Protein Alignment CG11975 and Wipi1

DIOPT Version :10

• Sequence 1: NP_649853.1
• Gene: CG11975 / 41074
• FlyBaseID: FBgn0037648
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_666052.1
• Gene: Wipi1 / 52639
• MGIID: 1261864
• Length: 446
• Species: Mus musculus
• Alignment Length: 342
• Identity: 90/342 - (26%)
• Similarity: 163/342 - (47%)
• Gaps: 45/342 - (13%)

  Fly    17 AFNQDQGCFACATDTGFRVYNCDPLKEKERQY----FPEGGLSHVEMLFRCNYLALVGGGIRPLY 77
            :||||....|..|..|:::::...:::.::.:    .|:  :..||.||..:.:.:|..     .
Mouse    21 SFNQDCTSLAIGTKAGYKLFSLSSVEQLDQVHGSNEIPD--VYIVERLFSSSLVVVVSH-----T 78

  Fly    78 PPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPN 142
            .|.::.|:...|.:...:..::..:.::||.|.|::|.||..|.:...........|.:..|||.
Mouse    79 KPRQMNVYHFKKGTEICNYSYSSNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTVLDIPSNPT 143

  Fly   143 GLCVLCPHSNKSLLAFPG-RRTGHVQIVDLANTERAPLEVIAHEAGISCIALNLQGTRLATAGEK 206
            |||.|..:.:.|.||:|| :.||.:.:.| .|:.:....:.|||..::.|..|..|::||:|.||
Mouse   144 GLCALSINHSNSYLAYPGSQSTGEIVLYD-GNSLKTVCTIAAHEGTLAAITFNSSGSKLASASEK 207

  Fly   207 GTLIRIFDTESGKKVSELRRG-SNHANIFCINFNHQSTMVVVASDHGTIHVFNLE---DNKPRES 267
            ||:||:|....|:|:.|.||| ..:..|..:.|:..|..:..:|:..|:|:|.:|   |::|.|.
Mouse   208 GTVIRVFSVPEGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKMEHLTDSRPEEP 272

  Fly   268 SL--PIIPKYFSSQWSFVKFSIP----------------QGPRCVCAFGAD---PNSVVAICADG 311
            |.  ..:.|.|.:..:::...:.                .|.:.:|.....   |..:|| .:||
Mouse   273 STWSGYMGKMFMAATNYLPAQVSDMMNQDRAFATGRLNFSGQKNICTLSTIQKLPRLLVA-SSDG 336

  Fly   312 HYYKFLFN----NKGEC 324
            |.|  ::|    :.|||
Mouse   337 HLY--IYNLDPQDGGEC 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_649853.1	WD40	<70..>265	CDD:441893	59/199 (30%)
		WD40 repeat	102..136	CDD:293791	9/33 (27%)
		WD40 repeat	145..180	CDD:293791	11/35 (31%)
		WD40 repeat	188..225	CDD:293791	16/36 (44%)
		WD40 repeat	233..273	CDD:293791	12/44 (27%)
Wipi1	NP_666052.1	WD40	<88..262	CDD:475233	55/174 (32%)
		Nuclear receptor interaction. /evidence=ECO:0000250|UniProtKB:Q5MNZ9	131..136		0/4 (0%)
		WD40 repeat	144..184	CDD:293791	13/40 (33%)
		WD 1	184..224		18/39 (46%)
		WD40 repeat	189..226	CDD:293791	16/36 (44%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	225..228		1/2 (50%)
		WD 2	230..269		9/38 (24%)
		WD40 repeat	236..265	CDD:293791	7/28 (25%)
		WD40 repeat	272..312	CDD:293791	3/39 (8%)
		WD 3	312..351		11/41 (27%)
		WD40 repeat	320..358	CDD:293791	11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..406