DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and Wdr45

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_006256772.1	Gene:	Wdr45 / 302559	RGDID:	1359718	Length:	361	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	157/365 - (43%)
Similarity:	226/365 - (61%)	Gaps:	39/365 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QNPYGNGLLYAAFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSH--------VEMLFR 62
            |.|. .|:....|||||.||.||.:||.|:||.:||.||       |.|.|        ||||.|
  Rat     3 QQPL-RGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEK-------GHLDHEQVGSVGLVEMLHR 59

  Fly    63 CNYLALVGGGIRPLYPP-NKVIVWDDLKKSP------AISLDFNQPVRAVRLRRDRIVVVLEGVI 120
            .|.|||||||..|.:.. :.|::|||.::..      .:...|.:||.|||:|.|:||:||...|
  Rat    60 SNLLALVGGGSSPKFSEISAVLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRI 124

  Fly   121 KVFTFTQQPQQLHVFETSSNPNGLCVLCPHSNKSLLAFPGRRTGHVQIVDLANTE----RAPLEV 181
            .|::|...|::|..|:|..||.|||.|||...|.||.|||.:.|.:|:||||:|:    .||..:
  Rat   125 YVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTI 189

  Fly   182 IAHEAGISCIALNLQGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVV 246
            .||::.::|::||..||.:|:|.:||||||:|||:|.:|:.|||||::.|.::||||:|.|:.:.
  Rat   190 NAHQSDVACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLC 254

  Fly   247 VASDHGTIHVFNLEDNK-PRESSL-------PIIPKYFSSQWSFVKFSIPQGPRCVCAFGADP-- 301
            .:||.||:|:|.|:|.: .|.|:|       |:|.:|..||||...|::|....|:||||.:.
  Rat   255 ASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSK 319

  Fly   302 --NSVVAICADGHYYKFLFNNKGECSRDICTQFLELQDDE 339
              |||:|||.||.::|::|...|.|:|:....:|::.||:
  Rat   320 NVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDD 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	15/33 (45%)
		WD40	141..>265	CDD:421866	62/128 (48%)
		WD40 repeat	145..180	CDD:293791	19/38 (50%)
		WD40 repeat	188..225	CDD:293791	19/36 (53%)
		WD40 repeat	233..273	CDD:293791	18/47 (38%)
Wdr45	XP_006256772.1	WD40	<188..>275	CDD:421866	40/86 (47%)
Wdr45	XP_006256772.1	WD40 repeat	197..233	CDD:293791	19/35 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D454738at33208
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830