - (56%)	Gaps:	45/351 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLYAAFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSHVEMLFRCNYLALVGGGIRPLY 77
            |:..::|||..|||..|..|||:|||:|.||..|:...:||...||||||.|.|||||||....|
plant    36 LVSVSWNQDYSCFAAGTSHGFRIYNCEPFKETFRRELKDGGFKIVEMLFRSNILALVGGGPNSQY 100

  Fly    78 PPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPN 142
            |.|||::|||.:........|...:|||:|||||||||||..|.|:.| ...:.||..|..:||.
plant   101 PSNKVLIWDDHQGRCISEFTFRSEIRAVKLRRDRIVVVLEHKIYVYNF-MDLRLLHQIENMANPR 164

  Fly   143 GLCVLCPHSNKSLLAFPGRRTGHVQIVDLANTERAPLEVI----AHEAGISCIALNLQGTRLATA 203
            |||.|..|.|.|:||.||.|.|.|::      |...|.::    ||::.|:|:.|.|.|..||||
plant   165 GLCCLSHHMNTSVLACPGIRRGEVRV------EHFGLNMVQIINAHDSNIACMTLTLDGLLLATA 223

  Fly   204 GEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNL------EDN 262
            ..||||||||:|..|.::.|:|||.:.|:|:.|..:.....:.|:||.||:|:|:|      ||.
plant   224 STKGTLIRIFNTMDGTRLQEVRRGVDRADIYSIALSPNVQWLAVSSDKGTVHIFSLRVRVIGEDA 288

  Fly   263 KPRE---------------------SSLP----IIPKYFSSQWSFVKFSIPQGPRCVCAFGADPN 302
            ...|                     |||.    ::||||||:|||.:|.:|:..:...||||. |
plant   289 YSTEHETSSNSLQPLVSPASGANPGSSLSFLRGVLPKYFSSEWSFSQFHVPEVTQYFAAFGAQ-N 352

  Fly   303 SVVAICADGHYYKFLFN--NKGECSR 326
            ::..|..||.:|:..|:  |.||.::
plant   353 TIAIIGLDGSFYRCNFDPVNGGEMTQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	19/33 (58%)
		WD40	141..>265	CDD:421866	55/133 (41%)
		WD40 repeat	145..180	CDD:293791	13/34 (38%)
		WD40 repeat	188..225	CDD:293791	20/36 (56%)
		WD40 repeat	233..273	CDD:293791	16/70 (23%)
ATG18D	NP_191203.2	WD40	33..373	CDD:225201	144/344 (42%)
		WD40 repeat	38..74	CDD:293791	17/35 (49%)
		WD40 repeat	80..121	CDD:293791	22/40 (55%)
		WD40	<91..278	CDD:295369	86/193 (45%)
		WD40 repeat	125..162	CDD:293791	20/37 (54%)
		WD40 repeat	167..202	CDD:293791	14/40 (35%)
		WD40 repeat	208..245	CDD:293791	20/36 (56%)
		WD40 repeat	253..279	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I552
eggNOG	1	0.900	-	-		E1_KOG2111
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6028
Inparanoid	1	1.050	255	1.000	Inparanoid score	I1004
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D966922at2759
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	1	1.000	-	-		otm3051
orthoMCL	1	0.900	-	-		OOG6_102082
Panther	1	1.100	-	-	O	PTHR11227
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840