Protein Alignment E(var)3-9 and ZFX

DIOPT Version :10

• Sequence 1: NP_649852.2
• Gene: E(var)3-9 / 41073
• FlyBaseID: FBgn0260243
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001317256.1
• Gene: ZFX / 7543
• HGNCID: 12869
• Length: 844
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 126/652 - (19%)
• Similarity: 213/652 - (32%)
• Gaps: 247/652 - (37%)

  Fly    42 SDDAAVADMAEILEQMNDWN-IKVAREDGRPQYMCIACIAEFHRLIKFKRSCVE----TQEQFGE 101
            |::..|||.|.  |.:.|.| |.|.::|..                  |.:|.:    :.:..|:
Human   216 SEEVLVADCAS--EAVIDANGIPVDQQDDD------------------KGNCEDYLMISLDDAGK 260

  Fly   102 LEYQREHNGIVIKREIEPEEEKFCGF------IYLDTDEEDNSDEDGSRRVCAVFDIPHVPIKEE 160
            :|:... :|:.:..|.|.:..|..|.      :|:...:....|..|:      .||.....:.:
Human   261 IEHDGS-SGMTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGT------VDIVESEPEND 318

  Fly   161 HMARVPLQNSDKFQPPEPKNFASPVDSRFDMIDNDALTSGMLGPSIEDLS-GTVDD--------G 216
            |...:..|||....|.|...:.:..||:               |..|||: ..:.|        |
Human   319 HGVELLDQNSSIRVPREKMVYMTVNDSQ---------------PEDEDLNVAEIADEVYMEVIVG 368

  Fly   217 TED------------EEEEEEEIVRF-------TYDDDND--------AAAPLPPPLYSPVVCCK 254
            .||            ::.::.||..|       .|.:::|        |:|.|
Human   369 EEDAAAAAAAAAVHEQQMDDNEIKTFMPIAWAAAYGNNSDGIENRNGTASALL------------ 421

  Fly   255 LCFYESPDQDAHMEHMRRT-----------------------HLLKDWECHICGKKFTNAQESR- 295
                 ..|:.|.:..:.:.                       |.|..:.|.||||||    :||
Human   422 -----HIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKF----KSRG 477

  Fly   296 -IKFHIKYHK---LQRHVKCPVCGFICSSKETLKEHKQAVHVRTK------CTYCGKTVKNA-TL 349
             :|.|:|.|.   .::..:|..|.:..:.|.:|..|.::..:.:|      |..|||...:| .|
Human   478 FLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGAL 542

  Fly   350 HAHLKKHLEEG----------EAELAQQLKKLEQLPVNLQSQHLSSLESSVAEVTTASEGSNIPG 404
            ..|...|.|:|          |.|.|:|         .|.::||.::.|           .|.|
Human   543 FTHKMVHKEKGANKMHKCKFCEYETAEQ---------GLLNRHLLAVHS-----------KNFP- 586

  Fly   405 ESTVPEDSNVTENSSVPSIETSNHADIQCPMG--PPA---------NGEVPDVADVASPSTEPTE 458
                                   |..::|..|  .|:         .||.|
Human   587 -----------------------HICVECGKGFRHPSELKKHMRIHTGEKP-------------- 614

  Fly   459 SVTKCSYCSDTFEKAQQLQAHVLATHTQTRKRRRSSDNQSLVRKTTQEIP-TSPIAKITKKQTIE 522
              .:|.||......:..|:.||...|                   ::|:| ...|..:|...|.|
Human   615 --YQCQYCEYRSADSSNLKTHVKTKH-------------------SKEMPFKCDICLLTFSDTKE 658

  Fly   523 SKERVVLESSSQLDSTAQQESRTSATSNDSSPVQQVPEKAY-ISCYICGRSFDLKIKLNRHLKQH 586
            .::..::...|:.......:.::|.:|:....:..|..|.| ..|.:|.:.|....:|.:|:..|
Human   659 VQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKGFHRPSELKKHVAAH 723

  Fly   587 KG 588
            ||
Human   724 KG 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:462262	14/64 (22%)
		zf-C2H2_2	253..>334	CDD:463690	22/108 (20%)
		C2H2 Zn finger	253..274	CDD:275368	2/43 (5%)
		C2H2 Zn finger	281..303	CDD:275368	12/23 (52%)
		PHA00732	310..>358	CDD:177300	14/54 (26%)
		C2H2 Zn finger	311..332	CDD:275368	5/20 (25%)
		C2H2 Zn finger	337..356	CDD:275368	7/19 (37%)
ZFX	NP_001317256.1	Zfx_Zfy_act	109..449	CDD:461400	51/291 (18%)
		ROS_MUCR	<416..>496	CDD:473244	20/100 (20%)
		C2H2 Zn finger	466..486	CDD:275368	12/23 (52%)
		C2H2 Zn finger	497..521	CDD:275368	5/23 (22%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		COG5048	582..>719	CDD:227381	33/206 (16%)
		C2H2 Zn finger	589..609	CDD:275368	3/19 (16%)
		C2H2 Zn finger	617..636	CDD:275368	6/18 (33%)
		C2H2 Zn finger	674..695	CDD:275368	2/20 (10%)
		C2H2 Zn finger	703..723	CDD:275368	5/19 (26%)
		zf-C2H2	758..780	CDD:395048
		C2H2 Zn finger	760..780	CDD:275368
		zf-H2C2_2	772..796	CDD:463886
		C2H2 Zn finger	788..809	CDD:275368
		C2H2 Zn finger	817..837	CDD:275368