DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11975 and atg-18

DIOPT Version :9

Sequence 1:	NP_001262394.1	Gene:	CG11975 / 41074	FlyBaseID:	FBgn0037648	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_741576.1	Gene:	atg-18 / 179246	WormBaseID:	WBGene00018294	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	97/357 - (27%)
Similarity:	155/357 - (43%)	Gaps:	46/357 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEQNPYGNGLLYAAFNQDQGCFACATDTGFRVYNCDPLKEKERQYFPEGGLSH--------VEML 60
            :|:||  :.:.|..||||..........|:..|....:.|.....:....|:|        :|.|
Worm     6 SEENP--DSINYIGFNQDSKVICVGHKDGYMFYKTADILENNTLTYEGENLTHLGLNNCLIIERL 68

  Fly    61 FRCNYLALVGGGIRPLYPPNKVIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVLEGVIKVFTF 125
            |....:.::.     ...|..:.|:....::......||:.|..|||.||||||.||..|.::..
Worm    69 FSSALMVVIS-----QKDPRVLHVYHFTSRNIICDHRFNKSVLTVRLNRDRIVVCLEDCIYIYNL 128

  Fly   126 TQQPQQLHVFETSSNPNGLCVLCPHSNKSLLAFPGRR-TGHVQIVDLANTERAPLEVIAHEAGIS 189
            .......::.:|.:|..|:..|..:...:|:|:||.. ||.|.:.|..|..... ...|||..|:
Worm   129 KDMKMMHNIMDTPTNKLGVLDLTSNPGNALIAYPGSTDTGSVHLFDAINLSSVS-TFNAHEGTIA 192

  Fly   190 CIALNLQGTRLATAGEKGTLIRIFDTESGKKVSELRRG-SNHANIFCINFNHQSTMVVVASDHGT 253
            |:..|.:|..:|||..|||:||::...:|.::.|.||| :...||:.:.|:..|..:..:|:..|
Worm   193 CLKFNQEGNMIATASTKGTVIRVYSVPNGHRLFEFRRGVTRCVNIYSLCFSSDSKYLTSSSNTET 257

  Fly   254 IHVFNLE-----DNKPRESS-----LPIIPKYFS---------------SQWSFVKFSIPQGPRC 293
            :|||.||     ||||..|:     ...|.|.||               ::.||....:|...|.
Worm   258 VHVFKLEKTEGVDNKPEASTEGGGWFDAINKTFSAYMPSQVLQVGELMTTERSFATAKLPGAARS 322

  Fly   294 -VCAFGADPNS--VVAICADGHYYKFLFNNKG 322
             ..:..:..|.  |:|..:||..|.:..:.:|
Worm   323 NQVSLVSHKNQQYVMAATSDGFVYAYRLDPEG 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11975	NP_001262394.1	WD40 repeat	102..136	CDD:293791	13/33 (39%)
		WD40	141..>265	CDD:421866	45/130 (35%)
		WD40 repeat	145..180	CDD:293791	10/35 (29%)
		WD40 repeat	188..225	CDD:293791	14/36 (39%)
		WD40 repeat	233..273	CDD:293791	15/49 (31%)
atg-18	NP_741576.1	WD40	<93..>365	CDD:225201	79/263 (30%)
		WD40 repeat	96..142	CDD:293791	16/45 (36%)
		WD40 repeat	148..186	CDD:293791	10/38 (26%)
		WD40 repeat	191..228	CDD:293791	14/36 (39%)
		WD40 repeat	238..278	CDD:293791	14/39 (36%)
		WD40 repeat	325..364	CDD:293791	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54442
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R106
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950