DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and atg18

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_594055.1	Gene:	atg18 / 2542180	PomBaseID:	SPAC589.07c	Length:	373	Species:	Schizosaccharomyces pombe

Alignment Length:	356	Identity:	113/356 - (31%)
Similarity:	172/356 - (48%)	Gaps:	72/356 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TDTGFRVYNCDPLKEKERQYFPEGGLSHVEMLFRCNYLALV---GGGIRPLYPPNKVIVWDDLKK 90
            |..|:::|||||..:...:.  :|..|.|||||..:.:|||   .|..|.|    |:|   :.||
pombe    19 TFDGYKIYNCDPFGKCFHKI--QGATSIVEMLFSTSLVALVEKDDGNNRKL----KLI---NTKK 74

  Fly    91 SPAI-SLDFNQPVRAVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPNGLCVLCPHSNKS 154
            |..| .|.|..|:.||:|.|.|::.|||..|.|:..:.. ..||..||:||...:|.|.|:|...
pombe    75 STTICELTFPTPLLAVKLNRKRLLAVLEEQIYVYDISNM-LLLHTIETTSNVFAVCALSPNSENC 138

  Fly   155 LLAFPGRR--------------------TGHVQIVDLANTERAPLEVIAHEAGISCIALNLQGTR 199
            .||:|..|                    :|.|.:.|:.|.::. .::.||:..::|:|.|..||.
pombe   139 YLAYPDSRDHEPRTEGESSSPNVSNSAVSGQVILWDVINCKQI-TKIEAHKDSLACLAFNSDGTM 202

  Fly   200 LATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQSTMVVVASDHGTIHVFNLED--- 261
            ||||.:.|.:||:|...||:::.:.||||..|.|:.|.|:..|:::.|.|...|:|:|.|::
pombe   203 LATASDNGRIIRVFAIPSGQRLYQFRRGSLPAQIYSIAFHPDSSLLTVTSSTQTVHIFRLKEVYS 267

  Fly   262 NKPRESSLP-----------------------IIPKYFSS----QWSFVKFSIPQGPR--CVCAF 297
            |..|:..||                       .:|:..|.    :..|....|| |.:  .:.||
pombe   268 NLERQGLLPSSPPPKESLLRRSSRSLIGTVGGYLPQSVSGMLDPERDFAYAHIP-GDKVTSIAAF 331

  Fly   298 GADPNSVVAICA-DGHYYKFLFNNK--GECS 325
            |.| |::|.:.. ||:.|.|..|.:  |||:
pombe   332 GPD-NTIVNVATYDGNLYSFRVNLRTGGECA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	12/33 (36%)
		WD40	141..>265	CDD:421866	45/146 (31%)
		WD40 repeat	145..180	CDD:293791	12/54 (22%)
		WD40 repeat	188..225	CDD:293791	15/36 (42%)
		WD40 repeat	233..273	CDD:293791	14/65 (22%)
atg18	NP_594055.1	WD40	<10..262	CDD:225201	88/253 (35%)
		WD40 repeat	46..84	CDD:293791	17/44 (39%)
		WD40	104..>264	CDD:295369	52/161 (32%)
		WD40 repeat	127..186	CDD:293791	12/59 (20%)
		WD40 repeat	191..229	CDD:293791	15/37 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950