DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and mug179

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_593843.1	Gene:	mug179 / 2543297	PomBaseID:	SPAC823.16c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	350	Identity:	97/350 - (27%)
Similarity:	161/350 - (46%)	Gaps:	65/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLYAAFNQDQGCFACATDTGFRVYNCDPLK---EKERQYFPEGGLSHVEMLFRCNYLALVGGGIR 74
            :||.::|||:|..:..::.|::||..:|..   .|:     ..|.|..|||:..:.||.|  .|.
pombe     5 ILYCSWNQDRGFLSIGSENGYQVYRSNPFTLCFSKK-----ANGASICEMLYESSLLAFV--NIS 62

  Fly    75 PLYPPNKVIVWDDLKKSPAI-SLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETS 138
            |  ...:::...|:|:...: .:.:..||.:||...:|:||:::|.|.|:..    :.:.:..|.
pombe    63 P--ESTRLLKLVDIKRDIVLCRIFYPSPVLSVRFTWNRLVVLIKGSIYVYNL----KNMELINTL 121

  Fly   139 SNPNG-LCVLCPHSNKSLLAF-----PGRRTGHVQIVDLANTERA-PLEVI-AHEAGISCIALNL 195
            :...| :.....|.|  .:|:     ||.       :.||:.:.| |:.:| .|.:.:..:..:.
pombe   122 NTSKGNVIAFAVHEN--YVAYNSPTNPGD-------IYLASLDTAIPVTLIHCHSSAVQVVDFHP 177

  Fly   196 QGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNLE 260
            :|..:|||..|||:||:..|..|:.|:|||||...|:|..|:|:.....:..||::||||||.:.
pombe   178 RGHLIATASAKGTVIRVITTSDGELVTELRRGYIPASIVSISFHPVEPFLACASENGTIHVFKIS 242

  Fly   261 DNKPRESSLPIIPKYFSSQWS----------------FVKFSIPQGPRCVCAF-------GADPN 302
            ......:|.|......||.||                |....||:     .:|       .:.|:
pombe   243 KQPSDPNSSPTSSVTVSSSWSKYLTSNVAKVWDTRKEFATAKIPE-----ASFYGKIIFSSSGPH 302

  Fly   303 SVVAICADGHYYKFLFN--NKGECS 325
            ..|| ...||||:|..|  |.|.|:
pombe   303 IQVA-SYSGHYYRFAVNLKNGGNCA 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	9/33 (27%)
		WD40	141..>265	CDD:421866	41/131 (31%)
		WD40 repeat	145..180	CDD:293791	9/40 (23%)
		WD40 repeat	188..225	CDD:293791	13/36 (36%)
		WD40 repeat	233..273	CDD:293791	13/39 (33%)
mug179	NP_593843.1	WD40 repeat	8..43	CDD:293791	9/39 (23%)
		WD40 repeat	47..86	CDD:293791	10/42 (24%)
		WD40	<64..>315	CDD:225201	71/269 (26%)
		WD40	<87..240	CDD:295369	51/165 (31%)
		WD40 repeat	89..123	CDD:293791	10/37 (27%)
		WD40 repeat	127..165	CDD:293791	10/46 (22%)
		WD40 repeat	170..208	CDD:293791	14/37 (38%)
		WD40 repeat	216..246	CDD:293791	10/29 (34%)
		WD40 repeat	253..284	CDD:293791	5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.880