DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11975 and Wipi1

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_666052.1	Gene:	Wipi1 / 52639	MGIID:	1261864	Length:	446	Species:	Mus musculus

Alignment Length:	342	Identity:	90/342 - (26%)
Similarity:	163/342 - (47%)	Gaps:	45/342 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AFNQDQGCFACATDTGFRVYNCDPLKEKERQY----FPEGGLSHVEMLFRCNYLALVGGGIRPLY 77
            :||||....|..|..|:::::...:::.::.:    .|:  :..||.||..:.:.:|..     .
Mouse    21 SFNQDCTSLAIGTKAGYKLFSLSSVEQLDQVHGSNEIPD--VYIVERLFSSSLVVVVSH-----T 78

  Fly    78 PPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPN 142
            .|.::.|:...|.:...:..::..:.::||.|.|::|.||..|.:...........|.:..|||.
Mouse    79 KPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLDIPSNPT 143

  Fly   143 GLCVLCPHSNKSLLAFPG-RRTGHVQIVDLANTERAPLEVIAHEAGISCIALNLQGTRLATAGEK 206
            |||.|..:.:.|.||:|| :.||.:.:.| .|:.:....:.|||..::.|..|..|::||:|.||
Mouse   144 GLCALSINHSNSYLAYPGSQSTGEIVLYD-GNSLKTVCTIAAHEGTLAAITFNSSGSKLASASEK 207

  Fly   207 GTLIRIFDTESGKKVSELRRG-SNHANIFCINFNHQSTMVVVASDHGTIHVFNLE---DNKPRES 267
            ||:||:|....|:|:.|.||| ..:..|..:.|:..|..:..:|:..|:|:|.:|   |::|.|.
Mouse   208 GTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEHLTDSRPEEP 272

  Fly   268 SL--PIIPKYFSSQWSFVKFSIP----------------QGPRCVCAFGAD---PNSVVAICADG 311
            |.  ..:.|.|.:..:::...:.                .|.:.:|.....   |..:|| .:||
Mouse   273 STWSGYMGKMFMAATNYLPAQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQKLPRLLVA-SSDG 336

  Fly   312 HYYKFLFN----NKGEC 324
            |.|  ::|    :.|||
Mouse   337 HLY--IYNLDPQDGGEC 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	9/33 (27%)
		WD40	141..>265	CDD:421866	45/128 (35%)
		WD40 repeat	145..180	CDD:293791	11/35 (31%)
		WD40 repeat	188..225	CDD:293791	16/36 (44%)
		WD40 repeat	233..273	CDD:293791	12/44 (27%)
Wipi1	NP_666052.1	WD40	<88..262	CDD:295369	55/174 (32%)
		WD40	<100..265	CDD:225201	55/165 (33%)
		Nuclear receptor interaction. /evidence=ECO:0000250	131..136		0/4 (0%)
		WD40 repeat	144..184	CDD:293791	13/40 (33%)
		WD 1	184..224		18/39 (46%)
		WD40 repeat	189..226	CDD:293791	16/36 (44%)
		WD 2	230..269		9/38 (24%)
		WD40 repeat	236..265	CDD:293791	7/28 (25%)
		WD40 repeat	272..312	CDD:293791	3/39 (8%)
		WD 3	312..351		11/41 (27%)
		WD40 repeat	320..358	CDD:293791	11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950