DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11970 and Nfrkb

DIOPT Version :9

Sequence 1:	NP_001287243.1	Gene:	CG11970 / 41072	FlyBaseID:	FBgn0027503	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	XP_006510281.1	Gene:	Nfrkb / 235134	MGIID:	2442410	Length:	1308	Species:	Mus musculus

Alignment Length:	1526	Identity:	405/1526 - (26%)
Similarity:	646/1526 - (42%)	Gaps:	328/1526 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SDELELAQ-------------LTGRDIFRLPRGLCENAAIFHEFFSLETWQQ-LPHHLQARLQPM 148
            :|.|||..             |.|.....||..|.|:..||.:..||.|||: |....:..||..
Mouse     9 TDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQF 73

  Fly   149 LPDFSRLVSGQAQACAEQQRTLVQLFNGGLQRFGQSPLLQLQRQLEEGNLRPDVLQLRRSIQHSG 213
            ||.|      .|.:..:|:..::.||:|...||| :||...|:...:|:..|:|::.|:....|.
Mouse    74 LPRF------PADSVEQQRELILALFSGENFRFG-NPLHIAQKLFRDGHFNPEVVKYRQLCFKSQ 131

  Fly   214 RREFRFQQAERLSLLAKELFMSREQLLQHAYTSAPPSDGAFGKNLPRPRSRKRKPPTLSIENKFC 278
            .:.:...|.:....|.|::..||..||:.|..|.|.        ||.|  .|...|:.|.|.:
Mouse   132 YKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPA--------LPFP--HKHHSPSRSPEER-- 184

  Fly   279 SQRAKKRYAQELLELIGSLEAKPGDISAEEEEEDEECRQLMDRLAKGPQEFELEETKAPEPAGPG 343
            ..|.::||    |:::..::.:.||.:...:||.....|         ::|..|:..:..|:.|.
Mouse   185 EWRTQQRY----LKVLREVKEECGDTALSSDEEATLDLQ---------EKFSFEDLSSWLPSSPA 236

  Fly   344 R-PSNAADKKCIYNTFFKRRPGVDDDLVLRSMQ-AEKIPKLNDKNFRKYLRDYKRRKLEQPESPE 406
            | ||.|...:.:            ..|....|: |:|| :|.|.:.:..|:.:..::..||:.|:
Mouse   237 RSPSPAVPLRVV------------PTLSTTDMKTADKI-ELGDSDLKLMLKKHHEKRKHQPDHPD 288

  Fly   407 FDTSEVRLRDICTRAQFVGSFKPGRKPKALMARLNPDPPALVPIGVTPTKNEFVDEEPMLLDEPQ 471
            ..|.::.|.||.||.      ..|||...         .||..:.|...|
Mouse   289 LLTGDLTLSDIMTRV------NAGRKGSL---------AALYDLAVLKKK--------------- 323

  Fly   472 QLYGRRAPEDHPEEDLPHKEPPPMPK-KVMPAPVVLPQPVPKLEPLNGPITNPKASPTTPNHSNN 535
                           :..||.....| |::.:         :.|.|..|:::.:..||. :.:.:
Mouse   324 ---------------VKEKEEKKKKKIKLIKS---------EAEDLAEPLSSTEGVPTL-SQAPS 363

  Fly   536 PITVSATAGHITGSPTREVQIRPPASPRPACFFSLLRDLFVSTPQHRLTYGELQILLSSWREINS 600
            |:.:|:    |...|..:::.....:...:.|||||.::.:...|..|...|.::|  .|:  :|
Mouse   364 PLAISS----IKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQASLPMLEDRVL--DWQ--SS 420

  Fly   601 DASIPIGEWPRFRPDWSKLLQSAINFLSGDFSSVPADYVPYIEHKTQLGIYQWIGAGRDSDARLL 665
            .|| .:..|....|:|::|:..|:.:|:|:..:||:.:.|::|.|.:...::.:|..:|::..|.
Mouse   421 PAS-SLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELA 484

  Fly   666 SLCQFWLRTQRE---KQSQLSPVLISGVHLNSLVDASPTPPPRCPTTWTVRSATQAEILEFQSQE 727
            :|...||.|:.:   |:::.|.            ||. ||.||..|.:.||.:|..|...||.||
Mouse   485 ALFHLWLETKDQAFCKENEDSS------------DAM-TPVPRVRTDYVVRPSTGEEKRVFQEQE 536

  Fly   728 RIRFEYPHRPFTYRLNGYESVVGPVKGIYTQGLPLNKARGHAVMVDDRPPFVTILTLVRDATARL 792
            |.|:..||:.||:|::|:|||||||||::.:...|||||.|:::..|||.:||||:|||||.|||
Mouse   537 RYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARL 601

  Fly   793 PNGEGTRSEISELLKCSQYISQQAADNVLQTIVSGALDRMHGGPDPCVKYDARRKIWIYLHRNRS 857
            |||||||:||.||||.||:::.......:.|:|||||||:|...|||||||..||:||||||:||
Mouse   602 PNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRS 666

  Fly   858 EAEFEKMHRHNQSLVKQKQQQRKQL-NRPKIPD---------DRSGLAADHQQEQVPALVPAVAS 912
            |.|||::|:...:..|    .||.| .:||.|.         ...||:...:|.|: :|..:...
Mouse   667 EEEFERIHQAQAAAAK----ARKALQQKPKPPSKVKSSNKEGSTKGLSGPSEQSQM-SLSDSSMP 726

