DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and WIPI1

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_060453.3	Gene:	WIPI1 / 55062	HGNCID:	25471	Length:	446	Species:	Homo sapiens

Alignment Length:	340	Identity:	87/340 - (25%)
Similarity:	160/340 - (47%)	Gaps:	41/340 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AFNQDQGCFACATDTGFRVYNCDPLKEKERQY----FPEGGLSHVEMLFRCNYLALVGGGIRPLY 77
            :||||....|..|..|:::::...:::.::.:    .|:  :..||.||..:.:.:|..     .
Human    21 SFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPD--VYIVERLFSSSLVVVVSH-----T 78

  Fly    78 PPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPN 142
            .|.::.|:...|.:...:..::..:.::||.|.|::|.||..|.:...........:.:..:||.
Human    79 KPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPT 143

  Fly   143 GLCVLCPHSNKSLLAFPGRRT-GHVQIVDLANTERAPLEVIAHEAGISCIALNLQGTRLATAGEK 206
            |||.|..:.:.|.||:||..| |.:.:.| .|:.:....:.|||..::.|..|..|::||:|.||
Human   144 GLCALSINHSNSYLAYPGSLTSGEIVLYD-GNSLKTVCTIAAHEGTLAAITFNASGSKLASASEK 207

  Fly   207 GTLIRIFDTESGKKVSELRRG-SNHANIFCINFNHQSTMVVVASDHGTIHVFNLE---DNKPRES 267
            ||:||:|....|:|:.|.||| ..:..|..:.|:..|..:..:|:..|:|:|.||   :::|.|.
Human   208 GTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEP 272

  Fly   268 SL--PIIPKYFSSQWSFVKFSIP----------------QGPRCVCAFGAD---PNSVVAICADG 311
            |.  ..:.|.|.:..:::...:.                .|.|.:|.....   |..:|| .:.|
Human   273 STWSGYMGKMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVA-SSSG 336

  Fly   312 HYYKFLFN--NKGEC 324
            |.|.:..:  :.|||
Human   337 HLYMYNLDPQDGGEC 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	8/33 (24%)
		WD40	141..>265	CDD:421866	45/128 (35%)
		WD40 repeat	145..180	CDD:293791	11/35 (31%)
		WD40 repeat	188..225	CDD:293791	16/36 (44%)
		WD40 repeat	233..273	CDD:293791	12/44 (27%)
WIPI1	NP_060453.3	WD 1	3..42		7/20 (35%)
		WD 2	47..88		8/47 (17%)
		WD40	<77..>262	CDD:225201	55/190 (29%)
		WD40	<88..262	CDD:295369	53/174 (30%)
		WD 3	92..126		8/33 (24%)
		WD 4	131..173		14/42 (33%)
		Nuclear receptor interaction	131..136		0/4 (0%)
		WD40 repeat	145..184	CDD:293791	12/39 (31%)
		WD 5	177..216		16/38 (42%)
		WD40 repeat	189..226	CDD:293791	16/36 (44%)
		WD 6	222..261		11/38 (29%)
		WD40 repeat	236..268	CDD:293791	8/31 (26%)
		WD40 repeat	274..312	CDD:293791	2/37 (5%)
		WD 7	304..343		9/39 (23%)
		WD40 repeat	320..358	CDD:293791	9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950