DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(var)3-9 and Ikzf5

DIOPT Version :9

Sequence 1:	NP_649852.2	Gene:	E(var)3-9 / 41073	FlyBaseID:	FBgn0260243	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001101025.1	Gene:	Ikzf5 / 309031	RGDID:	1310965	Length:	419	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	92/456 - (20%)
Similarity:	156/456 - (34%)	Gaps:	120/456 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PEPKNFASPVDSRFDMIDNDALTSGMLGPSI------EDLSGTVDDGTEDEEEEEEEIVRFTYDD 234
            |||.:|.....   :.:........|:..|:      |.|.|...||  |:...:...|..:.|:
  Rat     6 PEPLDFVKDFQ---EYLTQQTHHVNMISGSVSGDKEAETLQGAGTDG--DQNGLDHPSVEVSLDE 65

  Fly   235 DNDAAAPLPPPLYSPVVCCKLCFYESPDQDAHMEHMRRTHLLKDWECHICGKKFTNAQESRIKFH 299
            ::..........:...:.|:.|.|.|......:||:|.....|...||:|  .|.:|.|..::.|
  Rat    66 NSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLC--PFASAYERHLEAH 128

  Fly   300 IKYHKLQRHVKCPVCGFICSSKETLKEHKQAVHVRTKCTYCGKTVKNATLHAHLKKHLEEGEAEL 364
            ::.|..::..||.:|.|.||.:..|..|::                        :||
  Rat   129 MRSHTGEKPYKCELCSFRCSDRSNLSHHRR------------------------RKH-------- 161

  Fly   365 AQQLKKLEQLPVNLQSQHLSSLES-SVAEVTTASEG------SNIPGESTVPEDSNVTEN--SSV 420
                   :.:|:......|||.:. .|.:..|::.|      .|:...|.|.:..:...:  ..:
  Rat   162 -------KMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHEI 219

  Fly   421 PSIETSNHADIQ-------CPMGP-------PAN------GEV----PDVADVASPSTEPTESVT 461
            |:|:|.::..:.       .|..|       |.|      |::    |:..:.|||..:|
  Rat   220 PNIQTDSYETMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPDVDP----- 279

  Fly   462 KCSYCSDTFEK---AQQLQAHVLATHTQTRKRRRSSDNQSLVRKTTQEIPTSPIAKITKKQTIES 523
                |.|  ||   .||..|..:.:.......:.||             ||||..:.:..|...|
  Rat   280 ----CPD--EKPFMIQQPSAQAVVSAVSASIPQSSS-------------PTSPDPRPSHSQRNYS 325

  Fly   524 KERVVLESSSQLDSTAQQESRTSATSNDSSPVQQVP---EKAYISCYICGRSFDLKIKLNRHLKQ 585
            .   |...||  :.:|...:.:...|..|:|...:|   .:....|..|...|...|....|:..
  Rat   326 P---VAGPSS--EPSAHTSTPSIGNSQPSTPAPTLPVQDPQLLHHCQHCDMYFADNILYTIHMGC 385

  Fly   586 H 586
            |
  Rat   386 H 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:285071
		zf-C2H2_2	253..>334	CDD:289522	24/80 (30%)
		C2H2 Zn finger	253..274	CDD:275368	7/20 (35%)
		C2H2 Zn finger	281..303	CDD:275368	7/21 (33%)
		PHA00732	310..>358	CDD:177300	10/47 (21%)
		C2H2 Zn finger	311..332	CDD:275368	7/20 (35%)
		C2H2 Zn finger	337..356	CDD:275368	0/18 (0%)
Ikzf5	NP_001101025.1	C2H2 Zn finger	84..104	CDD:275368	7/19 (37%)
		zf-H2C2_2	96..121	CDD:404364	8/26 (31%)
		C2H2 Zn finger	112..132	CDD:275368	7/21 (33%)
		zf-H2C2_2	124..148	CDD:404364	6/23 (26%)
		C2H2 Zn finger	140..158	CDD:275368	7/17 (41%)
		PHA03269	251..>361	CDD:165527	31/138 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000