DRSC/TRiP Functional Genomics Resources

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Protein Alignment ich and ZNF212

DIOPT Version :9

Sequence 1:NP_001262393.1 Gene:ich / 41069 FlyBaseID:FBgn0286204 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_036388.2 Gene:ZNF212 / 7988 HGNCID:13004 Length:495 Species:Homo sapiens


Alignment Length:392 Identity:91/392 - (23%)
Similarity:135/392 - (34%) Gaps:123/392 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 VPNQLDKDDNNDTRDSWMDLDAWIDGNCIQQESAKVLVSQQDSLGDFILPHSPLPMHASSSTLQS 333
            |...|:.|....|...|.:|:.|      |:|..:.:                  |.::..||.|
Human   139 VSRSLENDGVCFTEQEWENLEDW------QKELYRNV------------------MESNYETLVS 179

  Fly   334 LLSHGY--------MPLLQNRLQNGPPNGNSSGGGGGANQGAGI----------KGDPQAPTSTS 380
            |...|.        ..:|.:..:.||         |||:...|:          :|....|...|
Human   180 LKVLGQTEGEAELGTEMLGDLEEEGP---------GGAHPAGGVMIKQELQYTQEGPADLPGEFS 235

  Fly   381 YC------------NELAAATSSSC---SPPGSVVSTTDNPNGLMINPRYLSNPTNNQATGNLHQ 430
             |            .||.....||.   :.||.  ||.:.|.|..:       |::::..|...|
Human   236 -CIAEEQAFLSPEQTELWGGQGSSVLLETGPGD--STLEEPVGSRV-------PSSSRTVGCPKQ 290

  Fly   431 QGGYSMQ-----ASGLSLKDNGL----CSP-DLLGNY---------PHTTTASTTGSEMRTGAPK 476
            :....:|     ..||.||.:..    ||. ::...|         .|:...|.|..|.......
Human   291 KSHRQVQLDQECGQGLKLKKDTSRPYECSECEITFRYKQQLATHLRSHSGWGSCTPEEPEESLRP 355

  Fly   477 AKRSRSQKKSNQQQQ---------------QQQQQQQQQGDGGGQPTTPQMSAISPSGFSASDLS 526
            ..|.:.|.|..:..|               ..|:...|:|...||....:        ||.:.|.
Human   356 RPRLKPQTKKAKLHQCDVCLRSFSCKVSLVTHQRCHLQEGPSAGQHVQER--------FSPNSLV 412

  Fly   527 GLLG-----KEKPVHRCSICNRGFLNKSNIKVHLRTHTGEKPFRCDVCAKAFRQKAHLLKHQQIH 586
            .|.|     |.:....|..|.:.|.:.|::..|.|.||||:|:.|..|.|:|.||.|||:||:||
Human   413 ALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHTGERPYSCTECEKSFVQKQHLLQHQKIH 477

  Fly   587 KR 588
            :|
Human   478 QR 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ichNP_001262393.1 C2H2 Zn finger 538..558 CDD:275368 6/19 (32%)
zf-H2C2_2 550..575 CDD:316026 11/24 (46%)
C2H2 Zn finger 566..586 CDD:275368 11/19 (58%)
ZNF212NP_036388.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
KRAB_A-box 142..180 CDD:143639 11/61 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..290 8/34 (24%)
C2H2 Zn finger 318..338 CDD:275370 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..361 5/23 (22%)
COG5048 <367..479 CDD:227381 36/119 (30%)
C2H2 Zn finger 371..391 CDD:275368 1/19 (5%)
C2H2 Zn finger 429..449 CDD:275368 6/19 (32%)
zf-C2H2 429..449 CDD:306579 6/19 (32%)
zf-H2C2_2 441..466 CDD:316026 11/24 (46%)
C2H2 Zn finger 457..477 CDD:275368 11/19 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..495 3/4 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5275
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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