DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(var)3-9 and ZBTB25

DIOPT Version :9

Sequence 1:	NP_649852.2	Gene:	E(var)3-9 / 41073	FlyBaseID:	FBgn0260243	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_016877119.1	Gene:	ZBTB25 / 7597	HGNCID:	13112	Length:	560	Species:	Homo sapiens

Alignment Length:	372	Identity:	81/372 - (21%)
Similarity:	127/372 - (34%)	Gaps:	117/372 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 GFICSSKETL-----KEHKQA------------VHVRTKC-------------------TYCGKT 343
            ||:|.....:     |.|:..            :|..::|                   .|.||.
Human   146 GFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYTGKG 210

  Fly   344 VKNATLHAHLKKHLEEGEAE-LAQQLKKLEQL--PVNLQSQHLSSLESSVAEVTTASEGSNIPGE 405
            .|....|:.|::.:....|: |:....::.|:  |..:||.:|..::.|..:.|...:|..:...
Human   211 PKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYGIQISTTQKTVVKQGLEVKEA 275

  Fly   406 STVPEDSNVTENSSVPSIETS-------NHADIQ--CP--------MGPPAN--GEVPDVADV-- 449
            .:....:........|.::.|       ..||.|  ||        ..||.:  .|..|...|
Human   276 PSSNSGNRAAVQGDHPQLQLSLAIGLDDGTADQQRACPATQALEEHQKPPVSIKQERCDPESVIS 340

  Fly   450 ---ASPSTEP-----TESVTK---CSYCSDTFEKAQQLQAHVLATHTQTRKRRRSSDNQSLVRKT 503
               .|||:|.     ||:..|   |.||.:.|:....|:.| |.||                  .
Human   341 QSHPSPSSEVTGPTFTENSVKIHLCHYCGERFDSRSNLRQH-LHTH------------------V 386

  Fly   504 TQEIPTSPIAKITKKQTI-------ESKER---------VVLESSSQLDSTAQ------QESRTS 546
            :..:|....|.|.:...:       |:.|.         :|.|:..|.|.|.:      |.|:.|
Human   387 SGSLPFGVPASILESNDLGEVHPLNENSEALECRRLSSFIVKENEQQPDHTNRGTTEPLQISQVS 451

  Fly   547 ATSNDSSPVQ-----QVPEKAYISCYICGRSFDLKIKLNRHLKQHKG 588
            ..|.|:.||:     ....|..:||.|||..|..|.:|..|:..|||
Human   452 LISKDTEPVELNCNFSFSRKRKMSCTICGHKFPRKSQLLEHMYTHKG 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:285071
		zf-C2H2_2	253..>334	CDD:289522	6/35 (17%)
		C2H2 Zn finger	253..274	CDD:275368
		C2H2 Zn finger	281..303	CDD:275368
		PHA00732	310..>358	CDD:177300	13/78 (17%)
		C2H2 Zn finger	311..332	CDD:275368	5/33 (15%)
		C2H2 Zn finger	337..356	CDD:275368	7/37 (19%)
ZBTB25	XP_016877119.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000