DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11970 and nfrkb

DIOPT Version :9

Sequence 1:	NP_001287243.1	Gene:	CG11970 / 41072	FlyBaseID:	FBgn0027503	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001229964.1	Gene:	nfrkb / 567709	ZFINID:	ZDB-GENE-030131-6419	Length:	1290	Species:	Danio rerio

Alignment Length:	1562	Identity:	416/1562 - (26%)
Similarity:	628/1562 - (40%)	Gaps:	418/1562 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SDELELAQ----------LTGRDIFRLPRGLCENAAIFHEFFSLETWQQ-LPHHLQARLQPMLPD 151
            :|.||.|.          :.|....|:|..|.|:..||....|..||.. |....:..|:.:||.
Zfish     9 TDPLESAMDQDGRVMEECMLGNCRVRVPEDLLEDPEIFFSVLSESTWTDVLTEAQRTHLRQLLPQ 73

  Fly   152 FSRLVSGQAQACAEQQRTLVQLFNGGLQRFGQSPLLQLQRQLEEGNLRPDVLQLRRSIQHSGRRE 216
            |..      :..|||...:..|||.....|| :||...|:...:|:..|:|::.|:....|.::.
Zfish    74 FPE------ENMAEQNSIIGDLFNNKNFLFG-NPLHIAQKLFRDGHFNPEVVKYRQLCAKSQKKR 131

  Fly   217 FRFQQAERLSLLAKELFMSREQLLQHAYTSAPPSDGAFGKNLPRPRSRKRKPPTLSIENKFCSQR 281
            ..:...:....|.|::.:||::||..|..|.|            ..:.||:.|..| ..:...||
Zfish   132 QIYSLQQYYHKLLKQILVSRKELLDLAVRSGP------------ELAVKRRYPAAS-HKEMLEQR 183

  Fly   282 AKKRYAQELLELIGSLEAKPGDISAEEEEEDEECRQLMDRLAKGPQEFELEETKAPEPAGPGRPS 346
            .::|..    .:|..::.:.||.:...:|:|                   ..:..|.|..|..|:
Zfish   184 VRRRVG----HIIKDVKTECGDSNVSSDEDD-------------------SSSWLPVPQSPSSPT 225

  Fly   347 NAADKKCIYNTFFKRRPGVDDDLVLRSMQAEKIPKLNDKNFRKYLRDYKRRKLEQPESPEFDTSE 411
                     .||..|   |...|..:.|:....|:|.:|..|..|..::.::..||:.|:..||:
Zfish   226 ---------PTFSLR---VLPSLSTQDMKTRDKPELGEKELRAMLHRHREKRKRQPDHPDLMTSD 278

  Fly   412 VRLRDICTRAQFVGSFKPGRKPKALMARLNPDPPALVPIGVTPTKNEFVDEEPMLLDEPQQLYGR 476
            :.|.||.:|...      |||....:..|           ..|.|.        :.:|.::...|
Zfish   279 LHLGDIMSRVNI------GRKGSVTVFDL-----------AIPKKK--------IKEEKRKKKMR 318

  Fly   477 RAPEDHPEEDLPHKEPPPMPKKVMPAPVVLPQPVPKLEPLNGPITNPKASPTTPNHSNNPITVSA 541
            ....:..|........|||...:...|...||.| |.||::.|.|:|.             ||..
Zfish   319 PIKMESEEVCDVQMSAPPMNPGLTDVPAAPPQSV-KEEPIDEPQTSPD-------------TVEE 369

  Fly   542 TAGHITGSPTREVQIRPPASPRPACFFSLLRDLFVSTPQHRL----TYGELQILLSSWREINSDA 602
            .|                     ..||.||.|:.      ||    |...::..:..|:  :|.|
Zfish   370 IA---------------------MSFFHLLEDIL------RLEGLATSSTMEEKVQQWQ--SSPA 405

  Fly   603 SIPIGEWPRFRPDWSKLLQSAINFLSGD----FSSVPADYVPYIEHKTQLGIYQWIGAGRDSDAR 663
            | .:..|....|.||:::..|:.||:|:    ..::|..::|::|.|.....::|||:.:|.|..
Zfish   406 S-TLNPWFSMAPCWSEVVVPALQFLAGESKAGVMALPTGFIPFVEFKEVSQQWKWIGSSQDGDKD 469

  Fly   664 LLSLCQFWL--------RTQREKQSQLSPVLISGVHLNSLVDASPTPPPRCPTTWTVRSATQAEI 720
            |.:|||.||        :.:.|:.::|:|                 |.||..|.:.||.:|..|.
Zfish   470 LSALCQLWLESKDHVIVKQEGEETAELTP-----------------PTPRVWTDYVVRPSTGEER 517

  Fly   721 LEFQSQERIRFEYPHRPFTYRLNGYESVVGPVKGIYTQGLPLNKARGHAVMVDDRPPFVTILTLV 785
            ..||.||:.|::.||:.||||::|:|||||||||::.:...|||||.|:::..|||.:||||:||
Zfish   518 HVFQEQEQQRYDQPHKAFTYRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLV 582

  Fly   786 RDATARLPNGEGTRSEISELLKCSQYISQQAADNVLQTIVSGALDRMHGGPDPCVKYDARRKIWI 850
            |||.||||||||||:||.||||.||:::.......:.|:|||||||:|...|||||||..||:||
Zfish   583 RDAAARLPNGEGTRAEICELLKDSQFLAPDVTSAQVNTVVSGALDRLHYEKDPCVKYDIGRKLWI 647

