DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and wdr45

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_012812316.2	Gene:	wdr45 / 496788	XenbaseID:	XB-GENE-972376	Length:	355	Species:	Xenopus tropicalis

Alignment Length:	352	Identity:	153/352 - (43%)
Similarity:	222/352 - (63%)	Gaps:	29/352 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NGLLYAAFNQDQGCFACATDTGFRVYNCDPLKEK----ERQYFPEGGLSHVEMLFRCNYLALVGG 71
            |||   .|||||.||.||.:||.|::|.:||.||    :.|.   |.:..||||.|||.||||||
Frog     8 NGL---RFNQDQSCFCCAMETGVRIFNIEPLMEKGHLDQEQV---GSVGQVEMLHRCNLLALVGG 66

  Fly    72 GIRPLYPPNKVIVWDDL---KKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLH 133
            |..|.:....|::|||.   |....:...|.:||.:||||.::||:.|:..|.|::|...|.:|.
Frog    67 GSNPKFSDISVLIWDDSRDGKDKLVLEFTFTKPVLSVRLRSEKIVIALKNRIYVYSFPDNPTKLF 131

  Fly   134 VFETSSNPNGLCVLCPHSNKSLLAFPGRRTGHVQIVDLAN----TERAPLEVIAHEAGISCIALN 194
            .|:|..||.|||.|||...|.||.|||.:.|.:|:|||.|    :..||..:.||::.:.|:|:|
Frog   132 EFDTRDNPKGLCDLCPSLEKQLLLFPGHKCGSLQLVDLCNAKPGSSSAPFTINAHQSELGCLAVN 196

  Fly   195 LQGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNL 259
            .|||.:|:|..||||||:|||::.:::.|||||::.|.::||||:|.|:.:..:||.||:|:|.|
Frog   197 QQGTLVASASRKGTLIRLFDTQTREQLVELRRGTDPATLYCINFSHDSSFLCSSSDKGTVHIFAL 261

  Fly   260 EDNK-PRESSL-------PIIPKYFSSQWSFVKFSIPQGPRCVCAFGADP----NSVVAICADGH 312
            :|.| .|.|:|       |:|.:|..||||...|::|....|:||||.:.    |||:|:|.||.
Frog   262 KDTKLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGKNTSKNVNSVIAVCVDGT 326

  Fly   313 YYKFLFNNKGECSRDICTQFLELQDDE 339
            ::|::|..:|.|:|:....:|::.||:
Frog   327 FHKYVFTPEGNCNREAFDVYLDICDDD 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	13/33 (39%)
		WD40	141..>265	CDD:421866	61/128 (48%)
		WD40 repeat	145..180	CDD:293791	18/38 (47%)
		WD40 repeat	188..225	CDD:293791	18/36 (50%)
		WD40 repeat	233..273	CDD:293791	19/47 (40%)
wdr45	XP_012812316.2	WD40 repeat	101..137	CDD:293791	14/35 (40%)
		WD40 repeat	142..182	CDD:293791	19/39 (49%)
		WD40	<182..>269	CDD:421866	40/86 (47%)
		WD40 repeat	191..227	CDD:293791	18/35 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D454738at33208
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960