DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and wdr45b

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_956534.2	Gene:	wdr45b / 393210	ZFINID:	ZDB-GENE-040426-863	Length:	344	Species:	Danio rerio

Alignment Length:	343	Identity:	231/343 - (67%)
Similarity:	276/343 - (80%)	Gaps:	4/343 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLTEQNPYGNGLLYAAFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSHVEMLFRCNY 65
            |||...||:|||||||.||||.|||||..:.||||||.|||||||:|.|.|||:.||||||||||
Zfish     1 MNLLPSNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNY 65

  Fly    66 LALVGGGIRPLYPPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQ 130
            |||||||.:|.||||||::||||||...|.::|:..|:||:||||||||||:.:|||||||..|.
Zfish    66 LALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPH 130

  Fly   131 QLHVFETSSNPNGLCVLCPHSNKSLLAFPGRRTGHVQIVDLANTERAPLEVIAHEAGISCIALNL 195
            |||||||..||.|||||||:||.||||||...:||||||||||||:.|:::.|||..:.||.|||
Zfish   131 QLHVFETCYNPKGLCVLCPNSNNSLLAFPATHSGHVQIVDLANTEKPPVDIPAHEGVLCCITLNL 195

  Fly   196 QGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNLE 260
            ||||:|||.|||||||||||.:|:.:.||||||..|||:|||||..::::.|:|||||:|:|..|
Zfish   196 QGTRIATASEKGTLIRIFDTSAGQLIQELRRGSQTANIYCINFNQDASLICVSSDHGTVHIFAAE 260

  Fly   261 DNK-PRESSL---PIIPKYFSSQWSFVKFSIPQGPRCVCAFGADPNSVVAICADGHYYKFLFNNK 321
            |.| .::|||   ..:||||||:|||.||.:|.|..||||||.:||:|:||||||.|||||||.|
Zfish   261 DPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCVCAFGTEPNAVIAICADGSYYKFLFNPK 325

  Fly   322 GECSRDICTQFLELQDDE 339
            ||||||:..||||:.|::
Zfish   326 GECSRDVYAQFLEMTDEK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	25/33 (76%)
		WD40	141..>265	CDD:421866	81/124 (65%)
		WD40 repeat	145..180	CDD:293791	26/34 (76%)
		WD40 repeat	188..225	CDD:293791	25/36 (69%)
		WD40 repeat	233..273	CDD:293791	20/43 (47%)
wdr45b	NP_956534.2	WD40	34..257	CDD:295369	154/222 (69%)
		WD40	80..>295	CDD:225201	136/214 (64%)
		WD40 repeat	102..126	CDD:293791	18/23 (78%)
		WD40 repeat	145..183	CDD:293791	26/37 (70%)
		WD 1	183..223		27/39 (69%)
		WD40 repeat	188..225	CDD:293791	25/36 (69%)
		WD 2	228..267		20/38 (53%)
		WD40 repeat	234..267	CDD:293791	16/32 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590692
Domainoid	1	1.000	491	1.000	Domainoid score	I361
eggNOG	1	0.900	-	-		E1_KOG2111
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6028
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1372
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D454738at33208
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	1	1.000	-	-		oto38910
orthoMCL	1	0.900	-	-		OOG6_102082
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840