DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(var)3-9 and ZFP37

DIOPT Version :9

Sequence 1:	NP_649852.2	Gene:	E(var)3-9 / 41073	FlyBaseID:	FBgn0260243	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001269444.1	Gene:	ZFP37 / 7539	HGNCID:	12863	Length:	645	Species:	Homo sapiens

Alignment Length:	551	Identity:	109/551 - (19%)
Similarity:	183/551 - (33%)	Gaps:	148/551 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RLIKFKRSCVETQEQFGELEYQREHNGIVIKREIEPEEEKFCGFIYLDTDEEDNSDEDGSRRVCA 148
            ||:||: ||.:..:|..:|.   :|:...:||:.:..:|....|.:..:|......:.|.:
Human   188 RLLKFE-SCGKILKQNLDLP---DHSRNCVKRKSDAAKEHKKSFNHSLSDTRKGKKQTGKK---- 244

  Fly   149 VFDIPHVPIKEEHMARVPLQNSDKFQPPEPKNFASPVDSRFDMIDNDALTSGMLGPSIEDLSGTV 213
                 |..:...       .:|||......|:......|. ..|..|.:.:|    ...:.|.::
Human   245 -----HEKLSSH-------SSSDKCNKTGKKHDKLCCHSS-SHIKQDKIQTG----EKHEKSPSL 292

  Fly   214 DDGTEDEEEEEEEIVRFTYDDDNDAAAPLPPPLYSPVVC-----CKLCFYESPDQDAHMEHMRRT 273
            ...|:.|:                           |..|     |..|......:...::|.|..
Human   293 SSSTKHEK---------------------------PQACVKPYECNQCGKVLSHKQGLIDHQRVH 330

  Fly   274 HLLKDWECHICGKKFTNAQESRIKFHIKYHKLQRHVKCPVCGFICSSKETLKEHKQAVHVRTK-- 336
            ...|.:||:.||..|  :|:|.:..|.:.|..::..:|..||.....|..|.:|.: :|...|
Human   331 TGEKPYECNECGIAF--SQKSHLVVHQRTHTGEKPYECIQCGKAHGHKHALTDHLR-IHTGEKPY 392

  Fly   337 -CTYCGKTVKNAT-LHAHLKKHLEEGEAELAQQLKKLEQLPVNLQSQHLSSLESSVAEVTTASEG 399
             |..||||.:::: |..|::.|..|...|..:..|..         ::.|||...|...|
Human   393 ECAECGKTFRHSSNLIQHVRSHTGEKPYECKECGKSF---------RYNSSLTEHVRTHT----- 443

  Fly   400 SNIPGESTVPEDSNVTENSSVPSIETSNHADIQCPMGPPANGEVPDVADVASPSTEPTESVTKCS 464
                ||  :|.:.|....:...|...:.|..|.       .||.|                .:|:
Human   444 ----GE--IPYECNECGKAFKYSSSLTKHMRIH-------TGEKP----------------FECN 479

  Fly   465 YCSDTFEKAQQLQAHVLATHTQTRKRR---------RSSDNQSLVRKTTQEIP---------TSP 511
            .|...|.|...|..| ..|||:.:..:         .||.....:|..|.|.|         ...
Human   480 ECGKAFSKKSHLIIH-QRTHTKEKPYKCNECGKAFGHSSSLTYHMRTHTGESPFECNQCGKGFKQ 543

  Fly   512 IAKITKKQTIES----------------KERVVLESSSQLDSTAQQESRTSATSNDSSPV----- 555
            |..:|:.|.:.:                |..:::...:.......:.:......|..|.:
Human   544 IEGLTQHQRVHTGEKPYECNECGKAFSQKSHLIVHQRTHTGEKPYECNECEKAFNAKSQLVIHQR 608

  Fly   556 QQVPEKAYISCYICGRSFDLKIKLNRHLKQH 586
            ....||.| .|..||::|.....|.:|:|.|
Human   609 SHTGEKPY-ECNECGKTFKQNASLTKHVKTH 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:285071	7/17 (41%)
		zf-C2H2_2	253..>334	CDD:289522	21/80 (26%)
		C2H2 Zn finger	253..274	CDD:275368	4/20 (20%)
		C2H2 Zn finger	281..303	CDD:275368	7/21 (33%)
		PHA00732	310..>358	CDD:177300	16/51 (31%)
		C2H2 Zn finger	311..332	CDD:275368	6/20 (30%)
		C2H2 Zn finger	337..356	CDD:275368	7/19 (37%)
ZFP37	NP_001269444.1	KRAB	47..106	CDD:214630
		KRAB	47..86	CDD:279668
		COG5048	288..>633	CDD:227381	82/419 (20%)
		C2H2 Zn finger	310..330	CDD:275368	4/19 (21%)
		C2H2 Zn finger	338..358	CDD:275368	7/21 (33%)
		zf-H2C2_2	350..372	CDD:290200	5/21 (24%)
		C2H2 Zn finger	366..386	CDD:275368	6/20 (30%)
		zf-H2C2_2	378..403	CDD:290200	9/25 (36%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		zf-H2C2_2	406..431	CDD:290200	6/33 (18%)
		C2H2 Zn finger	422..442	CDD:275368	5/28 (18%)
		zf-H2C2_2	434..459	CDD:290200	8/35 (23%)
		zf-C2H2	448..470	CDD:278523	3/21 (14%)
		C2H2 Zn finger	450..470	CDD:275368	3/19 (16%)
		zf-H2C2_2	462..486	CDD:290200	7/46 (15%)
		C2H2 Zn finger	478..498	CDD:275368	6/20 (30%)
		zf-H2C2_2	490..513	CDD:290200	5/23 (22%)
		C2H2 Zn finger	506..526	CDD:275368	3/19 (16%)
		zf-H2C2_2	518..543	CDD:290200	4/24 (17%)
		C2H2 Zn finger	534..554	CDD:275368	3/19 (16%)
		zf-H2C2_2	547..571	CDD:290200	2/23 (9%)
		C2H2 Zn finger	562..582	CDD:275368	1/19 (5%)
		zf-H2C2_2	574..598	CDD:290200	0/23 (0%)
		C2H2 Zn finger	590..610	CDD:275368	2/19 (11%)
		zf-H2C2_2	603..627	CDD:290200	7/24 (29%)
		C2H2 Zn finger	618..638	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000