DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(var)3-9 and IKZF5

DIOPT Version :9

Sequence 1:NP_649852.2 Gene:E(var)3-9 / 41073 FlyBaseID:FBgn0260243 Length:588 Species:Drosophila melanogaster
Sequence 2:NP_001258769.1 Gene:IKZF5 / 64376 HGNCID:14283 Length:419 Species:Homo sapiens


Alignment Length:384 Identity:70/384 - (18%)
Similarity:133/384 - (34%) Gaps:105/384 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 PEPKNFASPVDSRFDMIDNDALTSGMLGPSI------EDLSGTVDDGTEDEEEEEEEIVRFTYDD 234
            |||.:|.....   :.:........|:..|:      |.|.|...||  |:...:...|..:.|:
Human     6 PEPLDFVKDFQ---EYLTQQTHHVNMISGSVSGDKEAEALQGAGTDG--DQNGLDHPSVEVSLDE 65

  Fly   235 DNDAAAPLPPPLYSPVVCCKLCFYESPDQDAHMEHMRRTHLLKDWECHICGKKFTNAQESRIKFH 299
            ::..........:...:.|:.|.|.|......:||:|.....|...||:|  .|.:|.|..::.|
Human    66 NSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLC--PFASAYERHLEAH 128

  Fly   300 IKYHKLQRHVKCPVCGFICSSKETLKEHKQAVHVRTKCTYCGKTVKNATLHAHLKKH---LEEGE 361
            ::.|..::..||.:|.|.||.:..|..|::..|...       .:|........||.   |::..
Human   129 MRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMV-------PIKGTRSSLSSKKMWGVLQKKT 186

  Fly   362 AELAQQLKKL--------------------EQLPVNLQSQHLSSL------------------ES 388
            :.|....:.|                    .::| |:|:....|:                  ::
Human   187 SNLGYSRRALINLSPPSMVVQKPDYLNDFTHEIP-NIQTDSYESMAKTTPTGGLPRDPQELMVDN 250

  Fly   389 SVAEVTT-ASEGSNIPGE---------------------------------STVPEDSNVTENSS 419
            .:.:::| |.:.|::|.|                                 :::|:.|:.|....
Human   251 PLNQLSTLAGQLSSLPPENQNPASPDVVPCPDEKPFMIQQPSTQAVVSAVSASIPQSSSPTSPEP 315

  Fly   420 VPSIETSNHADIQCPMG-PPANGEVPDVADVASPST-------EPTESVTKCSYCSDTF 470
            .||....|::.:..|.. |.|:...|.:.: :.|||       :..:.:..|.:|...|
Human   316 RPSHSQRNYSPVAGPSSEPSAHTSTPSIGN-SQPSTPAPALPVQDPQLLHHCQHCDMYF 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(var)3-9NP_649852.2 zf-AD 18..102 CDD:285071
zf-C2H2_2 253..>334 CDD:289522 25/80 (31%)
C2H2 Zn finger 253..274 CDD:275368 7/20 (35%)
C2H2 Zn finger 281..303 CDD:275368 7/21 (33%)
PHA00732 310..>358 CDD:177300 12/50 (24%)
C2H2 Zn finger 311..332 CDD:275368 7/20 (35%)
C2H2 Zn finger 337..356 CDD:275368 2/18 (11%)
IKZF5NP_001258769.1 C2H2 Zn finger 84..104 CDD:275368 7/19 (37%)
zf-H2C2_2 96..121 CDD:404364 8/26 (31%)
C2H2 Zn finger 112..132 CDD:275368 7/21 (33%)
zf-H2C2_2 124..148 CDD:404364 6/23 (26%)
C2H2 Zn finger 140..158 CDD:275368 7/17 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..247 2/23 (9%)
PHA03269 251..>361 CDD:165527 18/110 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..356 16/94 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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