DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11975 and WIPI2

DIOPT Version :10

Sequence 1:NP_649853.1 Gene:CG11975 / 41074 FlyBaseID:FBgn0037648 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_056425.1 Gene:WIPI2 / 26100 HGNCID:32225 Length:454 Species:Homo sapiens


Alignment Length:376 Identity:109/376 - (28%)
Similarity:177/376 - (47%) Gaps:59/376 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNLTEQN-PYGNG-LLYAAFNQD----QGC--------------FACATDTGFRVYNCDPLKEKE 45
            |||..|: ..|.| ||:|.||||    :|.              .|..:.:|::.::...:.:.|
Human     1 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLE 65

  Fly    46 RQY--FPEGGLSHVEMLFRCNYLALVGGGIRPLYPPNKVIVWDDLKKSPAISLDFNQPVRAVRLR 108
            :.|  .....:..||.||..:.:|:|.     |..|.|:.|....|.:...:..::..:.||:|.
Human    66 QIYECTDTEDVCIVERLFSSSLVAIVS-----LKAPRKLKVCHFKKGTEICNYSYSNTILAVKLN 125

  Fly   109 RDRIVVVLEGVIKVFTFTQQPQQLH-VFETSSNPNGLCVLCPHSNKSLLAFPGRRT-GHVQIVDL 171
            |.|::|.||..:.:... :..:.|| :.||..||.|||.|..:::...||:||..| |.||:.|.
Human   126 RQRLIVCLEESLYIHNI-RDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDT 189

  Fly   172 ANTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFC- 235
            .|. ||...:.||::.::.:|.:..||:||||.||||:||:|....|:|:.|.|||.......| 
Human   190 INL-RAANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICS 253

  Fly   236 INFNHQSTMVVVASDHGTIHVFNLE--DNKPRE-----------------SSLPI-IPKYFSSQW 280
            :.|:.....:..:|:..|:|:|.||  ..||.|                 |.||. :.:.|:...
Human   254 LAFSMDGMFLSASSNTETVHIFKLETVKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGR 318

  Fly   281 SFVKFSIP-QGPRCVCAFGA---DPNSVVAICADGHYYKFLFNNK--GECS 325
            :|....:| .|.:.:|:...   .|..:|. .|||:.|.:..:.:  |||:
Human   319 AFATVRLPFCGHKNICSLATIQKIPRLLVG-AADGYLYMYNLDPQEGGECA 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11975NP_649853.1 WD40 <70..>265 CDD:441893 66/199 (33%)
WD40 repeat 102..136 CDD:293791 10/34 (29%)
WD40 repeat 145..180 CDD:293791 14/35 (40%)
WD40 repeat 188..225 CDD:293791 17/36 (47%)
WD40 repeat 233..273 CDD:293791 14/60 (23%)
WIPI2NP_056425.1 WD 1. /evidence=ECO:0000255 15..60 10/44 (23%)
WD 2. /evidence=ECO:0000255 67..104 11/41 (27%)
WD 3. /evidence=ECO:0000255 110..142 8/31 (26%)
WD40 repeat 120..156 CDD:293791 12/36 (33%)
WD40 <136..360 CDD:441893 69/226 (31%)
WD 4. /evidence=ECO:0000255 149..189 17/39 (44%)
WD40 repeat 161..200 CDD:293791 15/39 (38%)
WD 5. /evidence=ECO:0000255 193..232 18/38 (47%)
WD40 repeat 206..246 CDD:293791 20/39 (51%)
WD 6. /evidence=ECO:0000255 238..277 10/38 (26%)
L/FRRG motif. /evidence=ECO:0000303|PubMed:24954904 241..244 1/2 (50%)
WD40 repeat 251..284 CDD:293791 8/32 (25%)
WD40 repeat 292..327 CDD:293791 5/34 (15%)
WD 7. /evidence=ECO:0000255 320..359 10/39 (26%)

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