DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAHbeta and bca-1

DIOPT Version :9

Sequence 1:	NP_649849.1	Gene:	CAHbeta / 41070	FlyBaseID:	FBgn0037646	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_741809.1	Gene:	bca-1 / 180890	WormBaseID:	WBGene00000245	Length:	270	Species:	Caenorhabditis elegans

Alignment Length:	257	Identity:	127/257 - (49%)
Similarity:	164/257 - (63%)	Gaps:	6/257 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERILRGIMRYRNTTREQMVKEFQKVRDNPEPKAVFFTCMDSRMIPTRYTDTHVGDMFVVRNAGN 65
            |.:||||::::|||.|:.:||:|:::::||.|.||.||||||||:|||:|.:.||||||||||||
Worm     1 MNKILRGVIQFRNTIRKDLVKQFEEIKNNPSPTAVMFTCMDSRMLPTRFTQSQVGDMFVVRNAGN 65

  Fly    66 LIPHAQH---FQDEYFSCEPAALELGCVVNDIRHIIVCGHSDCKAMNLLYQLRDPDFASKLNRRL 127
            :||.|.:   |.:...:.|||||||......||||:|||||||||:|.||.|..   ..|.....
Worm    66 MIPDAPNYGAFSEVSVNTEPAALELAVKRGGIRHIVVCGHSDCKAINTLYGLHQ---CPKNFDVT 127

  Fly   128 SPLRSWLCTHANTSLERFQEWRDAGMKDPLIFSSETPLRRFVAYIDEEQKFALEDKLSQINTLQQ 192
            ||:..|:..:...|::|..|....|.......|...|.:.|.|.||.....|:||||||||.|||
Worm   128 SPMDHWVRRNGFASVKRLNERLHRGPSSMKFESEVAPSQSFDAIIDPMDTLAMEDKLSQINVLQQ 192

  Fly   193 MSNIASYGFLKARLESHDLHIHALWFDIYTGDIYYFSRGAKRFLPVDEDTVDRLSEEVRRFY 254
            :.||.|:.|||..|||..||||.:|||||.|:.|.||:..|||:.:||.||..|..|:...|
Worm   193 LINICSHEFLKEYLESGRLHIHGMWFDIYKGEDYLFSKDKKRFVVIDEKTVTDLLAELNARY 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAHbeta	NP_649849.1	beta_CA_cladeB	7..228	CDD:238449	111/223 (50%)
bca-1	NP_741809.1	beta_CA_cladeB	7..228	CDD:238449	111/223 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167093
Domainoid	1	1.000	179	1.000	Domainoid score	I2105
eggNOG	1	0.900	-	-		E1_COG0288
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25497
Inparanoid	1	1.050	240	1.000	Inparanoid score	I2104
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48332
OrthoDB	1	1.010	-	-		D1136193at2759
OrthoFinder	1	1.000	-	-		FOG0003269
OrthoInspector	1	1.000	-	-		otm14498
orthoMCL	1	0.900	-	-		OOG6_100995
Panther	1	1.100	-	-	LDO	PTHR11002
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16263
SonicParanoid	1	1.000	-	-		X7634
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800