DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(var)3-9 and Zfp658

DIOPT Version :9

Sequence 1:	NP_649852.2	Gene:	E(var)3-9 / 41073	FlyBaseID:	FBgn0260243	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001008549.1	Gene:	Zfp658 / 210104	MGIID:	2652821	Length:	887	Species:	Mus musculus

Alignment Length:	559	Identity:	113/559 - (20%)
Similarity:	172/559 - (30%)	Gaps:	190/559 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 REHNGIVIKREIEPEEEKFCGFIYLDTDEEDNSDEDGSRRVCAVFDIPHVPIKEEHMARVPLQNS 170
            ::.||:|....:.|                    :|.|...|.:......|.|.....:||...
Mouse   216 KQLNGLVTSAHLLP--------------------QDSSNANCTILRETWNPCKGNQCRKVPTHK- 259

  Fly   171 DKFQPPEPKNFASPVDSRFDMIDNDALTSGMLGPSIEDLSGTVDDGTEDEEEEEEEIVRFTYDDD 235
                               .:.:.:|.:...|           |:|||..        :..||:.
Mouse   260 -------------------QLTEKEAHSREKL-----------DEGTECR--------KVFYDES 286

  Fly   236 NDAAAPLPPPLYSPVVC--CKLCF-----------------YESPD------QDAHMEHMRRTHL 275
            .............|.||  |...|                 ||.||      :.::::...|.|.
Mouse   287 AFCKHQAAHAGEGPFVCHKCGEAFLQKTEFASHQETHPEKPYECPDCGKSFSRTSNLQVHHRIHT 351

  Fly   276 -LKDWECHICGKKFTNAQESRIKFHIKYHKLQRHVKCPVCGFICSSKETLKEHKQAVHVRT---K 336
             .|.:||..|||.|.|.  |::|.|.:.|..:|...|||||.....|..|..| :.:|...   |
Mouse   352 GEKPYECRDCGKSFNNT--SQLKVHYRIHTGERPYVCPVCGKAFKQKSILSTH-ETIHTGEKPYK 413

  Fly   337 CTYCGKTVK-NATLHAHLKKHLEEGEAE---LAQQLKKLEQLPVNLQSQHLSSLESSVAEVTTAS 397
            ||.|||... .:.|..|.:.|::|...|   ..:..|:...|.|: |..|:.......:|.
Mouse   414 CTVCGKLFSCTSRLKVHYQIHMKEKPYECGDCGKAFKRKSSLTVH-QKIHIRQTHHECSEC---- 473

  Fly   398 EGSNIPGESTVPEDSNVTENSSVPSIETSNHADIQCPMGPPANGEVPDVADVASPSTEPTESVTK 462
             |.....:|                 |.|.|..:.  :|..::                     :
Mouse   474 -GKTFNQKS-----------------ELSTHQRLH--LGKNSH---------------------R 497

  Fly   463 CSYCSDTFEKAQQLQAHVLATHTQTRKRRRSSDNQSLVRKTTQEIPTSPIAKITK---------- 517
            ||.|..:|..|.||:.| ...||..:..:.....:|.....|..:... |.|:.|
Mouse   498 CSDCGKSFTYASQLKMH-RRVHTGEKPYKCRDCGKSFTYSFTLNVHRR-IHKVEKPHKCSICGKA 560

  Fly   518 ---KQTIESKER--------VVLESSS-----------QLDSTAQQE-----------SRTSATS 549
               |..:|..||        |..|...           |:..|..:.           .|:..||
Mouse   561 LASKYQLEEHERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTS 625

  Fly   550 NDSSPVQQVPEKAYISCYICGRSFDLKIKLNRHLKQHKG 588
            :..:   ...||.| :|:.||:||....:|..|.:.|.|
Mouse   626 HQQT---HTGEKPY-TCHYCGKSFSHTSQLTVHHRIHTG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:285071
		zf-C2H2_2	253..>334	CDD:289522	30/104 (29%)
		C2H2 Zn finger	253..274	CDD:275368	7/43 (16%)
		C2H2 Zn finger	281..303	CDD:275368	9/21 (43%)
		PHA00732	310..>358	CDD:177300	18/51 (35%)
		C2H2 Zn finger	311..332	CDD:275368	8/20 (40%)
		C2H2 Zn finger	337..356	CDD:275368	7/19 (37%)
Zfp658	NP_001008549.1	KRAB	23..80	CDD:214630
		C2H2 Zn finger	275..295	CDD:275368	5/27 (19%)
		COG5048	300..684	CDD:227381	94/416 (23%)
		C2H2 Zn finger	303..323	CDD:275368	3/19 (16%)
		C2H2 Zn finger	330..350	CDD:275368	3/19 (16%)
		C2H2 Zn finger	358..378	CDD:275368	9/21 (43%)
		C2H2 Zn finger	386..406	CDD:275368	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	4/20 (20%)
		C2H2 Zn finger	470..490	CDD:275368	6/41 (15%)
		COG5048	493..887	CDD:227381	38/195 (19%)
		C2H2 Zn finger	498..518	CDD:275368	8/20 (40%)
		C2H2 Zn finger	526..546	CDD:275368	2/20 (10%)
		C2H2 Zn finger	554..574	CDD:275368	4/19 (21%)
		C2H2 Zn finger	582..602	CDD:275368	2/19 (11%)
		C2H2 Zn finger	610..630	CDD:275368	3/22 (14%)
		C2H2 Zn finger	638..658	CDD:275368	7/19 (37%)
		C2H2 Zn finger	666..686	CDD:275368
		C2H2 Zn finger	694..714	CDD:275368
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	778..798	CDD:275368
		C2H2 Zn finger	806..826	CDD:275368
		C2H2 Zn finger	834..854	CDD:275368
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000