  Fly   851 YLHRNRSEAEFEKMHRHNQSLVKQK---QQQRKQLNRPKI----PDDRSGLAADHQQ-------- 900
            ||||:||:.|||::|:...:..|.|   ||:.|...:||.    |..::|:|...|.
Zfish   648 YLHRDRSQEEFERIHQAQAAAAKAKKALQQKPKPAPKPKAGGKEPGSKNGIAEAGQSTSNEGIAI 712

  Fly   901 -----EQVPA-------------LVPAVASPVPVSVQQPVVASLQMKKPLAVKCPPVPPLKYHVP 947
                 .|.|:             |.|..|:|..|:..:|:..:              |.:....|
Zfish   713 AATSLSQTPSTPTQSTPGTPKSPLPPTSATPTKVAAPEPIKTN--------------PSVLLVSP 763

  Fly   948 PGTPIGGTIISASSNINANQIPMQQIQKSLLKPVVVPNSAPSPVQRQLATGKSGTFAISKISPTR 1012
            |..|..||::|||.       |..|:.:.     ..|.||...|....|||......:....|:.
Zfish   764 PTMPQLGTLLSASQ-------PSPQVSQQ-----ASPQSATRVVAHSAATGSLPQVRVVTAQPSL 816

  Fly  1013 NTT------------------PILVSTPSGLQTVHVATTP--NQAGGS----------AS---PT 1044
            :|:                  |:.|:....: |..|.|.|  ||:.||          ||   |.
Zfish   817 HTSTAGQAATLVHQSPHHIRVPVTVAHGKNI-TQAVVTLPLRNQSAGSPIQVQASRGQASLTVPG 880

  Fly  1045 VAKKLTIKKP---VPNNKIGNFIIPLDQQQSGPQQ--QQPTQQGQ-HVKVQPIAGKPKALTITPR 1103
            :|..:|:.||   .|.:...|...|...|....|.  :|....|| .||.|..||.|  ||.|..
Zfish   881 LASAVTVTKPQTSSPASPAHNQTAPAVLQGVSSQSIIKQVAITGQLGVKTQSGAGIP--LTATNL 943

  Fly  1104 PQMPKNIIRLLPAGGAT-VTGNSVIGGTKPNSVQILGPRVVPQ---------IQTVRPAQQKIGA 1158
            ....|:::||.|:...| ..|.:|:             |:.|.         :.||:.....:.:
Zfish   944 RIQGKDVLRLPPSSITTDAKGQTVL-------------RITPDMMATLTKSPVATVKLTPDMLSS 995

  Fly  1159 VSIVANKPVTSVAAT-----ETASPVTMSTISS---PVPGGGTIVKMSPQAFANLQQQQQQLKQK 1215
            .:...:|   |::||     ...||.|.||.:|   .|....|:||:.|           :||..
Zfish   996 ATSSGSK---SISATLHVSQPQPSPPTSSTTASENLAVKTPATLVKVHP-----------ELKTA 1046

  Fly  1216 VNNA---SPALNSPQQRIIVGNTAISSNKKIVFQSLGKAAPKILTTSPSGSVTKATTNLS--PQQ 1275
            .:.|   .|||          ...::.:|...|.::..      :.|.:|:..:...||.  ||:
Zfish  1047 CDTAIRLMPAL----------AVTMADSKARTFSTVTS------SDSKAGTTIRIVPNLGVIPQK 1095

  Fly  1276 QRIVLQNFKQPVIATNQSGT--LTAVGGNATRVIRATPATSVGTGGIVGAGNPQTAGQIITLDSL 1338
            |...:.      |||..:.|  :|...|.||        .::.|.|:.|
Zfish  1096 QGQAVS------IATTTTSTKPITVSSGAAT--------VTIATSGVAG---------------- 1130

  Fly  1339 LQKQPAGGKLLTTAG-NNIFQLATSSAGNVITLSPNQTTKQLPTMTRIVSATSTTPATGNASTVV 1402
                 |.|..|.||| .:...|.|::|          |.:|:|     ||||..|..||...|
Zfish  1131 -----AKGVTLGTAGTGSTLSLGTAAA----------TVRQVP-----VSATVVTTQTGKLPT-- 1173

  Fly  1403 PKIIGKTTVLPGKPLLLHAKTLKQIGGSSVPTTQTTTTTTTAVASAAVGSG-SGAGGTVVAGT-- 1464
                 :.||    ||.:.::.||           ..:..||.:....:.:. |..|..::..|
Zfish  1174 -----RITV----PLSVLSQPLK-----------NKSVVTTPILKGNISTNISNLGRNIILTTMP 1218

  Fly  1465 -GATNAAGRTTQNIVIGGQTVKLQGAISARGAGAPVQTVIMGNQLLRLASSTSNSGTTSTSGITT 1528
             |....||....:.|...|..:||.  ..:.....:||| ...||.|.|:|:..| |.||..::|
Zfish  1219 AGTKLIAGNKPVSFVTAQQLQQLQQ--QGQATQVRIQTV-PAQQLQRTAASSPKS-TVSTVVVST 1279

  Fly  1529 AP 1530
            ||
Zfish  1280 AP 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11970	NP_001287243.1	ASXH	<129..219	CDD:290630	24/90 (27%)
CG11970	NP_001287243.1	NFRKB_winged	567..669	CDD:291154	31/109 (28%)
nfrkb	NP_001229964.1	ASXH	32..132	CDD:290630	30/106 (28%)
		NFRKB_winged	374..475	CDD:291154	31/109 (28%)
		DUF4402	1112..>1169	CDD:291050	24/100 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580883
Domainoid	1	1.000	246	1.000	Domainoid score	I2134
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2292
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006911
OrthoInspector	1	1.000	-	-		oto40865
orthoMCL	1	0.900	-	-		OOG6_106779
Panther	1	1.100	-	-	LDO	PTHR13052
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3864
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.890