DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and SPAC458.06

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_594700.1	Gene:	SPAC458.06 / 2543338	PomBaseID:	SPAC458.06	Length:	364	Species:	Schizosaccharomyces pombe

Alignment Length:	247	Identity:	88/247 - (35%)
Similarity:	144/247 - (58%)	Gaps:	9/247 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSHVEMLFRCNYLALVGGGIRPLYPPNK 81
            :.|||..|.:.|.|||::::..:|||.:.::.|.:||||.|:||||.|.|.|||||..|.|.|||
pombe     8 SLNQDASCMSVALDTGYKIFQINPLKLRAQRQFNDGGLSIVKMLFRSNVLLLVGGGGNPKYAPNK 72

  Fly    82 VIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPNGLCV 146
            :|||||:|:.|...|:.|..::.:......:.:.....:.::.|....:.....:| .||.|||.
pombe    73 LIVWDDVKERPVKELELNFEIKGICFDGKLLAIATASKLFLYQFGNNLKLQRCLDT-QNPKGLCA 136

  Fly   147 LCPHSNKSLLAFPGRRTGHVQIV----DLANTERAPLEVIAHEAGISCIALNLQGTRLATAGEKG 207
            :.....|:.:.||.|:.|.:||:    |..||...|    ||::.|||:.::..|:::|::...|
pombe   137 MVTTVEKTAIVFPSRKVGQLQILFLFKDHMNTSIVP----AHDSEISCLGISKTGSKIASSSTNG 197

  Fly   208 TLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNL 259
            |||||:::|:|:|:.|.|||..|..:..:.|:....::..||...|:|:|:|
pombe   198 TLIRIWNSETGEKICEFRRGYQHTAVCQLAFSPDELLLACASKKETLHIFSL 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	1/33 (3%)
		WD40	141..>265	CDD:421866	43/123 (35%)
		WD40 repeat	145..180	CDD:293791	12/38 (32%)
		WD40 repeat	188..225	CDD:293791	15/36 (42%)
		WD40 repeat	233..273	CDD:293791	7/27 (26%)
SPAC458.06	NP_594700.1	WD40	2..>261	CDD:225201	88/247 (36%)
		WD40	<58..204	CDD:295369	50/150 (33%)
		WD40 repeat	93..127	CDD:293791	1/33 (3%)
		WD40	<172..249	CDD:295369	28/80 (35%)
		WD40 repeat	179..220	CDD:293791	17/40 (43%)
		WD40 repeat	223..260	CDD:293791	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	160	1.000	Domainoid score	I994
eggNOG	1	0.900	-	-		E1_KOG2111
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I1157
OMA	1	1.010	-	-		QHG54442
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	1	1.000	-	-		oto102147
orthoMCL	1	0.900	-	-		OOG6_102082
Panther	1	1.100	-	-	LDO	PTHR11227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	1	1.000	-	-		X947
TreeFam	1	0.960	-	-
	13	12.860