DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and epg-6

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_871659.1	Gene:	epg-6 / 189705	WormBaseID:	WBGene00012641	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	104/368 - (28%)
Similarity:	179/368 - (48%)	Gaps:	43/368 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLTEQNPYGNGLLYAAFNQDQGCFACATDTGFRVYNCDPL----------KEKERQYFPEGGLSH 56
            |.||:.   ..|.:|:...|...||.|...||::|..:||          |....:...:.|.|.
Worm    28 NSTEEM---TTLNHASVTLDHSAFAIADKDGFKMYQLNPLHFRMYKDYVIKVGPVRLVKQDGNSR 89

  Fly    57 VEMLFRCNYLALVGGGIRPLYPPNKVIVWDDLKKSPAISLDFNQ---PVRAVRLRRDRIVVVLEG 118
                 |..|::.:.||   .:..|.::::|..:......:....   |:..:.:..:|:|.:...
Worm    90 -----RIIYVSALAGG---RFAQNNLMIFDVARNEEYFEITTPSRYGPITNIHVSPNRLVALNPN 146

  Fly   119 VIKVFTFTQQPQQLHVFETSSNPNGLCVLC--PHSNKSLLAFPGRRTGHVQIVDL----ANTERA 177
            .:.|:|:....:|:...:..|||.|:..:.  |.:....||:||.:||.|||:.|    |...::
Worm   147 RMFVWTYPDDIKQIRSEDIRSNPKGISAMSYDPTTAACYLAYPGFKTGSVQIMHLNALTARESKS 211

  Fly   178 PLEVIAHEAGISCIALNLQGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFCINFNHQS 242
            |:.:.||...|:.:|||.|||.:||...|||:||:||..:...:.|||||:..|::.|:.|:..|
Worm   212 PIVIEAHLTDIAQVALNCQGTLVATGSTKGTVIRVFDARTKGPLYELRRGTVQAHLQCMAFSPCS 276

  Fly   243 TMVVVASDHGTIHVFNLEDNKPRESSLPIIPKYFSSQWSFVKFSIPQGPRCVCAFGADP------ 301
            :.:.||||.||:|:|.:.|.:|::....:.....||  |.||..:.: |.....||..|
Worm   277 SYLAVASDKGTLHMFGIRDAEPQKKKNVLERSRGSS--SIVKIQLDR-PVMAIGFGKIPETPKNL 338

  Fly   302 NSVVAICADGHYYK--FLFNNKGECSRDICT--QFLELQDDET 340
            .|::|||||..|::  |..:|.|..:....:  :.:|:.:|.:
Worm   339 QSIIAICADATYWRHEFYKDNTGNFTSHFGSYDELIEVANDSS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	5/33 (15%)
		WD40	141..>265	CDD:421866	51/129 (40%)
		WD40 repeat	145..180	CDD:293791	13/40 (33%)
		WD40 repeat	188..225	CDD:293791	17/36 (47%)
		WD40 repeat	233..273	CDD:293791	13/39 (33%)
epg-6	NP_871659.1	WD40	9..>320	CDD:225201	88/304 (29%)
		WD40 repeat	80..124	CDD:293791	8/51 (16%)
		WD40 repeat	129..170	CDD:293791	8/40 (20%)
		WD40 repeat	173..216	CDD:293791	13/42 (31%)
		WD40 repeat	222..259	CDD:293791	17/36 (47%)
		WD40 repeat	267..306	CDD:293791	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I3173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I3172
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	1	1.010	-	-		D454738at33208
OrthoFinder	1	1.000	-	-		FOG0001347
OrthoInspector	1	1.000	-	-		oto20605
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	1	1.000	-	-		X947
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010