DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ich and ham

DIOPT Version :9

Sequence 1:NP_001262393.1 Gene:ich / 41069 FlyBaseID:FBgn0286204 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster


Alignment Length:597 Identity:123/597 - (20%)
Similarity:188/597 - (31%) Gaps:181/597 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SSLNALSDLKPLPPFTGYTGHLSINGISGHHYHAIAQRLPDESNNNYMQSAYHPQNQSNPTSTTQ 135
            |:|.:|:..|.....|| .|......::.||.|.....||           :.|...:..|||..
  Fly   494 STLTSLTKHKKFCDSTG-PGPYRNQHVNRHHQHPHQHPLP-----------HQPHLAATATSTCP 546

  Fly   136 SNGGSNSNSNNSNEHNIVSSSTCLPESVLS-------GSGGGGGGNDACLADVKL--------FA 185
            :....:|.|::|.....|::.:..|...|.       ..|....|....|....|        |:
  Fly   547 APPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFS 611

  Fly   186 DSQLDSKLYSVADSCVMNGSGSGSAANGNGSGPSIATLTPIDQVADSL-------HNSGVRIYKD 243
            .:.:|              .|.|        ||.|.  :|:......|       .||..:.|..
  Fly   612 KNPMD--------------LGCG--------GPEIT--SPVSAFDQKLPFGFLKGENSESQAYDK 652

  Fly   244 LTEYVDMNSIDD-------IAAIIGSAIADTTVPNQLD-----KDDNNDTRDSWMDLDAWIDGNC 296
            :||...:...::       :.|..|.   :....:.||     :|..||::....|        .
  Fly   653 VTEKELVFKAEEKLKKEPLVQAFEGE---EDESRSSLDIKGKLEDTRNDSKSEEQD--------D 706

  Fly   297 IQQESAKVLVSQQDSLGD----FILPHSPLPMHASSS----------------------TLQSLL 335
            ::||..:|....|....|    ..:..:|.|....|.                      ...:|:
  Fly   707 MKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLM 771

  Fly   336 SHGYMPLLQN-RLQNGPP----NGNSSGGGGGANQGAGIKGDPQAPTSTSYCNELAAATSSSCSP 395
            .|.:||.|.. ..:.|.|    ..:||.....:.:..  ||....||.|:     :...:.|.||
  Fly   772 LHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSH--KGSSPTPTPTA-----SPGLTPSPSP 829

  Fly   396 P---GSVVSTTDNPNGLMI---------NPRYLSNPTNNQATGNLHQQGGYSMQASGLSLKDNGL 448
            |   |..:|:|.....:..         :....|.||..|.....|......:..||...    |
  Fly   830 PTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPF----L 890

  Fly   449 CSPDLLGNYPHTTTASTTGSE-MRTGAPKAKRSRSQKKSNQQQQQQQQQQQQQGDGGGQPTTPQM 512
            |.|           ....|.| :..||..|                           ..|..|  
  Fly   891 CQP-----------GGRRGIEALLAGAASA---------------------------AAPKRP-- 915

  Fly   513 SAISPSGFSASDLSGLLGKEKPVHRCSICNRGFLNKSNIKVHLRTHTGEKPFRCDVCAKAFRQKA 577
              :.|..|||..:.||  |.|..:.|..|.:.|...:|:..||||||||:|:.|..|.:||...:
  Fly   916 --LPPVKFSAGSVVGL--KTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISS 976

  Fly   578 HLLKH-QQIHKR 588
            :|.:| :.||.:
  Fly   977 NLQRHVRNIHNK 988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ichNP_001262393.1 C2H2 Zn finger 538..558 CDD:275368 7/19 (37%)
zf-H2C2_2 550..575 CDD:316026 14/24 (58%)
C2H2 Zn finger 566..586 CDD:275368 6/20 (30%)
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368
C2H2 Zn finger 371..392 CDD:275368
SFP1 <391..479 CDD:227516
C2H2 Zn finger 400..421 CDD:275368
SUF4-like 403..>445 CDD:411020
C2H2 Zn finger 403..421 CDD:411020
C2H2 Zn finger 429..449 CDD:275368
C2H2 Zn finger 457..477 CDD:275368
C2H2 Zn finger 486..504 CDD:275368 3/9 (33%)
PTZ00121 <641..>728 CDD:173412 18/97 (19%)
COG5048 935..>1028 CDD:227381 21/54 (39%)
zf-C2H2 935..957 CDD:395048 7/21 (33%)
C2H2 Zn finger 937..957 CDD:275368 7/19 (37%)
zf-H2C2_2 949..973 CDD:404364 13/23 (57%)
C2H2 Zn finger 965..986 CDD:275368 6/20 (30%)
C2H2 Zn finger 994..1014 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24393
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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