  Fly   913 PVPVSVQQPVVASLQMKKPLAVKCPPVPPLKYHVPPGTPIGGTIISASSNINANQIPMQQIQKSL 977
            |.||:...|...:|    |..:..|||..:..             |.||.::.   |.|.....|
Mouse   727 PTPVTPVTPTTPAL----PTPISPPPVSAVNR-------------SGSSTVSE---PAQSSSGVL 771

  Fly   978 LKPVVVPNSAPSPVQRQLATGKSGTFAISKISPTRNTTPILVSTPSGLQTVHVATTPNQAGGSAS 1042
            |        ..||...||.|         .:||....||     ||...|..|.:..:.||   .
Mouse   772 L--------VSSPTMPQLGT---------MLSPASIQTP-----PSSQATARVVSHSSSAG---L 811

  Fly  1043 PTVAKKLTIKKP----VPNNKIGNFIIPLDQQQSGPQQQQPTQQGQHVKVQ-------PIAGKPK 1096
            |.|.   .:.:|    |....:|. ..||.|..:|||.:.|....|...|.       |:.|:..
Mouse   812 PQVR---VVAQPSLPAVSQQSVGP-AQPLPQMPAGPQIRVPVTATQTKVVPQAVMATVPVKGQTA 872

  Fly  1097 ALTI-TPRPQMPKNIIRLLPAGGATVT-------GNSVIGGTKPNSVQ-ILGPRVVPQIQTVRPA 1152
            |.:: .|.|......:..|||..:.|:       |||....:....:| :.|..::.|:...
Mouse   873 AASVQRPGPGQTGLTVTNLPAAVSPVSKTAMSSPGNSAPSASTTAVIQNVTGQNIIKQVSIT--- 934

  Fly  1153 QQKIGAVSIVANKPVTSVAATETAS-------------PVTMSTISSPVPGGGTIVKMSPQAFAN 1204
                |.:.:   ||.|..:...||:             |.:::|.:.    |.|:::::|...|.
Mouse   935 ----GQLGV---KPQTGSSIPLTATNFRIQGKDVLRLPPSSITTDAK----GQTVLRITPDMMAT 988

  Fly  1205 LQQQQQQLKQKVNNASPALNSPQQRIIVGNTAISSNKKIVFQSLGKA-APKILTTSPSG-SVTKA 1267
            |.:.|....:...:...|.:....:.|.....::||......|..|| :..:.:::|:| :|.|.
Mouse   989 LAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVPSSAPAGTTVVKV 1053

  Fly  1268 TTNLSPQQQRIVLQNFKQPVIATNQSGTLTAVGGNATRVIRATPATSVGTG-----GIVGAGNPQ 1327
            |.:|.|.:                          .|....|..||..|...     ..|.:...:
Mouse  1054 TPDLKPTE--------------------------TANSAFRLMPALGVSVADQKGKNTVASSEAK 1092

  Fly  1328 TAGQIITLDSLLQKQPAGGKLLTTAGNNIFQLATSSAGNVITLSPNQTTKQLPTMTRIVS----- 1387
            .|..|..:..|....|..|:.:|.|.:  .:...|.||...|:  :.:|..||::...||
Mouse  1093 PAATIRIVQGLGVMPPKAGQTITVAAH--AKQGASVAGGSGTV--HSSTVSLPSINAAVSKTVAV 1153

  Fly  1388 ---ATSTTPATGNASTVVPKIIGKTTV--------LPGK---PLLLHAKTLKQIGGSSVPTTQTT 1438
               ||||..:.|..:..|.::...|||        ||.:   ||.:.::.:|   |.||
Mouse  1154 ASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMK---GKSV------ 1209

  Fly  1439 TTTTTAVASAAVGSG-SGAGGTVVAGT---GATNAAGRTTQNIVIGGQTVKLQGAISARGAGAPV 1499
              .|..:....:|:. ||.|..::..|   |....||....:.:...|..:||.  ..:.....:
Mouse  1210 --VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQ--QGQATQVRI 1270

  Fly  1500 QTVIMGNQLLRLASSTSNSGTTSTSGITTAP 1530
            |||...:  |:..:::.:|...||..:||||
Mouse  1271 QTVPASH--LQQGTASGSSKAVSTVVVTTAP 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11970	NP_001287243.1	ASXH	<129..219	CDD:290630	27/90 (30%)
CG11970	NP_001287243.1	NFRKB_winged	567..669	CDD:291154	29/101 (29%)
Nfrkb	XP_006510281.1	NFRKB_winged	404..490	CDD:373080	24/90 (27%)
		PHA03247	<744..915	CDD:223021	51/215 (24%)
		PRK12688	<869..>1199	CDD:171664	77/373 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837279
Domainoid	1	1.000	252	1.000	Domainoid score	I2083
eggNOG	1	0.900	-	-		E1_KOG1927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2258
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006911
OrthoInspector	1	1.000	-	-		oto93953
orthoMCL	1	0.900	-	-		OOG6_106779
Panther	1	1.100	-	-	LDO	PTHR13052
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5877
SonicParanoid	1	1.000	-	-		X3864
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870