Protein Alignment CG11970 and Nfrkb

DIOPT Version :10

• Sequence 1: NP_649851.1
• Gene: CG11970 / 41072
• FlyBaseID: FBgn0027503
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001392026.1
• Gene: Nfrkb / 235134
• MGIID: 2442410
• Length: 1308
• Species: Mus musculus
• Alignment Length: 1528
• Identity: 404/1528 - (26%)
• Similarity: 646/1528 - (42%)
• Gaps: 332/1528 - (21%)

  Fly    98 SDELELAQ-------------LTGRDIFRLPRGLCENAAIFHEFFSLETWQQ-LPHHLQARLQPM 148
            :|.|||..             |.|.....||..|.|:..||.:..||.|||: |....:..||..
Mouse     9 TDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQF 73

  Fly   149 LPDFSRLVSGQAQACAEQQRTLVQLFNGGLQRFGQSPLLQLQRQLEEGNLRPDVLQLRRSIQHSG 213
            ||.|      .|.:..:|:..::.||:|...||| :||...|:...:|:..|:|::.|:....|.
Mouse    74 LPRF------PADSVEQQRELILALFSGENFRFG-NPLHIAQKLFRDGHFNPEVVKYRQLCFKSQ 131

  Fly   214 RREFRFQQAERLSLLAKELFMSREQLLQHAYTSAPPSDGAFGKNLPRPRSRKRKPPTLSIENKFC 278
            .:.:...|.:....|.|::..||..||:.|..|.|.        ||.|  .|...|:.|.|.:
Mouse   132 YKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPA--------LPFP--HKHHSPSRSPEER-- 184

  Fly   279 SQRAKKRYAQELLELIGSLEAKPGDISAEEEEEDEECRQLMDRLAKGPQEFELEETKAPEPAGPG 343
            ..|.::||    |:::..::.:.||.:...:||.....|         ::|..|:..:..|:.|.
Mouse   185 EWRTQQRY----LKVLREVKEECGDTALSSDEEATLDLQ---------EKFSFEDLSSWLPSSPA 236

  Fly   344 R-PSNAADKKCIYNTFFKRRPGVDDDLVLRSMQ-AEKIPKLNDKNFRKYLRDYKRRKLEQPESPE 406
            | ||.|...:.:            ..|....|: |:|| :|.|.:.:..|:.:..::..||:.|:
Mouse   237 RSPSPAVPLRVV------------PTLSTTDMKTADKI-ELGDSDLKLMLKKHHEKRKHQPDHPD 288

  Fly   407 FDTSEVRLRDICTRAQFVGSFKPGRKPKALMARLNPDPPALVPIGVTPTKNEFVDEEPMLLDEPQ 471
            ..|.::.|.||.||.      ..|||...         .||..:.|...|
Mouse   289 LLTGDLTLSDIMTRV------NAGRKGSL---------AALYDLAVLKKK--------------- 323

  Fly   472 QLYGRRAPEDHPEEDLPHKEPPPMPK-KVMPAPVVLPQPVPKLEPLNGPITNPKASPTTPNHSNN 535
                           :..||.....| |::.:         :.|.|..|:::.:..||. :.:.:
Mouse   324 ---------------VKEKEEKKKKKIKLIKS---------EAEDLAEPLSSTEGVPTL-SQAPS 363

  Fly   536 PITVSATAGHITGSPTREVQIRPPASPRPACFFSLLRDLFVSTPQHRLTYGELQILLSSWREINS 600
            |:.:|:    |...|..:::.....:...:.|||||.::.:...|..|...|.::|  .|:  :|
Mouse   364 PLAISS----IKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQASLPMLEDRVL--DWQ--SS 420

  Fly   601 DASIPIGEWPRFRPDWSKLLQSAINFLSGDFSSVPADYVPYIEHKTQLGIYQWIGAGRDSDARLL 665
            .|| .:..|....|:|::|:..|:.:|:|:..:||:.:.|::|.|.:...::.:|..:|::..|.
Mouse   421 PAS-SLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELA 484

  Fly   666 SLCQFWLRTQRE---KQSQLSPVLISGVHLNSLVDASP--TPPPRCPTTWTVRSATQAEILEFQS 725
            :|...||.|:.:   |:::               |:|.  ||.||..|.:.||.:|..|...||.
Mouse   485 ALFHLWLETKDQAFCKENE---------------DSSDAMTPVPRVRTDYVVRPSTGEEKRVFQE 534

  Fly   726 QERIRFEYPHRPFTYRLNGYESVVGPVKGIYTQGLPLNKARGHAVMVDDRPPFVTILTLVRDATA 790
            |||.|:..||:.||:|::|:|||||||||::.:...|||||.|:::..|||.:||||:|||||.|
Mouse   535 QERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAA 599

  Fly   791 RLPNGEGTRSEISELLKCSQYISQQAADNVLQTIVSGALDRMHGGPDPCVKYDARRKIWIYLHRN 855
            |||||||||:||.||||.||:::.......:.|:|||||||:|...|||||||..||:||||||:
Mouse   600 RLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRD 664

