DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11970 and NFRKB

DIOPT Version :9

Sequence 1:	NP_001287243.1	Gene:	CG11970 / 41072	FlyBaseID:	FBgn0027503	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	XP_016873282.1	Gene:	NFRKB / 4798	HGNCID:	7802	Length:	1341	Species:	Homo sapiens

Alignment Length:	1634	Identity:	422/1634 - (25%)
Similarity:	661/1634 - (40%)	Gaps:	399/1634 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ETEDDTSTCQSDELELAQ-------------LTGRDIFRLPRGLCENAAIFHEFFSLETWQQ-LP 138
            ||.|......:|.|||..             |.|.....||..|.|:..||.:..||.|||: |.
Human    29 ETMDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLS 93

  Fly   139 HHLQARLQPMLPDFSRLVSGQAQACAEQQRTLV-QLFNGGLQRFGQSPLLQLQRQLEEGNLRPDV 202
            ...:..||..||.|       .:..||||..|: .||:|...||| :||...|:...:|:..|:|
Human    94 DSQREHLQQFLPQF-------PEDSAEQQNELILALFSGENFRFG-NPLHIAQKLFRDGHFNPEV 150

  Fly   203 LQLRRSIQHSGRREFRFQQAERLSLLAKELFMSREQLLQHAYTSAPPSDGAFGKNLPRPRSRKRK 267
            ::.|:....|..:.:...|.:....|.|::..||..||:.|..|.|          ..|..:||.
Human   151 VKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGP----------ALPFRQKRP 205

  Fly   268 PPTLSIENKFCSQRAKKRYAQELLELIGSLEAKPGDISAEEEEEDEECRQLMDRLAKGPQEFELE 332
            .|:.:.|.:  ..|.::||    |:::..::.:.||.:...:||.....|         ::|..|
Human   206 SPSRTPEER--EWRTQQRY----LKVLREVKEECGDTALSSDEEATLDLQ---------EQFSFE 255

  Fly   333 ETKAPEPAGPGR-PSNAADKKCIYNTFFKRRPGVDDDLVLRSMQ-AEKIPKLNDKNFRKYLRDYK 395
            :..:..|:.|.| ||.|...:.:            ..|....|: |:|: :|.|.:.:..|:.:.
Human   256 DLSSWLPSSPARSPSPAVPLRVV------------PTLSTTDMKTADKV-ELGDSDLKIMLKKHH 307

  Fly   396 RRKLEQPESPEFDTSEVRLRDICTRAQFVGSFKPGRKPKALMARLNPDPPALVPIGVTPTKNEFV 460
            .::..||:.|:..|.::.|.||.||.      ..|||...         .||..:.|...|.:..
Human   308 EKRKHQPDHPDLLTGDLTLNDIMTRV------NAGRKGSL---------AALYDLAVLKKKVKEK 357

  Fly   461 DEEPMLLDEPQQLYGRRAPEDHPEEDLPHKEPPPMPKKVMPAPVVLP----QPVPKLEPLNGPIT 521
            :|:     :.:::...::..:...|.|...| ...|....|:|:.:|    :|:..|:|..|
Human   358 EEK-----KKKKIKTIKSEAEDLAEPLSSTE-GVAPLSQAPSPLAIPAIKEEPLEDLKPCLG--- 413

  Fly   522 NPKASPTTPNHSNNPITVSATAGHITGSPTREVQIRPPASPRPACFFSLLRDLFVSTPQHRLTYG 586
                        .|.|:.|                          |||||.::.:...|..|...
Human   414 ------------INEISSS--------------------------FFSLLLEILLLESQASLPML 440

  Fly   587 ELQILLSSWREINSDASIPIGEWPRFRPDWSKLLQSAINFLSGDFSSVPADYVPYIEHKTQLGIY 651
            |.::|  .|:  :|.|| .:..|....|:|::|:..|:.:|:|:..:||:.:.|::|.|.:...:
Human   441 EERVL--DWQ--SSPAS-SLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQW 500

  Fly   652 QWIGAGRDSDARLLSLCQFWLRTQRE---KQSQLSPVLISGVHLNSLVDASPTPPPRCPTTWTVR 713
            :.:|..:|::..|.:|.|.||.|:.:   ||.            |.....:.||.||..|.:.||
Human   501 KLLGQSQDNEKELAALFQLWLETKDQAFCKQE------------NEDSSDATTPVPRVRTDYVVR 553

  Fly   714 SATQAEILEFQSQERIRFEYPHRPFTYRLNGYESVVGPVKGIYTQGLPLNKARGHAVMVDDRPPF 778
            .:|..|...||.|||.|:..||:.||:|::|:|||||||||::.:...|||||.|:::..|||.:
Human   554 PSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAY 618

  Fly   779 VTILTLVRDATARLPNGEGTRSEISELLKCSQYISQQAADNVLQTIVSGALDRMHGGPDPCVKYD 843
            ||||:|||||.||||||||||:||.||||.||:::.......:.|:|||||||:|...|||||||
Human   619 VTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYD 683

  Fly   844 ARRKIWIYLHRNRSEAEFEKMHRHNQSLVKQK---QQQRKQLNRPKIPDDRSGL----AADHQQE 901
            ..||:||||||:|||.|||::|:...:..|.:   ||:.|..::.|.....|.:    :...:|.
Human   684 IGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQS 748

