DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and Wdr45b

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_080069.2	Gene:	Wdr45b / 66840	MGIID:	1914090	Length:	344	Species:	Mus musculus

Alignment Length:	343	Identity:	233/343 - (67%)
Similarity:	278/343 - (81%)	Gaps:	4/343 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLTEQNPYGNGLLYAAFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSHVEMLFRCNY 65
            |||...||:|||||||.||||.|||||..:.||||||.|||||||:|.|.|||:.||||||||||
Mouse     1 MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNY 65

  Fly    66 LALVGGGIRPLYPPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQ 130
            |||||||.:|.||||||::||||||...|.::|:..|:||:||||||||||:.:|||||||..|.
Mouse    66 LALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPH 130

  Fly   131 QLHVFETSSNPNGLCVLCPHSNKSLLAFPGRRTGHVQIVDLANTERAPLEVIAHEAGISCIALNL 195
            |||||||..||.|||||||:||.|||||||..|||||:||||:||:.|:::.|||..:|||||||
Mouse   131 QLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNL 195

  Fly   196 QGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNLE 260
            ||||:|||.|||||||||||.||..:.||||||..|||:|||||..::::.|:|||||:|:|..|
Mouse   196 QGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAE 260

  Fly   261 DNK-PRESSL---PIIPKYFSSQWSFVKFSIPQGPRCVCAFGADPNSVVAICADGHYYKFLFNNK 321
            |.| .::|||   ..:||||||:|||.||.:|.|..|:||||.:||:|:||||||.||||||:.|
Mouse   261 DPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFSPK 325

  Fly   322 GECSRDICTQFLELQDDE 339
            |||.||:|.||||:.||:
Mouse   326 GECVRDVCAQFLEMTDDK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	25/33 (76%)
		WD40	141..>265	CDD:421866	84/124 (68%)
		WD40 repeat	145..180	CDD:293791	26/34 (76%)
		WD40 repeat	188..225	CDD:293791	28/36 (78%)
		WD40 repeat	233..273	CDD:293791	20/43 (47%)
Wdr45b	NP_080069.2	WD40	<25..258	CDD:421866	162/232 (70%)
		WD40 repeat	102..126	CDD:293791	18/23 (78%)
		WD40 repeat	145..183	CDD:293791	26/37 (70%)
		WD 1	183..223		30/39 (77%)
		WD40 repeat	188..225	CDD:293791	28/36 (78%)
		WD 2	228..267		20/38 (53%)
		WD40 repeat	234..267	CDD:293791	16/32 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845981
Domainoid	1	1.000	498	1.000	Domainoid score	I352
eggNOG	1	0.900	-	-		E1_KOG2111
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6028
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1360
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	1	1.000	-	-		oto95376
orthoMCL	1	0.900	-	-		OOG6_102082
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760