  Fly   856 RSEAEFEKMHRHNQSLVKQKQQQRKQL-NRPKIPD---------DRSGLAADHQQEQVPALVPAV 910
            |||.|||::|:...:..|    .||.| .:||.|.         ...||:...:|.|: :|..:.
Mouse   665 RSEEEFERIHQAQAAAAK----ARKALQQKPKPPSKVKSSNKEGSTKGLSGPSEQSQM-SLSDSS 724

  Fly   911 ASPVPVSVQQPVVASLQMKKPLAVKCPPVPPLKYHVPPGTPIGGTIISASSNINANQIPMQQIQK 975
            ..|.||:...|...:|    |..:..|||..:..             |.||.::.   |.|....
Mouse   725 MPPTPVTPVTPTTPAL----PTPISPPPVSAVNR-------------SGSSTVSE---PAQSSSG 769

  Fly   976 SLLKPVVVPNSAPSPVQRQLATGKSGTFAISKISPTRNTTPILVSTPSGLQTVHVATTPNQAGGS 1040
            .||        ..||...||.|         .:||....||     ||...|..|.:..:.||
Mouse   770 VLL--------VSSPTMPQLGT---------MLSPASIQTP-----PSSQATARVVSHSSSAG-- 810

  Fly  1041 ASPTVAKKLTIKKP----VPNNKIGNFIIPLDQQQSGPQQQQPTQQGQHVKVQ-------PIAGK 1094
             .|.|.   .:.:|    |....:|. ..||.|..:|||.:.|....|...|.       |:.|:
Mouse   811 -LPQVR---VVAQPSLPAVSQQSVGP-AQPLPQMPAGPQIRVPVTATQTKVVPQAVMATVPVKGQ 870

  Fly  1095 PKALTI-TPRPQMPKNIIRLLPAGGATVT-------GNSVIGGTKPNSVQ-ILGPRVVPQIQTVR 1150
            ..|.:: .|.|......:..|||..:.|:       |||....:....:| :.|..::.|:...
Mouse   871 TAAASVQRPGPGQTGLTVTNLPAAVSPVSKTAMSSPGNSAPSASTTAVIQNVTGQNIIKQVSIT- 934

  Fly  1151 PAQQKIGAVSIVANKPVTSVAATETAS-------------PVTMSTISSPVPGGGTIVKMSPQAF 1202
                  |.:.:   ||.|..:...||:             |.:::|.:.    |.|:::::|...
Mouse   935 ------GQLGV---KPQTGSSIPLTATNFRIQGKDVLRLPPSSITTDAK----GQTVLRITPDMM 986

  Fly  1203 ANLQQQQQQLKQKVNNASPALNSPQQRIIVGNTAISSNKKIVFQSLGKA-APKILTTSPSG-SVT 1265
            |.|.:.|....:...:...|.:....:.|.....::||......|..|| :..:.:::|:| :|.
Mouse   987 ATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVPSSAPAGTTVV 1051

  Fly  1266 KATTNLSPQQQRIVLQNFKQPVIATNQSGTLTAVGGNATRVIRATPATSVGTG-----GIVGAGN 1325
            |.|.:|.|.:                          .|....|..||..|...     ..|.:..
Mouse  1052 KVTPDLKPTE--------------------------TANSAFRLMPALGVSVADQKGKNTVASSE 1090

  Fly  1326 PQTAGQIITLDSLLQKQPAGGKLLTTAGNNIFQLATSSAGNVITLSPNQTTKQLPTMTRIVS--- 1387
            .:.|..|..:..|....|..|:.:|.|.:  .:...|.||...|:  :.:|..||::...||
Mouse  1091 AKPAATIRIVQGLGVMPPKAGQTITVAAH--AKQGASVAGGSGTV--HSSTVSLPSINAAVSKTV 1151

  Fly  1388 -----ATSTTPATGNASTVVPKIIGKTTV--------LPGK---PLLLHAKTLKQIGGSSVPTTQ 1436
                 ||||..:.|..:..|.::...|||        ||.:   ||.:.::.:|   |.||
Mouse  1152 AVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMK---GKSV---- 1209

  Fly  1437 TTTTTTTAVASAAVGSG-SGAGGTVVAGT---GATNAAGRTTQNIVIGGQTVKLQGAISARGAGA 1497
                .|..:....:|:. ||.|..::..|   |....||....:.:...|..:||.  ..:....
Mouse  1210 ----VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQ--QGQATQV 1268

  Fly  1498 PVQTVIMGNQLLRLASSTSNSGTTSTSGITTAP 1530
            .:|||...:  |:..:::.:|...||..:||||
Mouse  1269 RIQTVPASH--LQQGTASGSSKAVSTVVVTTAP 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11970	NP_649851.1	DEUBAD_NFRKB	118..235	CDD:439381	34/117 (29%)
		NFRKB_winged	567..671	CDD:433973	29/103 (28%)
		Herpes_BLLF1	<1098..>1403	CDD:282904	67/341 (20%)
Nfrkb	NP_001392026.1	DEUBAD_NFRKB	42..153	CDD:439381	34/117 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..186		8/32 (25%)
		Winged-helix like domain. /evidence=ECO:0000250	382..507		34/144 (24%)
		NFRKB_winged	404..490	CDD:433973	24/90 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..770		26/119 (22%)
		Atrophin-1	694..>925	CDD:460830	64/280 (23%)
		PRK12688	<869..>1199	CDD:171664	77/373 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1048		4/20 (20%)