  Fly   902 QVPALVPAVASPVPVSVQQPVVASLQMKKPLAVKCPPVPPLKYHVPPGTPI---GGTIIS----A 959
            |: :|..:...|.||:             |:....|.:|.:....||.:.:   |.:.:|    :
Human   749 QM-SLSDSSMPPTPVT-------------PVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKS 799

  Fly   960 SSNINANQIPMQQIQKSLLKPVVVPNSAPSPVQRQLATGKSGTFAISKISPTRNTTPILVSTPSG 1024
            ||.:.....|......::|.| ....:|||..........||:..:|::.        :|:.||
Human   800 SSGVLLVSSPTMPHLGTMLSP-ASSQTAPSSQAAARVVSHSGSAGLSQVR--------VVAQPS- 854

  Fly  1025 LQTVHVATTPNQAGGSASPTVAKKLTIKKPVPNNKIGNFIIPLDQQQSGPQQQQPTQQGQHVKVQ 1089
                 :...|.|:||.|.                       .|.|..:|||.:.|.
Human   855 -----LPAVPQQSGGPAQ-----------------------TLPQMPAGPQIRVPA--------- 882

  Fly  1090 PIAGKPKALTITPRPQMPKNIIRLLPAGGATVTGNSVIGGTKPNSVQILGPRVVPQIQTVRPAQQ 1154
                     |.|....:|:.::..:|....|...          :||..||
Human   883 ---------TATQTKVVPQTVMATVPVKAQTTAA----------TVQRPGP-------------- 914

  Fly  1155 KIGAVSIVANKPVTSVAATETASPVTMSTISSP---VPGGGTIVKMSPQAFANLQQQ-----QQQ 1211
              |...:.    |||:.|  |||||:....|||   .|...|...:......|:.:|     |..
Human   915 --GQTGLT----VTSLPA--TASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLG 971

  Fly  1212 LKQKVNNASPALNSPQQRIIVGNTAISSNKKIVFQSLGKAAPKILTTSPSGSVTKATTNLSPQQQ 1276
            :|.:..|:.|              ..::|.:|..:.:.:..|..:||...|   :....::|...
Human   972 VKPQTGNSIP--------------LTATNFRIQGKDVLRLPPSSITTDAKG---QTVLRITPDMM 1019

  Fly  1277 RIVLQNFKQPVIATNQSGTLTAVGGNATRVIRATPATSVGTGGIVGAGNPQTAGQIITLDSLLQK 1341
            ..:.   |..|.....:..|...|||.|           |.|  :.|....|:..:...||
Human  1020 ATLA---KSQVTTVKLTQDLFGTGGNTT-----------GKG--ISATLHVTSNPVHAADS---- 1064

  Fly  1342 QPAGGKLLTTAGNNIFQLATSSAGNVITLSPNQTTKQLPTMTRIVSAT---STTPATGNASTVVP 1403
             ||               ..|||.     :|:.|    ||.|.:|..|   ..|.|:.:|..::|
Human  1065 -PA---------------KASSAS-----APSST----PTGTTVVKVTPDLKPTEASSSAFRLMP 1104

  Fly  1404 KI-------IGKTTVL--PGKPLLLHAKTLKQIGGSSV---PTTQTTTTTTTAVASAAVGSGSGA 1456
            .:       .||:||.  ..||    |.|::.:.|..|   ...||.|..|.|...|:|.||||.
Human  1105 ALGVSVADQKGKSTVASSEAKP----AATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGT 1165

  Fly  1457 GGTVVAGTGATNAAGRTTQNIVIGGQTVKLQ---GAISARGAGAPVQTVIMGNQLLRLASSTSNS 1518
            ..|......:.|||...|..:..|..:..:.   ||.:.|  ..||.|.::         |||.:
Human  1166 VHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVR--QVPVSTTVV---------STSQA 1219

  Fly  1519 GTTSTSGITTAPKTLLIGPRLAKNVLVA---NKQITSTANSSVVNSSTTASPAATATATPSNNLV 1580
            |...|.  .|.|.:::..|...|:|:.|   ...:.:..:....|...|..||.|.
Human  1220 GKLPTR--ITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTK--------- 1273

  Fly  1581 FAVQGNGGQLFFSPGLQGMNLKPLSSLKVIPMAAASASGAAVGGKISVTTAAG-ETGAKTLTTKL 1644
             .:.||               ||:|.|....:......|.|...:|....|:. :.|..:.::|.
Human  1274 -LIAGN---------------KPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKA 1322

  Fly  1645 IPATVLKTA 1653
            :...|:.||
Human  1323 VSTVVVTTA 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11970	NP_001287243.1	ASXH	<129..219	CDD:290630	30/91 (33%)
CG11970	NP_001287243.1	NFRKB_winged	567..669	CDD:291154	29/101 (29%)
NFRKB	XP_016873282.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147347
Domainoid	1	1.000	240	1.000	Domainoid score	I2269
eggNOG	1	0.900	-	-		E1_KOG1927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2365
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006911
OrthoInspector	1	1.000	-	-		oto90369
orthoMCL	1	0.900	-	-		OOG6_106779
Panther	1	1.100	-	-	LDO	PTHR13052
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5877
SonicParanoid	1	1.000	-	-		X3864
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870